A dive into the bath: embedded 3D bioprinting of freeform in vitro models
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/88446 |
Resumo: | Designing functional, vascularized, human scale in vitro models with biomimetic architectures and multiple cell types is a highly promising strategy for both a better understanding of natural tissue/organ development stages to inspire regenerative medicine, and to test novel therapeutics on personalized microphysiological systems. Extrusion-based 3D bioprinting is an effective biofabrication technology to engineer living constructs with predefined geometries and cell patterns. However, bioprinting high-resolution multilayered structures with mechanically weak hydrogel bioinks is challenging. The advent of embedded 3D bioprinting systems in recent years offered new avenues to explore this technology for in vitro modeling. By providing a stable, cell-friendly and perfusable environment to hold the bioink during and after printing, it allows to recapitulate native tissues’ architecture and function in a well-controlled manner. Besides enabling freeform bioprinting of constructs with complex spatial organization, support baths can further provide functional housing systems for their long-term in vitro maintenance and screening. This minireview summarizes the recent advances in this field and discuss the enormous potential of embedded 3D bioprinting technologies as alternatives for the automated fabrication of more biomimetic in vitro models. |
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A dive into the bath: embedded 3D bioprinting of freeform in vitro models3D bioprintingIn vitro 3d modelsSupport bathDesigning functional, vascularized, human scale in vitro models with biomimetic architectures and multiple cell types is a highly promising strategy for both a better understanding of natural tissue/organ development stages to inspire regenerative medicine, and to test novel therapeutics on personalized microphysiological systems. Extrusion-based 3D bioprinting is an effective biofabrication technology to engineer living constructs with predefined geometries and cell patterns. However, bioprinting high-resolution multilayered structures with mechanically weak hydrogel bioinks is challenging. The advent of embedded 3D bioprinting systems in recent years offered new avenues to explore this technology for in vitro modeling. By providing a stable, cell-friendly and perfusable environment to hold the bioink during and after printing, it allows to recapitulate native tissues’ architecture and function in a well-controlled manner. Besides enabling freeform bioprinting of constructs with complex spatial organization, support baths can further provide functional housing systems for their long-term in vitro maintenance and screening. This minireview summarizes the recent advances in this field and discuss the enormous potential of embedded 3D bioprinting technologies as alternatives for the automated fabrication of more biomimetic in vitro models.The authors acknowledge the financial support from Project NORTE-01-0145-FEDER 000021 supported by Norte Portugal Regional Operational Program (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), the European Union Framework Program for Research and Innovation HORIZON 2020, under European Research Council Grant Agreement 772817 and 101069302, Fundação para a Ciência e a Tecnologia (FCT) for the for Contract 2020.03410.CEECIND (to R. M. A. D.) and Wi-Pi project 2022.05526.PTDC. The schematics of the Table of Contents graphic was created with BioRender.com.Royal Society of ChemistryUniversidade do MinhoÖztuerk-Öncel, M. Ö.Leal-Martínez, Baltazar HiramMonteiro, Rosa F.Gomes, Manuela E.Domingues, Rui Miguel Andrade2023-072023-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/88446engÖztuerk-Öncel M. Ö., Leal-Martínez B. H., Monteiro R. F., Gomes M. E., Domingues R. M. A. A dive into the bath: embedded 3D bioprinting of freeform in vitro models, Biomaterials Science, Vol. 11, pp. 5462-5473, doi:10.1039/D3BM00626C, 20232047-484910.1039/D3BM00626C37489648https://doi.org/10.1039/D3BM00626Cinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-03T01:21:04Zoai:repositorium.sdum.uminho.pt:1822/88446Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:07:33.295692Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A dive into the bath: embedded 3D bioprinting of freeform in vitro models |
title |
A dive into the bath: embedded 3D bioprinting of freeform in vitro models |
spellingShingle |
A dive into the bath: embedded 3D bioprinting of freeform in vitro models Öztuerk-Öncel, M. Ö. 3D bioprinting In vitro 3d models Support bath |
title_short |
A dive into the bath: embedded 3D bioprinting of freeform in vitro models |
title_full |
A dive into the bath: embedded 3D bioprinting of freeform in vitro models |
title_fullStr |
A dive into the bath: embedded 3D bioprinting of freeform in vitro models |
title_full_unstemmed |
A dive into the bath: embedded 3D bioprinting of freeform in vitro models |
title_sort |
A dive into the bath: embedded 3D bioprinting of freeform in vitro models |
author |
Öztuerk-Öncel, M. Ö. |
author_facet |
Öztuerk-Öncel, M. Ö. Leal-Martínez, Baltazar Hiram Monteiro, Rosa F. Gomes, Manuela E. Domingues, Rui Miguel Andrade |
author_role |
author |
author2 |
Leal-Martínez, Baltazar Hiram Monteiro, Rosa F. Gomes, Manuela E. Domingues, Rui Miguel Andrade |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Öztuerk-Öncel, M. Ö. Leal-Martínez, Baltazar Hiram Monteiro, Rosa F. Gomes, Manuela E. Domingues, Rui Miguel Andrade |
dc.subject.por.fl_str_mv |
3D bioprinting In vitro 3d models Support bath |
topic |
3D bioprinting In vitro 3d models Support bath |
description |
Designing functional, vascularized, human scale in vitro models with biomimetic architectures and multiple cell types is a highly promising strategy for both a better understanding of natural tissue/organ development stages to inspire regenerative medicine, and to test novel therapeutics on personalized microphysiological systems. Extrusion-based 3D bioprinting is an effective biofabrication technology to engineer living constructs with predefined geometries and cell patterns. However, bioprinting high-resolution multilayered structures with mechanically weak hydrogel bioinks is challenging. The advent of embedded 3D bioprinting systems in recent years offered new avenues to explore this technology for in vitro modeling. By providing a stable, cell-friendly and perfusable environment to hold the bioink during and after printing, it allows to recapitulate native tissues’ architecture and function in a well-controlled manner. Besides enabling freeform bioprinting of constructs with complex spatial organization, support baths can further provide functional housing systems for their long-term in vitro maintenance and screening. This minireview summarizes the recent advances in this field and discuss the enormous potential of embedded 3D bioprinting technologies as alternatives for the automated fabrication of more biomimetic in vitro models. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07 2023-07-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/88446 |
url |
https://hdl.handle.net/1822/88446 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Öztuerk-Öncel M. Ö., Leal-Martínez B. H., Monteiro R. F., Gomes M. E., Domingues R. M. A. A dive into the bath: embedded 3D bioprinting of freeform in vitro models, Biomaterials Science, Vol. 11, pp. 5462-5473, doi:10.1039/D3BM00626C, 2023 2047-4849 10.1039/D3BM00626C 37489648 https://doi.org/10.1039/D3BM00626C |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society of Chemistry |
publisher.none.fl_str_mv |
Royal Society of Chemistry |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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