Fungal vaccines and immunotherapeutics: current concepts and future challenges
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/48553 |
Resumo: | Purpose of review The remarkable advances in modern medicine have paradoxically resulted in a rapidly expanding population of immunocompromised patients displaying extreme susceptibility to life-threatening fungal infections. There are currently no licensed vaccines, and the prophylaxis and therapy of fungal infections in at-risk individuals remains challenging, contributing to undesirable mortality and morbidity rates. The design of successful antifungal preventive approaches has been hampered by an insufficient understanding of the dynamics of the host-fungus interaction and the mechanisms that underlie heterogenous immune responses to vaccines and immunotherapy. Recent findings Recent advances in proteomics and glycomics have contributed to the identification of candidate antigens for use in subunit vaccines, novel adjuvants, and delivery systems to boost the efficacy of protective vaccination responses that are becoming available, and several targets are being exploited in immunotherapeutic approaches. Summary We review some of the emerging concepts as well as the inherent challenges to the development of fungal vaccines and immunotherapies to protect at-risk individuals. |
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Fungal vaccines and immunotherapeutics: current concepts and future challengesFungal diseaseVaccinationAspergillusCandidaImmunotherapyPersonalized medicineCiências Médicas::Ciências da SaúdeScience & TechnologyPurpose of review The remarkable advances in modern medicine have paradoxically resulted in a rapidly expanding population of immunocompromised patients displaying extreme susceptibility to life-threatening fungal infections. There are currently no licensed vaccines, and the prophylaxis and therapy of fungal infections in at-risk individuals remains challenging, contributing to undesirable mortality and morbidity rates. The design of successful antifungal preventive approaches has been hampered by an insufficient understanding of the dynamics of the host-fungus interaction and the mechanisms that underlie heterogenous immune responses to vaccines and immunotherapy. Recent findings Recent advances in proteomics and glycomics have contributed to the identification of candidate antigens for use in subunit vaccines, novel adjuvants, and delivery systems to boost the efficacy of protective vaccination responses that are becoming available, and several targets are being exploited in immunotherapeutic approaches. Summary We review some of the emerging concepts as well as the inherent challenges to the development of fungal vaccines and immunotherapies to protect at-risk individuals.ThisworkwassupportedbytheNorthernPortugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013), and the Fundação para a Ciência e Tecnologia (FCT) (contracts IF/00735/ 2014 to A.C., and SFRH/BPD/96176/2013 to C.C).info:eu-repo/semantics/publishedVersionSpringerUniversidade do MinhoCarvalho, Agostinho Albérico RodriguesOliveira, Cláudio DuarteGonçalves, Samuel M.Campos Jr., AntónioLacerda, João F.Cunha, Cristina20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/48553engCarvalho, A., Duarte-Oliveira, C., Gonçalves, S. M., Campos, A., Lacerda, J. F., & Cunha, C. (2017). Fungal Vaccines and Immunotherapeutics: Current Concepts and Future Challenges. [Review]. Current Fungal Infection Reports, 11(1), 16-24. doi: 10.1007/s12281-017-0272-y1936-376110.1007/s12281-017-0272-yhttps://link.springer.com/journal/12281info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:49:30Zoai:repositorium.sdum.uminho.pt:1822/48553Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:47:59.947751Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fungal vaccines and immunotherapeutics: current concepts and future challenges |
title |
Fungal vaccines and immunotherapeutics: current concepts and future challenges |
spellingShingle |
Fungal vaccines and immunotherapeutics: current concepts and future challenges Carvalho, Agostinho Albérico Rodrigues Fungal disease Vaccination Aspergillus Candida Immunotherapy Personalized medicine Ciências Médicas::Ciências da Saúde Science & Technology |
title_short |
Fungal vaccines and immunotherapeutics: current concepts and future challenges |
title_full |
Fungal vaccines and immunotherapeutics: current concepts and future challenges |
title_fullStr |
Fungal vaccines and immunotherapeutics: current concepts and future challenges |
title_full_unstemmed |
Fungal vaccines and immunotherapeutics: current concepts and future challenges |
title_sort |
Fungal vaccines and immunotherapeutics: current concepts and future challenges |
author |
Carvalho, Agostinho Albérico Rodrigues |
author_facet |
Carvalho, Agostinho Albérico Rodrigues Oliveira, Cláudio Duarte Gonçalves, Samuel M. Campos Jr., António Lacerda, João F. Cunha, Cristina |
author_role |
author |
author2 |
Oliveira, Cláudio Duarte Gonçalves, Samuel M. Campos Jr., António Lacerda, João F. Cunha, Cristina |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Carvalho, Agostinho Albérico Rodrigues Oliveira, Cláudio Duarte Gonçalves, Samuel M. Campos Jr., António Lacerda, João F. Cunha, Cristina |
dc.subject.por.fl_str_mv |
Fungal disease Vaccination Aspergillus Candida Immunotherapy Personalized medicine Ciências Médicas::Ciências da Saúde Science & Technology |
topic |
Fungal disease Vaccination Aspergillus Candida Immunotherapy Personalized medicine Ciências Médicas::Ciências da Saúde Science & Technology |
description |
Purpose of review The remarkable advances in modern medicine have paradoxically resulted in a rapidly expanding population of immunocompromised patients displaying extreme susceptibility to life-threatening fungal infections. There are currently no licensed vaccines, and the prophylaxis and therapy of fungal infections in at-risk individuals remains challenging, contributing to undesirable mortality and morbidity rates. The design of successful antifungal preventive approaches has been hampered by an insufficient understanding of the dynamics of the host-fungus interaction and the mechanisms that underlie heterogenous immune responses to vaccines and immunotherapy. Recent findings Recent advances in proteomics and glycomics have contributed to the identification of candidate antigens for use in subunit vaccines, novel adjuvants, and delivery systems to boost the efficacy of protective vaccination responses that are becoming available, and several targets are being exploited in immunotherapeutic approaches. Summary We review some of the emerging concepts as well as the inherent challenges to the development of fungal vaccines and immunotherapies to protect at-risk individuals. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2017-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/48553 |
url |
http://hdl.handle.net/1822/48553 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Carvalho, A., Duarte-Oliveira, C., Gonçalves, S. M., Campos, A., Lacerda, J. F., & Cunha, C. (2017). Fungal Vaccines and Immunotherapeutics: Current Concepts and Future Challenges. [Review]. Current Fungal Infection Reports, 11(1), 16-24. doi: 10.1007/s12281-017-0272-y 1936-3761 10.1007/s12281-017-0272-y https://link.springer.com/journal/12281 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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