Serum Fetuin-A Levels Are Associated with Serum Triglycerides Before and 6 Months after Bariatric Surgery
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/2929 |
Resumo: | OBJECTIVE: The elucidation of the changes of fetuin-A in the context of bariatric surgery. DESIGN: Twenty obese patients (8 males, 12 females; body mass index = 42.5±3.4 kg/m2) were studied at baseline and 6 months after bariatric surgery. RESULTS: Serum fetuin-A levels did not differ with regard to the presence of each individual component of the Metabolic Syndrome (MetS) at baseline, except for hypertriglyceridaemia [increased serum fetuin-A levels (p=0.011)]. Circulating fetuin-A was positively correlated with serum triglycerides (TG) (r=0.461, p=0.047) and negatively correlated with serum globulins (r=-0.477, p=0.033) and C-reactive protein (CRP) (r=-0.604, p=0.010), while it independently predicted TG at baseline. Circulating fetuin-A did not change during the 6 months either in the whole population or in the subgroups of patients who were positive for each individual component of MetS at baseline and negative for this component at 6 months of follow-up, except for hypertriglyceridaemia [reduction of serum fetuin-A levels (p=0.046)]. The subgroup of patients with a decrease in circulating fetuin-A during the 6 months was characterized by a smaller reduction of serum globulins (p=0.003) and CRP (p=0.049). The change in serum fetuin-A levels over the 6 months was positively correlated with the change in TG (r=0.592, p=0.006) and negatively correlated with the change in serum globulins (r=-0.523, p=0.018) and CRP (r=-.494, p=0.037). CONCLUSIONS: Circulating fetuin-A predicted serum triglycerides before as well as 6 months after bariatric surgery. |
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Serum Fetuin-A Levels Are Associated with Serum Triglycerides Before and 6 Months after Bariatric SurgeryHCC ENDAdiposity/physiologyBariatric SurgeryBody Mass IndexMetabolic Syndrome/bloodObesity, Morbid/bloodObesity, Morbid/surgeryPostoperative PeriodTriglycerides/bloodalpha-2-HS-Glycoprotein/metabolismOBJECTIVE: The elucidation of the changes of fetuin-A in the context of bariatric surgery. DESIGN: Twenty obese patients (8 males, 12 females; body mass index = 42.5±3.4 kg/m2) were studied at baseline and 6 months after bariatric surgery. RESULTS: Serum fetuin-A levels did not differ with regard to the presence of each individual component of the Metabolic Syndrome (MetS) at baseline, except for hypertriglyceridaemia [increased serum fetuin-A levels (p=0.011)]. Circulating fetuin-A was positively correlated with serum triglycerides (TG) (r=0.461, p=0.047) and negatively correlated with serum globulins (r=-0.477, p=0.033) and C-reactive protein (CRP) (r=-0.604, p=0.010), while it independently predicted TG at baseline. Circulating fetuin-A did not change during the 6 months either in the whole population or in the subgroups of patients who were positive for each individual component of MetS at baseline and negative for this component at 6 months of follow-up, except for hypertriglyceridaemia [reduction of serum fetuin-A levels (p=0.046)]. The subgroup of patients with a decrease in circulating fetuin-A during the 6 months was characterized by a smaller reduction of serum globulins (p=0.003) and CRP (p=0.049). The change in serum fetuin-A levels over the 6 months was positively correlated with the change in TG (r=0.592, p=0.006) and negatively correlated with the change in serum globulins (r=-0.523, p=0.018) and CRP (r=-.494, p=0.037). CONCLUSIONS: Circulating fetuin-A predicted serum triglycerides before as well as 6 months after bariatric surgery.Hellenic Endocrine SocietyRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEVerras, CGChristou, GASimos, YVAyiomamitis, GDMelidonis, AJKiortsis, DN2018-03-02T16:33:39Z2017-072017-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2929engHormones (Athens). 2017 Jul;16(3):297-305.10.14310/horm.2002.1739info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:40:22Zoai:repositorio.chlc.min-saude.pt:10400.17/2929Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:15.321354Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Serum Fetuin-A Levels Are Associated with Serum Triglycerides Before and 6 Months after Bariatric Surgery |
title |
Serum Fetuin-A Levels Are Associated with Serum Triglycerides Before and 6 Months after Bariatric Surgery |
spellingShingle |
Serum Fetuin-A Levels Are Associated with Serum Triglycerides Before and 6 Months after Bariatric Surgery Verras, CG HCC END Adiposity/physiology Bariatric Surgery Body Mass Index Metabolic Syndrome/blood Obesity, Morbid/blood Obesity, Morbid/surgery Postoperative Period Triglycerides/blood alpha-2-HS-Glycoprotein/metabolism |
title_short |
Serum Fetuin-A Levels Are Associated with Serum Triglycerides Before and 6 Months after Bariatric Surgery |
title_full |
Serum Fetuin-A Levels Are Associated with Serum Triglycerides Before and 6 Months after Bariatric Surgery |
title_fullStr |
Serum Fetuin-A Levels Are Associated with Serum Triglycerides Before and 6 Months after Bariatric Surgery |
title_full_unstemmed |
Serum Fetuin-A Levels Are Associated with Serum Triglycerides Before and 6 Months after Bariatric Surgery |
title_sort |
Serum Fetuin-A Levels Are Associated with Serum Triglycerides Before and 6 Months after Bariatric Surgery |
author |
Verras, CG |
author_facet |
Verras, CG Christou, GA Simos, YV Ayiomamitis, GD Melidonis, AJ Kiortsis, DN |
author_role |
author |
author2 |
Christou, GA Simos, YV Ayiomamitis, GD Melidonis, AJ Kiortsis, DN |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Verras, CG Christou, GA Simos, YV Ayiomamitis, GD Melidonis, AJ Kiortsis, DN |
dc.subject.por.fl_str_mv |
HCC END Adiposity/physiology Bariatric Surgery Body Mass Index Metabolic Syndrome/blood Obesity, Morbid/blood Obesity, Morbid/surgery Postoperative Period Triglycerides/blood alpha-2-HS-Glycoprotein/metabolism |
topic |
HCC END Adiposity/physiology Bariatric Surgery Body Mass Index Metabolic Syndrome/blood Obesity, Morbid/blood Obesity, Morbid/surgery Postoperative Period Triglycerides/blood alpha-2-HS-Glycoprotein/metabolism |
description |
OBJECTIVE: The elucidation of the changes of fetuin-A in the context of bariatric surgery. DESIGN: Twenty obese patients (8 males, 12 females; body mass index = 42.5±3.4 kg/m2) were studied at baseline and 6 months after bariatric surgery. RESULTS: Serum fetuin-A levels did not differ with regard to the presence of each individual component of the Metabolic Syndrome (MetS) at baseline, except for hypertriglyceridaemia [increased serum fetuin-A levels (p=0.011)]. Circulating fetuin-A was positively correlated with serum triglycerides (TG) (r=0.461, p=0.047) and negatively correlated with serum globulins (r=-0.477, p=0.033) and C-reactive protein (CRP) (r=-0.604, p=0.010), while it independently predicted TG at baseline. Circulating fetuin-A did not change during the 6 months either in the whole population or in the subgroups of patients who were positive for each individual component of MetS at baseline and negative for this component at 6 months of follow-up, except for hypertriglyceridaemia [reduction of serum fetuin-A levels (p=0.046)]. The subgroup of patients with a decrease in circulating fetuin-A during the 6 months was characterized by a smaller reduction of serum globulins (p=0.003) and CRP (p=0.049). The change in serum fetuin-A levels over the 6 months was positively correlated with the change in TG (r=0.592, p=0.006) and negatively correlated with the change in serum globulins (r=-0.523, p=0.018) and CRP (r=-.494, p=0.037). CONCLUSIONS: Circulating fetuin-A predicted serum triglycerides before as well as 6 months after bariatric surgery. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-07 2017-07-01T00:00:00Z 2018-03-02T16:33:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/2929 |
url |
http://hdl.handle.net/10400.17/2929 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Hormones (Athens). 2017 Jul;16(3):297-305. 10.14310/horm.2002.1739 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hellenic Endocrine Society |
publisher.none.fl_str_mv |
Hellenic Endocrine Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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