Sustainable silk-based particulate systems for the controlled release of pharmaceuticals and bioactive agents in wound healing and skin regeneration

Detalhes bibliográficos
Autor(a) principal: Bernardes, Beatriz G.
Data de Publicação: 2024
Outros Autores: Veiga, Anabela, Barros, Joana, García-González, Carlos A., Oliveira, Ana Leite
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/44192
Resumo: The increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems in promoting the controlled release of pharmaceuticals and bioactive agents in the context of wound healing and skin regeneration. Silk fibroin and sericin are derived from well-established silkworm production and constitute a unique biocompatible and biodegradable protein platform for the development of drug delivery systems. The controlled release of therapeutic compounds from silk-based particulate systems not only ensures optimal bioavailability but also addresses the challenges associated with conventional delivery methods. The multifaceted benefits of silk proteins, including their inherent biocompatibility, versatility, and sustainability, are explored in this review. Furthermore, the intricate mechanisms by which controlled drug release takes place from silk-based carriers are discussed.
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spelling Sustainable silk-based particulate systems for the controlled release of pharmaceuticals and bioactive agents in wound healing and skin regenerationSilk proteinsDrug carriersParticulate systemsWound healingTissue engineeringThe increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems in promoting the controlled release of pharmaceuticals and bioactive agents in the context of wound healing and skin regeneration. Silk fibroin and sericin are derived from well-established silkworm production and constitute a unique biocompatible and biodegradable protein platform for the development of drug delivery systems. The controlled release of therapeutic compounds from silk-based particulate systems not only ensures optimal bioavailability but also addresses the challenges associated with conventional delivery methods. The multifaceted benefits of silk proteins, including their inherent biocompatibility, versatility, and sustainability, are explored in this review. Furthermore, the intricate mechanisms by which controlled drug release takes place from silk-based carriers are discussed.Veritati - Repositório Institucional da Universidade Católica PortuguesaBernardes, Beatriz G.Veiga, AnabelaBarros, JoanaGarcía-González, Carlos A.Oliveira, Ana Leite2024-03-08T16:43:17Z2024-03-082024-03-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/44192eng1422-006710.3390/ijms25063133info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-12T01:39:50Zoai:repositorio.ucp.pt:10400.14/44192Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:24.146087Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sustainable silk-based particulate systems for the controlled release of pharmaceuticals and bioactive agents in wound healing and skin regeneration
title Sustainable silk-based particulate systems for the controlled release of pharmaceuticals and bioactive agents in wound healing and skin regeneration
spellingShingle Sustainable silk-based particulate systems for the controlled release of pharmaceuticals and bioactive agents in wound healing and skin regeneration
Bernardes, Beatriz G.
Silk proteins
Drug carriers
Particulate systems
Wound healing
Tissue engineering
title_short Sustainable silk-based particulate systems for the controlled release of pharmaceuticals and bioactive agents in wound healing and skin regeneration
title_full Sustainable silk-based particulate systems for the controlled release of pharmaceuticals and bioactive agents in wound healing and skin regeneration
title_fullStr Sustainable silk-based particulate systems for the controlled release of pharmaceuticals and bioactive agents in wound healing and skin regeneration
title_full_unstemmed Sustainable silk-based particulate systems for the controlled release of pharmaceuticals and bioactive agents in wound healing and skin regeneration
title_sort Sustainable silk-based particulate systems for the controlled release of pharmaceuticals and bioactive agents in wound healing and skin regeneration
author Bernardes, Beatriz G.
author_facet Bernardes, Beatriz G.
Veiga, Anabela
Barros, Joana
García-González, Carlos A.
Oliveira, Ana Leite
author_role author
author2 Veiga, Anabela
Barros, Joana
García-González, Carlos A.
Oliveira, Ana Leite
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Bernardes, Beatriz G.
Veiga, Anabela
Barros, Joana
García-González, Carlos A.
Oliveira, Ana Leite
dc.subject.por.fl_str_mv Silk proteins
Drug carriers
Particulate systems
Wound healing
Tissue engineering
topic Silk proteins
Drug carriers
Particulate systems
Wound healing
Tissue engineering
description The increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems in promoting the controlled release of pharmaceuticals and bioactive agents in the context of wound healing and skin regeneration. Silk fibroin and sericin are derived from well-established silkworm production and constitute a unique biocompatible and biodegradable protein platform for the development of drug delivery systems. The controlled release of therapeutic compounds from silk-based particulate systems not only ensures optimal bioavailability but also addresses the challenges associated with conventional delivery methods. The multifaceted benefits of silk proteins, including their inherent biocompatibility, versatility, and sustainability, are explored in this review. Furthermore, the intricate mechanisms by which controlled drug release takes place from silk-based carriers are discussed.
publishDate 2024
dc.date.none.fl_str_mv 2024-03-08T16:43:17Z
2024-03-08
2024-03-08T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.14/44192
url http://hdl.handle.net/10400.14/44192
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-0067
10.3390/ijms25063133
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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