Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio

Detalhes bibliográficos
Autor(a) principal: Mayordomo-Colunga, J
Data de Publicação: 2013
Outros Autores: Pons, M, López, Y, Solana, MJ, Rey, C, Martı´nez-Camblor, P, Rodríguez-Núñez, A, López-Herce, J, Medina, A, Abadesso, C, García-Teresa, MA, et al.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.10/1345
Resumo: PURPOSE: Our objective was to assess whether SpO₂/FiO₂ (SF) ratio could be a useful NIV outcome predictor in children with acute respiratory failure (ARF) and tried to develop a predictive model of NIV failure. METHODS: Prospective, observational, multicenter study. Episodes of ARF-fulfilling inclusion criteria from 15 January 2010 to 14 January 2011 were treated with NIV according to a pre-established protocol. Clinical variables were collected at baseline and at 1, 2, 6, 12 and 24 h. Failure criterion was the need for endotracheal intubation. Failures were considered as "early" if occurring ≤6 h after NIV initiation, "intermediate" if occurring between 6 and 24 h, and "late" if occurring after 24 h. Variables with a p < 0.1 in univariate analysis corrected by age were included in multivariate analysis. Models were calculated based on multivariate analysis. RESULTS: During the study period, 390 episodes were included. NIV success rate was 81.3 %. Among ARF causes, failure occurred most frequently in ARDS episodes. The failure predictive model for the whole sample included SF ratio at 1 h, age and PRISM III-24 (area under the curve AUC of 0.755). For early NIV failures, SF ratio at 1 h was the only variable within model (AUC 0.748). The analysis of intermediate NIV failures identified 3 variables independently linked to NIV outcome: PRISM III-24, RR decrease at 6 h, and SF ratio at 6 h (AUC 0.895). No model was identified for late NIV failure. CONCLUSIONS: SF ratio is a reliable predictor of early NIV failure in children.
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spelling Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratioNoninvasive VentilationRespiratory insufficiencyChildVentilação não invasivaInsuficiência respiratóriaCriançaPURPOSE: Our objective was to assess whether SpO₂/FiO₂ (SF) ratio could be a useful NIV outcome predictor in children with acute respiratory failure (ARF) and tried to develop a predictive model of NIV failure. METHODS: Prospective, observational, multicenter study. Episodes of ARF-fulfilling inclusion criteria from 15 January 2010 to 14 January 2011 were treated with NIV according to a pre-established protocol. Clinical variables were collected at baseline and at 1, 2, 6, 12 and 24 h. Failure criterion was the need for endotracheal intubation. Failures were considered as "early" if occurring ≤6 h after NIV initiation, "intermediate" if occurring between 6 and 24 h, and "late" if occurring after 24 h. Variables with a p < 0.1 in univariate analysis corrected by age were included in multivariate analysis. Models were calculated based on multivariate analysis. RESULTS: During the study period, 390 episodes were included. NIV success rate was 81.3 %. Among ARF causes, failure occurred most frequently in ARDS episodes. The failure predictive model for the whole sample included SF ratio at 1 h, age and PRISM III-24 (area under the curve AUC of 0.755). For early NIV failures, SF ratio at 1 h was the only variable within model (AUC 0.748). The analysis of intermediate NIV failures identified 3 variables independently linked to NIV outcome: PRISM III-24, RR decrease at 6 h, and SF ratio at 6 h (AUC 0.895). No model was identified for late NIV failure. CONCLUSIONS: SF ratio is a reliable predictor of early NIV failure in children.European Society of Intensive Care MedicineRepositório do Hospital Prof. Doutor Fernando FonsecaMayordomo-Colunga, JPons, MLópez, YSolana, MJRey, CMartı´nez-Camblor, PRodríguez-Núñez, ALópez-Herce, JMedina, AAbadesso, CGarcía-Teresa, MA, et al.2015-01-23T15:54:50Z2013-01-01T00:00:00Z2013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.10/1345engIntensive Care Med. 2013 Jun;39(6):1095-10310.1007/s00134-013-2880-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-20T15:52:08Zoai:repositorio.hff.min-saude.pt:10400.10/1345Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:52:26.208675Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio
title Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio
spellingShingle Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio
Mayordomo-Colunga, J
Noninvasive Ventilation
Respiratory insufficiency
Child
Ventilação não invasiva
Insuficiência respiratória
Criança
title_short Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio
title_full Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio
title_fullStr Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio
title_full_unstemmed Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio
title_sort Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio
author Mayordomo-Colunga, J
author_facet Mayordomo-Colunga, J
Pons, M
López, Y
Solana, MJ
Rey, C
Martı´nez-Camblor, P
Rodríguez-Núñez, A
López-Herce, J
Medina, A
Abadesso, C
García-Teresa, MA, et al.
author_role author
author2 Pons, M
López, Y
Solana, MJ
Rey, C
Martı´nez-Camblor, P
Rodríguez-Núñez, A
López-Herce, J
Medina, A
Abadesso, C
García-Teresa, MA, et al.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Hospital Prof. Doutor Fernando Fonseca
dc.contributor.author.fl_str_mv Mayordomo-Colunga, J
Pons, M
López, Y
Solana, MJ
Rey, C
Martı´nez-Camblor, P
Rodríguez-Núñez, A
López-Herce, J
Medina, A
Abadesso, C
García-Teresa, MA, et al.
dc.subject.por.fl_str_mv Noninvasive Ventilation
Respiratory insufficiency
Child
Ventilação não invasiva
Insuficiência respiratória
Criança
topic Noninvasive Ventilation
Respiratory insufficiency
Child
Ventilação não invasiva
Insuficiência respiratória
Criança
description PURPOSE: Our objective was to assess whether SpO₂/FiO₂ (SF) ratio could be a useful NIV outcome predictor in children with acute respiratory failure (ARF) and tried to develop a predictive model of NIV failure. METHODS: Prospective, observational, multicenter study. Episodes of ARF-fulfilling inclusion criteria from 15 January 2010 to 14 January 2011 were treated with NIV according to a pre-established protocol. Clinical variables were collected at baseline and at 1, 2, 6, 12 and 24 h. Failure criterion was the need for endotracheal intubation. Failures were considered as "early" if occurring ≤6 h after NIV initiation, "intermediate" if occurring between 6 and 24 h, and "late" if occurring after 24 h. Variables with a p < 0.1 in univariate analysis corrected by age were included in multivariate analysis. Models were calculated based on multivariate analysis. RESULTS: During the study period, 390 episodes were included. NIV success rate was 81.3 %. Among ARF causes, failure occurred most frequently in ARDS episodes. The failure predictive model for the whole sample included SF ratio at 1 h, age and PRISM III-24 (area under the curve AUC of 0.755). For early NIV failures, SF ratio at 1 h was the only variable within model (AUC 0.748). The analysis of intermediate NIV failures identified 3 variables independently linked to NIV outcome: PRISM III-24, RR decrease at 6 h, and SF ratio at 6 h (AUC 0.895). No model was identified for late NIV failure. CONCLUSIONS: SF ratio is a reliable predictor of early NIV failure in children.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01T00:00:00Z
2013-01-01T00:00:00Z
2015-01-23T15:54:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.10/1345
url http://hdl.handle.net/10400.10/1345
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Intensive Care Med. 2013 Jun;39(6):1095-103
10.1007/s00134-013-2880-5
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv European Society of Intensive Care Medicine
publisher.none.fl_str_mv European Society of Intensive Care Medicine
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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