Gold-based nanoplataform for the treatment of anaplastic thyroid carcinoma

Detalhes bibliográficos
Autor(a) principal: Amaral, Mariana
Data de Publicação: 2021
Outros Autores: Charmier, Adília J., Afonso, Ricardo A., Catarino, José, Faísca, Pedro, Carvalho, Lina, Ascensão, Lia, Coelho, João M.P., Manuela Gaspar, M., Reis, Catarina Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/114452
Resumo: Funding: Authors gratefully acknowledge Fundação para a Ciência e a Tecnologia (FCT) through projects UIDB/00645/2020, UIDB/04138/2020, PTDC/MED-QUI/31721/2017, UIDP/04138/2020 and Lusófona University, ULHT. Authors are also thankful to FCT/MCTES for the financial support to CESAM (UIDP/50017/2020, UIDB/50017/2020), through national funds.
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spelling Gold-based nanoplataform for the treatment of anaplastic thyroid carcinomaA step forwardAnaplastic thyroid carcinomaGold nanoparticlesNovel therapiesPhotothermal therapyOncologyCancer ResearchSDG 3 - Good Health and Well-beingFunding: Authors gratefully acknowledge Fundação para a Ciência e a Tecnologia (FCT) through projects UIDB/00645/2020, UIDB/04138/2020, PTDC/MED-QUI/31721/2017, UIDP/04138/2020 and Lusófona University, ULHT. Authors are also thankful to FCT/MCTES for the financial support to CESAM (UIDP/50017/2020, UIDB/50017/2020), through national funds.Anaplastic thyroid carcinoma (ATC) is a very rare subtype of thyroid carcinoma and one of the most lethal malignancies. Poor prognosis is mainly associated with its undifferentiated nature, inoperability, and failing to respond to the typically used therapies for thyroid cancer. Photothermal Therapy (PTT) entails using light to increase tissues’ temperature, leading to hyperthermia-mediated cell death. Tumours are more susceptible to heat as they are unable to dissipate it. By using functionalized gold nanoparticles (AuNPs) that transform light energy into heat, it is possible to target the heat to the tumour. This study aims to formulate ATC-targeted AuNPs able to convert near-infrared light into heat, for PTT of ATC. Different AuNPs were synthetized and coated. Size, morphology, and surface plasmon resonances band were determined. The optimized coated-AuNPs were then functionalized with ligands to assess ATC’s specificity. Safety, efficacy, and selectivity were assessed in vitro. The formulations were deemed safe when not irradiated (>70% cell viability) and selective for ATC. However, when irradiated, holo-transferrin-AuNPs were the most cytotoxic (22% of cell viability). The biodistribution and safety of this formulation was assessed in vivo. Overall, this novel formulation appears to be a highly promising approach to evaluate in a very near future.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)DF – Departamento de FísicaFaculdade de Ciências e Tecnologia (FCT)RUNAmaral, MarianaCharmier, Adília J.Afonso, Ricardo A.Catarino, JoséFaísca, PedroCarvalho, LinaAscensão, LiaCoelho, João M.P.Manuela Gaspar, M.Reis, Catarina Pinto2021-03-25T23:30:07Z2021-03-022021-03-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article24application/pdfhttp://hdl.handle.net/10362/114452eng2072-6694PURE: 28725583https://doi.org/10.3390/cancers13061242info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:57:07Zoai:run.unl.pt:10362/114452Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:31.842688Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Gold-based nanoplataform for the treatment of anaplastic thyroid carcinoma
A step forward
title Gold-based nanoplataform for the treatment of anaplastic thyroid carcinoma
spellingShingle Gold-based nanoplataform for the treatment of anaplastic thyroid carcinoma
Amaral, Mariana
Anaplastic thyroid carcinoma
Gold nanoparticles
Novel therapies
Photothermal therapy
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
title_short Gold-based nanoplataform for the treatment of anaplastic thyroid carcinoma
title_full Gold-based nanoplataform for the treatment of anaplastic thyroid carcinoma
title_fullStr Gold-based nanoplataform for the treatment of anaplastic thyroid carcinoma
title_full_unstemmed Gold-based nanoplataform for the treatment of anaplastic thyroid carcinoma
title_sort Gold-based nanoplataform for the treatment of anaplastic thyroid carcinoma
author Amaral, Mariana
author_facet Amaral, Mariana
Charmier, Adília J.
Afonso, Ricardo A.
Catarino, José
Faísca, Pedro
Carvalho, Lina
Ascensão, Lia
Coelho, João M.P.
Manuela Gaspar, M.
Reis, Catarina Pinto
author_role author
author2 Charmier, Adília J.
Afonso, Ricardo A.
Catarino, José
Faísca, Pedro
Carvalho, Lina
Ascensão, Lia
Coelho, João M.P.
Manuela Gaspar, M.
Reis, Catarina Pinto
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
DF – Departamento de Física
Faculdade de Ciências e Tecnologia (FCT)
RUN
dc.contributor.author.fl_str_mv Amaral, Mariana
Charmier, Adília J.
Afonso, Ricardo A.
Catarino, José
Faísca, Pedro
Carvalho, Lina
Ascensão, Lia
Coelho, João M.P.
Manuela Gaspar, M.
Reis, Catarina Pinto
dc.subject.por.fl_str_mv Anaplastic thyroid carcinoma
Gold nanoparticles
Novel therapies
Photothermal therapy
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
topic Anaplastic thyroid carcinoma
Gold nanoparticles
Novel therapies
Photothermal therapy
Oncology
Cancer Research
SDG 3 - Good Health and Well-being
description Funding: Authors gratefully acknowledge Fundação para a Ciência e a Tecnologia (FCT) through projects UIDB/00645/2020, UIDB/04138/2020, PTDC/MED-QUI/31721/2017, UIDP/04138/2020 and Lusófona University, ULHT. Authors are also thankful to FCT/MCTES for the financial support to CESAM (UIDP/50017/2020, UIDB/50017/2020), through national funds.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-25T23:30:07Z
2021-03-02
2021-03-02T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/114452
url http://hdl.handle.net/10362/114452
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2072-6694
PURE: 28725583
https://doi.org/10.3390/cancers13061242
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 24
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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