Evaluation of the genotoxic potential of graphene nanomaterials

Detalhes bibliográficos
Autor(a) principal: Teixeira, Bruna Sofia Carvalho
Data de Publicação: 2018
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/25161
Resumo: Graphene is a purely carbon-based, honeycomb-structured, one-atom thick layer of carbon atoms, bonded to another by sp2 hybridization and since its isolation, its unique properties such as high surface area, electrical and thermal conductivities have been widely studied. Graphene and graphene-based nanomaterials are now applied in several fields, as for instance medicine, electronics, sensors and environment. Despite the wide application of graphene nanomaterials, the information on the risks to human health and the environment are not yet well known. Consequently, it is important to investigate and evaluate the potential toxicity of graphene. This thesis revises the applications and toxicity of Graphene-Family Nanomaterials (GFNs) to human cells. Also, the assays for in vitro evaluation of genotoxic effects were also shortly revised. The relevance of the evaluation of potential genotoxic effects of GFNs is highlighted in this thesis.
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spelling Evaluation of the genotoxic potential of graphene nanomaterialsGrapheneCitotoxicityGenotoxicityRAW264.7 cell lineCell CultureGraphene is a purely carbon-based, honeycomb-structured, one-atom thick layer of carbon atoms, bonded to another by sp2 hybridization and since its isolation, its unique properties such as high surface area, electrical and thermal conductivities have been widely studied. Graphene and graphene-based nanomaterials are now applied in several fields, as for instance medicine, electronics, sensors and environment. Despite the wide application of graphene nanomaterials, the information on the risks to human health and the environment are not yet well known. Consequently, it is important to investigate and evaluate the potential toxicity of graphene. This thesis revises the applications and toxicity of Graphene-Family Nanomaterials (GFNs) to human cells. Also, the assays for in vitro evaluation of genotoxic effects were also shortly revised. The relevance of the evaluation of potential genotoxic effects of GFNs is highlighted in this thesis.O Grafeno é constituído por uma única camada de átomos de carbono, estruturada em forma hexagonal com os átomos de carbono ligados por hibridação sp2 e, desde o seu isolamento as suas propriedades únicas, tais como, grande área superficial, condutividade elétrica e térmica, têm sido bastante estudadas. Os nanomateriais de grafeno e os que são à base de grafeno são atualmente aplicados em várias áreas, tais como medicina, eletrónica, sensores e ambiente. Apesar da ampla aplicação dos nanomateriais de grafeno, as informações sobre os riscos para a saúde humana e o meio ambiente não são ainda bem conhecidas. Consequentemente, é importante investigar e avaliar a potencial toxicidade do grafeno. Esta tese revê as aplicações e a toxicidade da Família dos Nanomateriais de Grafeno (GFNs) em células humanas. Além disso, os ensaios para a avaliação in vitro dos efeitos genotóxicos também foram brevemente revistos. A relevância da avaliação dos potenciais efeitos genotóxicos das GFNs é destacada nesta tese.2019-01-18T13:30:27Z2018-12-12T00:00:00Z2018-12-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10773/25161TID:202233022engTeixeira, Bruna Sofia Carvalhoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-06T04:18:51Zoai:ria.ua.pt:10773/25161Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-06T04:18:51Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evaluation of the genotoxic potential of graphene nanomaterials
title Evaluation of the genotoxic potential of graphene nanomaterials
spellingShingle Evaluation of the genotoxic potential of graphene nanomaterials
Teixeira, Bruna Sofia Carvalho
Graphene
Citotoxicity
Genotoxicity
RAW264.7 cell line
Cell Culture
title_short Evaluation of the genotoxic potential of graphene nanomaterials
title_full Evaluation of the genotoxic potential of graphene nanomaterials
title_fullStr Evaluation of the genotoxic potential of graphene nanomaterials
title_full_unstemmed Evaluation of the genotoxic potential of graphene nanomaterials
title_sort Evaluation of the genotoxic potential of graphene nanomaterials
author Teixeira, Bruna Sofia Carvalho
author_facet Teixeira, Bruna Sofia Carvalho
author_role author
dc.contributor.author.fl_str_mv Teixeira, Bruna Sofia Carvalho
dc.subject.por.fl_str_mv Graphene
Citotoxicity
Genotoxicity
RAW264.7 cell line
Cell Culture
topic Graphene
Citotoxicity
Genotoxicity
RAW264.7 cell line
Cell Culture
description Graphene is a purely carbon-based, honeycomb-structured, one-atom thick layer of carbon atoms, bonded to another by sp2 hybridization and since its isolation, its unique properties such as high surface area, electrical and thermal conductivities have been widely studied. Graphene and graphene-based nanomaterials are now applied in several fields, as for instance medicine, electronics, sensors and environment. Despite the wide application of graphene nanomaterials, the information on the risks to human health and the environment are not yet well known. Consequently, it is important to investigate and evaluate the potential toxicity of graphene. This thesis revises the applications and toxicity of Graphene-Family Nanomaterials (GFNs) to human cells. Also, the assays for in vitro evaluation of genotoxic effects were also shortly revised. The relevance of the evaluation of potential genotoxic effects of GFNs is highlighted in this thesis.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-12T00:00:00Z
2018-12-12
2019-01-18T13:30:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/25161
TID:202233022
url http://hdl.handle.net/10773/25161
identifier_str_mv TID:202233022
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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