Three New Labdanes Isolated from Eragrostis viscosa

Detalhes bibliográficos
Autor(a) principal: Gaspar, Jorge F.
Data de Publicação: 2012
Outros Autores: Martins, Célia, Rueff, José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/23558
Resumo: This work was partially funded by the projects POCTI/QUI/39380/2001 and FCOMP-01-0124-FEDER-007430 (under COMPETE with FEDER funding) of the Fundacao para a Ciencia e Tecnologia (FCT) and the Textile and Paper Materials Center. One of the authors (N'S. N. Sebastiao) gratefully acknowledges a GRICES PhD scholarship and INABE (Angola) for financial support.
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spelling Three New Labdanes Isolated from Eragrostis viscosagenotoxicityEragrostis viscosamutagenic activityHUMAN-LYMPHOCYTESNUTRITIVE-VALUEcytotoxic activityCURVULA8 alpha,15-epoxylabdanesMICRONUCLEUS ASSAYANTIOXIDANTThis work was partially funded by the projects POCTI/QUI/39380/2001 and FCOMP-01-0124-FEDER-007430 (under COMPETE with FEDER funding) of the Fundacao para a Ciencia e Tecnologia (FCT) and the Textile and Paper Materials Center. One of the authors (N'S. N. Sebastiao) gratefully acknowledges a GRICES PhD scholarship and INABE (Angola) for financial support.Three new labdanes with 8 alpha,15-epoxy ring {[}methyl 8 alpha,15-epoxylabdan-16 beta-oate, 8 alpha,15-epoxylabdan-16 beta-ol and 8 alpha,15-epoxy-16-norlabdan-13 beta-ol] and five known compounds {[}8 alpha,15-epoxy-16-norlabdan-13-one, 8 alpha,15-epoxylabdan-16 beta-oic acid, 3 beta-(3 `',4 `'-dihydroxy)-(E)-cinnamoyloxylup-20(29)-ene, 3-(2',3' 4',6'-tetra-O-acetyl-beta-D-glucopyranosyloxy)-beta-sitosterol and 16-acetoxy-8 alpha,15-epoxylabdane] were isolated from toluene and dichloromethane extracts of aerial parts of Eragrostis viscosa. The structures of all the compounds were established based on their spectroscopic data and X-ray diffraction analysis of 8 alpha,15-epoxylabdan-16 beta-ol. It was also studied the genotoxicity of E. viscosa, particularly compounds 16-acetoxy-8 alpha,15-epoxylabdane, 8 alpha,15-epoxy-16-norlabdan-13-one and 8 alpha,15-epoxilabdan-16 beta-ol, using a cytokinesis-block micronucleus assay and the Ames test to assess mutagenicity. Both assays were negative. Cytotoxicity was also analyzed using an MTT assay, and 8 alpha,15-epoxy-16 beta-ol was shown to be the most cytotoxic of the compounds tested. E. viscosa extracts were also tested to determine their antioxidant capacities, peroxide values and total phenolic contents.}}NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNGaspar, Jorge F.Martins, CéliaRueff, José2017-09-25T22:00:36Z2012-102012-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/23558eng0103-5053PURE: 182497https://doi.org/10.1590/S0103-50532012005000067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:11:49Zoai:run.unl.pt:10362/23558Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:27:50.123905Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Three New Labdanes Isolated from Eragrostis viscosa
title Three New Labdanes Isolated from Eragrostis viscosa
spellingShingle Three New Labdanes Isolated from Eragrostis viscosa
Gaspar, Jorge F.
genotoxicity
Eragrostis viscosa
mutagenic activity
HUMAN-LYMPHOCYTES
NUTRITIVE-VALUE
cytotoxic activity
CURVULA
8 alpha,15-epoxylabdanes
MICRONUCLEUS ASSAY
ANTIOXIDANT
title_short Three New Labdanes Isolated from Eragrostis viscosa
title_full Three New Labdanes Isolated from Eragrostis viscosa
title_fullStr Three New Labdanes Isolated from Eragrostis viscosa
title_full_unstemmed Three New Labdanes Isolated from Eragrostis viscosa
title_sort Three New Labdanes Isolated from Eragrostis viscosa
author Gaspar, Jorge F.
author_facet Gaspar, Jorge F.
Martins, Célia
Rueff, José
author_role author
author2 Martins, Célia
Rueff, José
author2_role author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Gaspar, Jorge F.
Martins, Célia
Rueff, José
dc.subject.por.fl_str_mv genotoxicity
Eragrostis viscosa
mutagenic activity
HUMAN-LYMPHOCYTES
NUTRITIVE-VALUE
cytotoxic activity
CURVULA
8 alpha,15-epoxylabdanes
MICRONUCLEUS ASSAY
ANTIOXIDANT
topic genotoxicity
Eragrostis viscosa
mutagenic activity
HUMAN-LYMPHOCYTES
NUTRITIVE-VALUE
cytotoxic activity
CURVULA
8 alpha,15-epoxylabdanes
MICRONUCLEUS ASSAY
ANTIOXIDANT
description This work was partially funded by the projects POCTI/QUI/39380/2001 and FCOMP-01-0124-FEDER-007430 (under COMPETE with FEDER funding) of the Fundacao para a Ciencia e Tecnologia (FCT) and the Textile and Paper Materials Center. One of the authors (N'S. N. Sebastiao) gratefully acknowledges a GRICES PhD scholarship and INABE (Angola) for financial support.
publishDate 2012
dc.date.none.fl_str_mv 2012-10
2012-10-01T00:00:00Z
2017-09-25T22:00:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/23558
url http://hdl.handle.net/10362/23558
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0103-5053
PURE: 182497
https://doi.org/10.1590/S0103-50532012005000067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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