Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts

Detalhes bibliográficos
Autor(a) principal: Grundmann, H.
Data de Publicação: 2010
Outros Autores: Livermore, D. M., Giske, C. G., Canton, R., Rossolini, G. M., Campos, J., Vatopoulos, A., Gniadkowski, M., Toth, A., Pfeifer, Y., Jarlier, V., Carmeli, Y., The CNSE Working Group
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/206
Resumo: The CNSE Working Group: Manuela Caniça (Departamento de Doenças Infecciosas do INSA)
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spelling Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national expertsEnterobacteriaceaeCarbapenemResistência aos AntimicrobianosThe CNSE Working Group: Manuela Caniça (Departamento de Doenças Infecciosas do INSA)Erratum in Euro Surveill. 2011;16(5). pii: 19781. Euro Surveill. 2011;16(3). pii: 19766. Garcia Fernandez, Aurora [corrected to Garcia-Fernandez, Aurora]; Leverstein, Maurine [corrected to Leverstein-van Hall, Maurine A]. Euro Surveill. 2010 Nov 25;15(47)pii: 19726. Euro Surveill. 2010;15(50). pii: 19755.Comment in Euro Surveill. 2010;15(50). pii: 19752The emergence and global spread of carbapenemase-producing Enterobacteriaceae is of great concern to health services worldwide. These bacteria are often resistant to all beta-lactam antibiotics and frequently co-resistant to most other antibiotics, leaving very few treatment options. The epidemiology is compounded by the diversity of carbapenem-hydrolysing enzymes and the ability of their genes to spread between different bacterial species. Difficulties are also encountered by laboratories when trying to detect carbapenemase production during routine diagnostic procedures due to an often heterogeneous expression of resistance. Some of the resistance genes are associated with successful clonal lineages which have a selective advantage in those hospitals where antimicrobial use is high and opportunities for transmission exist; others are more often associated with transmissible plasmids. A genetically distinct strain of Klebsiella pneumoniae sequence type (ST) 258 harbouring the K. pneumoniae carbapenemases (KPC) has been causing epidemics of national and international proportions. It follows the pathways of patient referrals, causing hospital outbreaks along the way. Simultaneously, diverse strains harbouring New Delhi metallo-beta-lactamase (NDM-1) are repeatedly being imported into Europe, commonly via patients with prior medical exposure in the Indian subcontinent. Since the nature and scale of carbapenem-non-susceptible Entrobacteriaceae as a threat to hospital patients in Europe remains unclear, a consultation of experts from 31 countries set out to identify the gaps in diagnostic and response capacity, to index the magnitude of carbapenem-non-susceptibility across Europe using a novel five-level staging system, and to provide elements of a strategy to combat this public health issue in a concerted manner.European Centre for Disease Prevention and ControlRepositório Científico do Instituto Nacional de SaúdeGrundmann, H.Livermore, D. M.Giske, C. G.Canton, R.Rossolini, G. M.Campos, J.Vatopoulos, A.Gniadkowski, M.Toth, A.Pfeifer, Y.Jarlier, V.Carmeli, Y.The CNSE Working Group2011-09-19T12:37:15Z2010-11-182010-11-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/206engEuro Surveill. 2010 Nov 18;15(46). pii: 197111025-496Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:38:04Zoai:repositorio.insa.pt:10400.18/206Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:35:25.414028Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts
title Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts
spellingShingle Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts
Grundmann, H.
Enterobacteriaceae
Carbapenem
Resistência aos Antimicrobianos
title_short Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts
title_full Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts
title_fullStr Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts
title_full_unstemmed Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts
title_sort Carbapenem-non-susceptible Enterobacteriaceae in Europe: conclusions from a meeting of national experts
author Grundmann, H.
author_facet Grundmann, H.
Livermore, D. M.
Giske, C. G.
Canton, R.
Rossolini, G. M.
Campos, J.
Vatopoulos, A.
Gniadkowski, M.
Toth, A.
Pfeifer, Y.
Jarlier, V.
Carmeli, Y.
The CNSE Working Group
author_role author
author2 Livermore, D. M.
Giske, C. G.
Canton, R.
Rossolini, G. M.
Campos, J.
Vatopoulos, A.
Gniadkowski, M.
Toth, A.
Pfeifer, Y.
Jarlier, V.
Carmeli, Y.
The CNSE Working Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Grundmann, H.
Livermore, D. M.
Giske, C. G.
Canton, R.
Rossolini, G. M.
Campos, J.
Vatopoulos, A.
Gniadkowski, M.
Toth, A.
Pfeifer, Y.
Jarlier, V.
Carmeli, Y.
The CNSE Working Group
dc.subject.por.fl_str_mv Enterobacteriaceae
Carbapenem
Resistência aos Antimicrobianos
topic Enterobacteriaceae
Carbapenem
Resistência aos Antimicrobianos
description The CNSE Working Group: Manuela Caniça (Departamento de Doenças Infecciosas do INSA)
publishDate 2010
dc.date.none.fl_str_mv 2010-11-18
2010-11-18T00:00:00Z
2011-09-19T12:37:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/206
url http://hdl.handle.net/10400.18/206
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Euro Surveill. 2010 Nov 18;15(46). pii: 19711
1025-496X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv European Centre for Disease Prevention and Control
publisher.none.fl_str_mv European Centre for Disease Prevention and Control
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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