Towards the development of a 3D cell model to study interactions between glioma cells and microglia

Detalhes bibliográficos
Autor(a) principal: de Castro Sobral, Francisco
Data de Publicação: 2023
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/163315
Resumo: "Gliomas are central nervous system tumors with glial origin. A subset of aggressive, highgrade gliomas, which includes glioblastoma (GBM) and several pediatric gliomas, is characterized by immunosuppressive tumor microenvironments (TMEs). These immunosuppressive TMEs were recently associated with increased tumorigenicity and reduced effectiveness of immunotherapies. The molecular crosstalk between cancer and non-cancer cells (e.g., microglia, astrocytes) establishes and sustains the immunosuppressive TME. However, the molecular mechanisms underlying immunosuppression in different glioma subtypes are not well described, mainly due to the lack of adequate experimental models to address them. Most glioma cell models fail to include the different cell types of the TME. (...)"
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spelling Towards the development of a 3D cell model to study interactions between glioma cells and microgliagliomasmicrogliatumor microenvironmentimmunosuppression"Gliomas are central nervous system tumors with glial origin. A subset of aggressive, highgrade gliomas, which includes glioblastoma (GBM) and several pediatric gliomas, is characterized by immunosuppressive tumor microenvironments (TMEs). These immunosuppressive TMEs were recently associated with increased tumorigenicity and reduced effectiveness of immunotherapies. The molecular crosstalk between cancer and non-cancer cells (e.g., microglia, astrocytes) establishes and sustains the immunosuppressive TME. However, the molecular mechanisms underlying immunosuppression in different glioma subtypes are not well described, mainly due to the lack of adequate experimental models to address them. Most glioma cell models fail to include the different cell types of the TME. (...)"Instituto de Tecnologia Química e Biológica António Xavier. Universidade NOVA de Lisboa.RUNde Castro Sobral, Francisco2024-02-09T08:20:53Z2023-05-302023-05-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/163315TID:203518888enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:46:29Zoai:run.unl.pt:10362/163315Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:21.640097Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Towards the development of a 3D cell model to study interactions between glioma cells and microglia
title Towards the development of a 3D cell model to study interactions between glioma cells and microglia
spellingShingle Towards the development of a 3D cell model to study interactions between glioma cells and microglia
de Castro Sobral, Francisco
gliomas
microglia
tumor microenvironment
immunosuppression
title_short Towards the development of a 3D cell model to study interactions between glioma cells and microglia
title_full Towards the development of a 3D cell model to study interactions between glioma cells and microglia
title_fullStr Towards the development of a 3D cell model to study interactions between glioma cells and microglia
title_full_unstemmed Towards the development of a 3D cell model to study interactions between glioma cells and microglia
title_sort Towards the development of a 3D cell model to study interactions between glioma cells and microglia
author de Castro Sobral, Francisco
author_facet de Castro Sobral, Francisco
author_role author
dc.contributor.none.fl_str_mv RUN
dc.contributor.author.fl_str_mv de Castro Sobral, Francisco
dc.subject.por.fl_str_mv gliomas
microglia
tumor microenvironment
immunosuppression
topic gliomas
microglia
tumor microenvironment
immunosuppression
description "Gliomas are central nervous system tumors with glial origin. A subset of aggressive, highgrade gliomas, which includes glioblastoma (GBM) and several pediatric gliomas, is characterized by immunosuppressive tumor microenvironments (TMEs). These immunosuppressive TMEs were recently associated with increased tumorigenicity and reduced effectiveness of immunotherapies. The molecular crosstalk between cancer and non-cancer cells (e.g., microglia, astrocytes) establishes and sustains the immunosuppressive TME. However, the molecular mechanisms underlying immunosuppression in different glioma subtypes are not well described, mainly due to the lack of adequate experimental models to address them. Most glioma cell models fail to include the different cell types of the TME. (...)"
publishDate 2023
dc.date.none.fl_str_mv 2023-05-30
2023-05-30T00:00:00Z
2024-02-09T08:20:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/163315
TID:203518888
url http://hdl.handle.net/10362/163315
identifier_str_mv TID:203518888
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier. Universidade NOVA de Lisboa.
publisher.none.fl_str_mv Instituto de Tecnologia Química e Biológica António Xavier. Universidade NOVA de Lisboa.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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