Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: initial application to the GENFI cohort
| Autor(a) principal: | |
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| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/54194 |
Resumo: | © 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
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Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: initial application to the GENFI cohortClusteringComputational anatomyParallel transportShape analysisSpatiotemporal geodesic regressionThalamus© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such as frontotemporal dementia or Alzheimer's disease, atrophy can be observed in key brain structures years before any clinical symptoms are present. Atrophy is most commonly captured as volume change of key structures and the shape changes of these structures are typically not analysed despite being potentially more sensitive than summary volume statistics over the entire structure. In this paper we propose a spatiotemporal analysis pipeline based on Large Diffeomorphic Deformation Metric Mapping (LDDMM) to detect shape changes from volumetric MRI scans. We applied our framework to a cohort of individuals with genetic variants of frontotemporal dementia and healthy controls from the Genetic FTD Initiative (GENFI) study. Our method, take full advantage of the LDDMM framework, and relies on the creation of a population specific average spatiotemporal trajectory of a relevant brain structure of interest, the thalamus in our case. The residuals from each patient data to the average spatiotemporal trajectory are then clustered and studied to assess when presymptomatic mutation carriers differ from healthy control subjects. We found statistical differences in shape in the anterior region of the thalamus at least five years before the mutation carrier subjects develop any clinical symptoms. This region of the thalamus has been shown to be predominantly connected to the frontal lobe, consistent with the pattern of cortical atrophy seen in the disease.Claire Cury is supported by the EU-FP7 project VPH-DARE@IT (FP7-ICT-2011-9-601055). Stanley Durrleman has received funding from the program Investissements d'avenir ANR-10-IAIHU-06 and the European Unions Horizon 2020 research and innovation programme EuroPOND under grant agreement No 666992, and is funded by the European Research Council (ERC) under grant agreement No 678304. Marco Lorenzi received funding from the EPSRC (EP/J020990/1). Jennifer Nicholas is supported by UK Medical Research Council (grant MR/M023664/1). David Cash is supported by grants from the Alzheimer Society (AS-PG-15-025), Alzheimer’s Research UK (ARUK-PG2014-1946) and Medical Research Council UK (MR/M023664/1). JBR is supported by the Wellcome Trust (103838). Jonathan D. Rohrer is an MRC Clinician Scientist and has received funding from the NIHR Rare Diseases Translational Research Collaboration. Sebastien Ourselin receives funding from the EPSRC (EP/H046410/1, EP/K005278), the MRC (MR/J01107X/1), the NIHR Biomedical Research Unit (Dementia) at UCL and the National Institute for Health Research University College London Hospitals Biomedical Research Centre (NIHR BRC UCLH/UCL High Impact Initiative- BW.mn.BRC10269). Marc Modat is supported by the UCL Leonard Wolfson Experimental Neurology Centre (PR/ylr/18575) and Alzheimer's Society UK (AS-PG-15-025).ElsevierRepositório da Universidade de LisboaCury, ClaireDurrleman, StanleyCash, David M.Lorenzi, MarcoNicholas, Jennifer M.Bocchetta, Martinavan Swieten, John C.Borroni, BarbaraGalimberti, DanielaMasellis, MarioTartaglia, Maria CarmelaRowe, James B.Graff, CarolineTagliavini, FabrizioFrisoni, Giovanni B.Laforce, RobertFinger, ElizabethDe Mendonça, AlexandreSorbi, SandroOurselin, SebastienRohrer, Jonathan D.Modat, MarcAndersson, ChristinArchetti, SilvanaArighi, AndreaBenussi, LuisaBlack, SandraCosseddu, MauraFallstrm, MarieFerreira, CarlosFenoglio, ChiaraFox, NickFreedman, MorrisFumagalli, GiorgioGazzina, StefanoGhidoni, RobertaGrisoli, MarinaJelic, VesnaJiskoot, LizeKeren, RonLombardi, GemmaMaruta, CarolinaMeeter, Liekevan Minkelen, RickNacmias, Benedettaijerstedt, LinnPadovani, AlessandroPanman, JessicaPievani, MichelaPolito, CristinaPremi, EnricoPrioni, SaraRademakers, RosaRedaelli, VeronicaRogaeva, EkaterinaRossi, GiacominaRossor, MartinScarpini, ElioTang-Wai, DavidTartaglia, CarmelaThonberg, HakanTiraboschi, PietroVerdelho, AnaWarren, Jason2022-08-25T11:09:56Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54194engNeuroimage. 2019 Mar;188:282-2901053-811910.1016/j.neuroimage.2018.11.0631095-9572info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:59:48Zoai:repositorio.ul.pt:10451/54194Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:41.434375Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: initial application to the GENFI cohort |
| title |
Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: initial application to the GENFI cohort |
| spellingShingle |
Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: initial application to the GENFI cohort Cury, Claire Clustering Computational anatomy Parallel transport Shape analysis Spatiotemporal geodesic regression Thalamus |
| title_short |
Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: initial application to the GENFI cohort |
| title_full |
Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: initial application to the GENFI cohort |
| title_fullStr |
Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: initial application to the GENFI cohort |
| title_full_unstemmed |
Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: initial application to the GENFI cohort |
| title_sort |
Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: initial application to the GENFI cohort |
| author |
Cury, Claire |
| author_facet |
Cury, Claire Durrleman, Stanley Cash, David M. Lorenzi, Marco Nicholas, Jennifer M. Bocchetta, Martina van Swieten, John C. Borroni, Barbara Galimberti, Daniela Masellis, Mario Tartaglia, Maria Carmela Rowe, James B. Graff, Caroline Tagliavini, Fabrizio Frisoni, Giovanni B. Laforce, Robert Finger, Elizabeth De Mendonça, Alexandre Sorbi, Sandro Ourselin, Sebastien Rohrer, Jonathan D. Modat, Marc Andersson, Christin Archetti, Silvana Arighi, Andrea Benussi, Luisa Black, Sandra Cosseddu, Maura Fallstrm, Marie Ferreira, Carlos Fenoglio, Chiara Fox, Nick Freedman, Morris Fumagalli, Giorgio Gazzina, Stefano Ghidoni, Roberta Grisoli, Marina Jelic, Vesna Jiskoot, Lize Keren, Ron Lombardi, Gemma Maruta, Carolina Meeter, Lieke van Minkelen, Rick Nacmias, Benedetta ijerstedt, Linn Padovani, Alessandro Panman, Jessica Pievani, Michela Polito, Cristina Premi, Enrico Prioni, Sara Rademakers, Rosa Redaelli, Veronica Rogaeva, Ekaterina Rossi, Giacomina Rossor, Martin Scarpini, Elio Tang-Wai, David Tartaglia, Carmela Thonberg, Hakan Tiraboschi, Pietro Verdelho, Ana Warren, Jason |
| author_role |
author |
| author2 |
Durrleman, Stanley Cash, David M. Lorenzi, Marco Nicholas, Jennifer M. Bocchetta, Martina van Swieten, John C. Borroni, Barbara Galimberti, Daniela Masellis, Mario Tartaglia, Maria Carmela Rowe, James B. Graff, Caroline Tagliavini, Fabrizio Frisoni, Giovanni B. Laforce, Robert Finger, Elizabeth De Mendonça, Alexandre Sorbi, Sandro Ourselin, Sebastien Rohrer, Jonathan D. Modat, Marc Andersson, Christin Archetti, Silvana Arighi, Andrea Benussi, Luisa Black, Sandra Cosseddu, Maura Fallstrm, Marie Ferreira, Carlos Fenoglio, Chiara Fox, Nick Freedman, Morris Fumagalli, Giorgio Gazzina, Stefano Ghidoni, Roberta Grisoli, Marina Jelic, Vesna Jiskoot, Lize Keren, Ron Lombardi, Gemma Maruta, Carolina Meeter, Lieke van Minkelen, Rick Nacmias, Benedetta ijerstedt, Linn Padovani, Alessandro Panman, Jessica Pievani, Michela Polito, Cristina Premi, Enrico Prioni, Sara Rademakers, Rosa Redaelli, Veronica Rogaeva, Ekaterina Rossi, Giacomina Rossor, Martin Scarpini, Elio Tang-Wai, David Tartaglia, Carmela Thonberg, Hakan Tiraboschi, Pietro Verdelho, Ana Warren, Jason |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Cury, Claire Durrleman, Stanley Cash, David M. Lorenzi, Marco Nicholas, Jennifer M. Bocchetta, Martina van Swieten, John C. Borroni, Barbara Galimberti, Daniela Masellis, Mario Tartaglia, Maria Carmela Rowe, James B. Graff, Caroline Tagliavini, Fabrizio Frisoni, Giovanni B. Laforce, Robert Finger, Elizabeth De Mendonça, Alexandre Sorbi, Sandro Ourselin, Sebastien Rohrer, Jonathan D. Modat, Marc Andersson, Christin Archetti, Silvana Arighi, Andrea Benussi, Luisa Black, Sandra Cosseddu, Maura Fallstrm, Marie Ferreira, Carlos Fenoglio, Chiara Fox, Nick Freedman, Morris Fumagalli, Giorgio Gazzina, Stefano Ghidoni, Roberta Grisoli, Marina Jelic, Vesna Jiskoot, Lize Keren, Ron Lombardi, Gemma Maruta, Carolina Meeter, Lieke van Minkelen, Rick Nacmias, Benedetta ijerstedt, Linn Padovani, Alessandro Panman, Jessica Pievani, Michela Polito, Cristina Premi, Enrico Prioni, Sara Rademakers, Rosa Redaelli, Veronica Rogaeva, Ekaterina Rossi, Giacomina Rossor, Martin Scarpini, Elio Tang-Wai, David Tartaglia, Carmela Thonberg, Hakan Tiraboschi, Pietro Verdelho, Ana Warren, Jason |
| dc.subject.por.fl_str_mv |
Clustering Computational anatomy Parallel transport Shape analysis Spatiotemporal geodesic regression Thalamus |
| topic |
Clustering Computational anatomy Parallel transport Shape analysis Spatiotemporal geodesic regression Thalamus |
| description |
© 2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2022-08-25T11:09:56Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/54194 |
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http://hdl.handle.net/10451/54194 |
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eng |
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eng |
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Neuroimage. 2019 Mar;188:282-290 1053-8119 10.1016/j.neuroimage.2018.11.063 1095-9572 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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