Magnetoliposomes based on shape anisotropic calcium/magnesium ferrite nanoparticles as nanocarriers for doxorubicin
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/73922 |
Resumo: | Multifunctional lipid nanocarriers are a promising therapeutic approach for controlled drug release in cancer therapy. Combining the widely used liposome structure with magnetic nanoparticles in magnetoliposomes allies, the advantages of using liposomes include the possibility to magnetically guide, selectively accumulate, and magnetically control the release of drugs on target. The effectiveness of these nanosystems is intrinsically related to the individual characteristics of the two main components-lipid formulation and magnetic nanoparticles-and their physicochemical combination. Herein, shape-anisotropic calcium-substituted magnesium ferrite nanoparticles (Ca0.25Mg0.75Fe2O4) were prepared for the first time, improving the magnetic properties of spherical counterparts. The nanoparticles revealed a superparamagnetic behavior, high saturation magnetization (50.07 emu/g at 300 K), and a large heating capacity. Furthermore, a new method for the synthesis of solid magnetoliposomes (SMLs) was developed to enhance their magnetic response. The manufacturing technicalities were optimized with different lipid compositions (DPPC, DPPC/Ch, and DPPC/DSPE-PEG) originating nanosystems with optimal sizes for biomedical applications (around or below 150 nm) and low polydispersity index. The high encapsulation efficiency of doxorubicin in these magnetoliposomes was proven, as well as the ability of the drug-loaded nanosystems to interact with cell membrane models and release DOX by fusion. SMLs revealed to reduce doxorubicin interaction with human serum albumin, contributing to a prolonged bioavailability of the drug upon systemic administration. Finally, the drug release kinetic assays revealed a preferable DOX release at hyperthermia temperatures (42 °C) and acidic conditions (pH = 5.5), indicating them as promising controlled release nanocarriers by either internal (pH) and external (alternate magnetic field) stimuli in cancer therapy. |
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Magnetoliposomes based on shape anisotropic calcium/magnesium ferrite nanoparticles as nanocarriers for doxorubicinmagnetic nanoparticlesmagnetoliposomescancer therapyshape-anisotropymixed ferritesmagnetic hyperthermiadoxorubicinEngenharia e Tecnologia::NanotecnologiaScience & TechnologySaúde de qualidadeMultifunctional lipid nanocarriers are a promising therapeutic approach for controlled drug release in cancer therapy. Combining the widely used liposome structure with magnetic nanoparticles in magnetoliposomes allies, the advantages of using liposomes include the possibility to magnetically guide, selectively accumulate, and magnetically control the release of drugs on target. The effectiveness of these nanosystems is intrinsically related to the individual characteristics of the two main components-lipid formulation and magnetic nanoparticles-and their physicochemical combination. Herein, shape-anisotropic calcium-substituted magnesium ferrite nanoparticles (Ca0.25Mg0.75Fe2O4) were prepared for the first time, improving the magnetic properties of spherical counterparts. The nanoparticles revealed a superparamagnetic behavior, high saturation magnetization (50.07 emu/g at 300 K), and a large heating capacity. Furthermore, a new method for the synthesis of solid magnetoliposomes (SMLs) was developed to enhance their magnetic response. The manufacturing technicalities were optimized with different lipid compositions (DPPC, DPPC/Ch, and DPPC/DSPE-PEG) originating nanosystems with optimal sizes for biomedical applications (around or below 150 nm) and low polydispersity index. The high encapsulation efficiency of doxorubicin in these magnetoliposomes was proven, as well as the ability of the drug-loaded nanosystems to interact with cell membrane models and release DOX by fusion. SMLs revealed to reduce doxorubicin interaction with human serum albumin, contributing to a prolonged bioavailability of the drug upon systemic administration. Finally, the drug release kinetic assays revealed a preferable DOX release at hyperthermia temperatures (42 °C) and acidic conditions (pH = 5.5), indicating them as promising controlled release nanocarriers by either internal (pH) and external (alternate magnetic field) stimuli in cancer therapy.This research was funded by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UIDB/04650/2020) and through the research project PTDC/QUI-QFI/28020/2017 (POCI-01-0145-FEDER-028020), co-financed by European Fund of Regional Development (FEDER), COMPETE2020 and Portugal2020. B.D.C. acknowledges FCT for a PhD grant (SFRH/BD/141936/2018).Multidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoCardoso, Beatriz D.Rodrigues, Ana Rita OliveiraBañobre-López, ManuelAlmeida, B. G.Amorim, Carlos O.Amaral, Vítor S.Coutinho, Paulo J. G.Castanheira, Elisabete M. S.2021-08-122021-08-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/1822/73922engCardoso, B.D.; Rodrigues, A.R.O.; Bañobre-López, M.; Almeida, B.G.; Amorim, C.O.; Amaral, V.S.; Coutinho, P.J.G.; Castanheira, E.M.S. Magnetoliposomes Based on Shape Anisotropic Calcium/Magnesium Ferrite Nanoparticles as Nanocarriers for Doxorubicin. Pharmaceutics 2021, 13, 1248. https://doi.org/10.3390/pharmaceutics130812481999-492310.3390/pharmaceutics13081248https://www.mdpi.com/1999-4923/13/8/1248info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:23:44Zoai:repositorium.sdum.uminho.pt:1822/73922Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:17:32.986832Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Magnetoliposomes based on shape anisotropic calcium/magnesium ferrite nanoparticles as nanocarriers for doxorubicin |
title |
Magnetoliposomes based on shape anisotropic calcium/magnesium ferrite nanoparticles as nanocarriers for doxorubicin |
spellingShingle |
Magnetoliposomes based on shape anisotropic calcium/magnesium ferrite nanoparticles as nanocarriers for doxorubicin Cardoso, Beatriz D. magnetic nanoparticles magnetoliposomes cancer therapy shape-anisotropy mixed ferrites magnetic hyperthermia doxorubicin Engenharia e Tecnologia::Nanotecnologia Science & Technology Saúde de qualidade |
title_short |
Magnetoliposomes based on shape anisotropic calcium/magnesium ferrite nanoparticles as nanocarriers for doxorubicin |
title_full |
Magnetoliposomes based on shape anisotropic calcium/magnesium ferrite nanoparticles as nanocarriers for doxorubicin |
title_fullStr |
Magnetoliposomes based on shape anisotropic calcium/magnesium ferrite nanoparticles as nanocarriers for doxorubicin |
title_full_unstemmed |
Magnetoliposomes based on shape anisotropic calcium/magnesium ferrite nanoparticles as nanocarriers for doxorubicin |
title_sort |
Magnetoliposomes based on shape anisotropic calcium/magnesium ferrite nanoparticles as nanocarriers for doxorubicin |
author |
Cardoso, Beatriz D. |
author_facet |
Cardoso, Beatriz D. Rodrigues, Ana Rita Oliveira Bañobre-López, Manuel Almeida, B. G. Amorim, Carlos O. Amaral, Vítor S. Coutinho, Paulo J. G. Castanheira, Elisabete M. S. |
author_role |
author |
author2 |
Rodrigues, Ana Rita Oliveira Bañobre-López, Manuel Almeida, B. G. Amorim, Carlos O. Amaral, Vítor S. Coutinho, Paulo J. G. Castanheira, Elisabete M. S. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Cardoso, Beatriz D. Rodrigues, Ana Rita Oliveira Bañobre-López, Manuel Almeida, B. G. Amorim, Carlos O. Amaral, Vítor S. Coutinho, Paulo J. G. Castanheira, Elisabete M. S. |
dc.subject.por.fl_str_mv |
magnetic nanoparticles magnetoliposomes cancer therapy shape-anisotropy mixed ferrites magnetic hyperthermia doxorubicin Engenharia e Tecnologia::Nanotecnologia Science & Technology Saúde de qualidade |
topic |
magnetic nanoparticles magnetoliposomes cancer therapy shape-anisotropy mixed ferrites magnetic hyperthermia doxorubicin Engenharia e Tecnologia::Nanotecnologia Science & Technology Saúde de qualidade |
description |
Multifunctional lipid nanocarriers are a promising therapeutic approach for controlled drug release in cancer therapy. Combining the widely used liposome structure with magnetic nanoparticles in magnetoliposomes allies, the advantages of using liposomes include the possibility to magnetically guide, selectively accumulate, and magnetically control the release of drugs on target. The effectiveness of these nanosystems is intrinsically related to the individual characteristics of the two main components-lipid formulation and magnetic nanoparticles-and their physicochemical combination. Herein, shape-anisotropic calcium-substituted magnesium ferrite nanoparticles (Ca0.25Mg0.75Fe2O4) were prepared for the first time, improving the magnetic properties of spherical counterparts. The nanoparticles revealed a superparamagnetic behavior, high saturation magnetization (50.07 emu/g at 300 K), and a large heating capacity. Furthermore, a new method for the synthesis of solid magnetoliposomes (SMLs) was developed to enhance their magnetic response. The manufacturing technicalities were optimized with different lipid compositions (DPPC, DPPC/Ch, and DPPC/DSPE-PEG) originating nanosystems with optimal sizes for biomedical applications (around or below 150 nm) and low polydispersity index. The high encapsulation efficiency of doxorubicin in these magnetoliposomes was proven, as well as the ability of the drug-loaded nanosystems to interact with cell membrane models and release DOX by fusion. SMLs revealed to reduce doxorubicin interaction with human serum albumin, contributing to a prolonged bioavailability of the drug upon systemic administration. Finally, the drug release kinetic assays revealed a preferable DOX release at hyperthermia temperatures (42 °C) and acidic conditions (pH = 5.5), indicating them as promising controlled release nanocarriers by either internal (pH) and external (alternate magnetic field) stimuli in cancer therapy. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-12 2021-08-12T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/73922 |
url |
http://hdl.handle.net/1822/73922 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cardoso, B.D.; Rodrigues, A.R.O.; Bañobre-López, M.; Almeida, B.G.; Amorim, C.O.; Amaral, V.S.; Coutinho, P.J.G.; Castanheira, E.M.S. Magnetoliposomes Based on Shape Anisotropic Calcium/Magnesium Ferrite Nanoparticles as Nanocarriers for Doxorubicin. Pharmaceutics 2021, 13, 1248. https://doi.org/10.3390/pharmaceutics13081248 1999-4923 10.3390/pharmaceutics13081248 https://www.mdpi.com/1999-4923/13/8/1248 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132627617185792 |