Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.10/1345 |
Resumo: | PURPOSE: Our objective was to assess whether SpO₂/FiO₂ (SF) ratio could be a useful NIV outcome predictor in children with acute respiratory failure (ARF) and tried to develop a predictive model of NIV failure. METHODS: Prospective, observational, multicenter study. Episodes of ARF-fulfilling inclusion criteria from 15 January 2010 to 14 January 2011 were treated with NIV according to a pre-established protocol. Clinical variables were collected at baseline and at 1, 2, 6, 12 and 24 h. Failure criterion was the need for endotracheal intubation. Failures were considered as "early" if occurring ≤6 h after NIV initiation, "intermediate" if occurring between 6 and 24 h, and "late" if occurring after 24 h. Variables with a p < 0.1 in univariate analysis corrected by age were included in multivariate analysis. Models were calculated based on multivariate analysis. RESULTS: During the study period, 390 episodes were included. NIV success rate was 81.3 %. Among ARF causes, failure occurred most frequently in ARDS episodes. The failure predictive model for the whole sample included SF ratio at 1 h, age and PRISM III-24 (area under the curve AUC of 0.755). For early NIV failures, SF ratio at 1 h was the only variable within model (AUC 0.748). The analysis of intermediate NIV failures identified 3 variables independently linked to NIV outcome: PRISM III-24, RR decrease at 6 h, and SF ratio at 6 h (AUC 0.895). No model was identified for late NIV failure. CONCLUSIONS: SF ratio is a reliable predictor of early NIV failure in children. |
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Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratioNoninvasive VentilationRespiratory insufficiencyChildVentilação não invasivaInsuficiência respiratóriaCriançaPURPOSE: Our objective was to assess whether SpO₂/FiO₂ (SF) ratio could be a useful NIV outcome predictor in children with acute respiratory failure (ARF) and tried to develop a predictive model of NIV failure. METHODS: Prospective, observational, multicenter study. Episodes of ARF-fulfilling inclusion criteria from 15 January 2010 to 14 January 2011 were treated with NIV according to a pre-established protocol. Clinical variables were collected at baseline and at 1, 2, 6, 12 and 24 h. Failure criterion was the need for endotracheal intubation. Failures were considered as "early" if occurring ≤6 h after NIV initiation, "intermediate" if occurring between 6 and 24 h, and "late" if occurring after 24 h. Variables with a p < 0.1 in univariate analysis corrected by age were included in multivariate analysis. Models were calculated based on multivariate analysis. RESULTS: During the study period, 390 episodes were included. NIV success rate was 81.3 %. Among ARF causes, failure occurred most frequently in ARDS episodes. The failure predictive model for the whole sample included SF ratio at 1 h, age and PRISM III-24 (area under the curve AUC of 0.755). For early NIV failures, SF ratio at 1 h was the only variable within model (AUC 0.748). The analysis of intermediate NIV failures identified 3 variables independently linked to NIV outcome: PRISM III-24, RR decrease at 6 h, and SF ratio at 6 h (AUC 0.895). No model was identified for late NIV failure. CONCLUSIONS: SF ratio is a reliable predictor of early NIV failure in children.European Society of Intensive Care MedicineRepositório do Hospital Prof. Doutor Fernando FonsecaMayordomo-Colunga, JPons, MLópez, YSolana, MJRey, CMartı´nez-Camblor, PRodríguez-Núñez, ALópez-Herce, JMedina, AAbadesso, CGarcía-Teresa, MA, et al.2015-01-23T15:54:50Z2013-01-01T00:00:00Z2013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.10/1345engIntensive Care Med. 2013 Jun;39(6):1095-10310.1007/s00134-013-2880-5info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-20T15:52:08Zoai:repositorio.hff.min-saude.pt:10400.10/1345Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:52:26.208675Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio |
title |
Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio |
spellingShingle |
Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio Mayordomo-Colunga, J Noninvasive Ventilation Respiratory insufficiency Child Ventilação não invasiva Insuficiência respiratória Criança |
title_short |
Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio |
title_full |
Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio |
title_fullStr |
Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio |
title_full_unstemmed |
Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio |
title_sort |
Predicting non-invasive ventilation failure in children from the SpO₂/FiO₂ (SF) ratio |
author |
Mayordomo-Colunga, J |
author_facet |
Mayordomo-Colunga, J Pons, M López, Y Solana, MJ Rey, C Martı´nez-Camblor, P Rodríguez-Núñez, A López-Herce, J Medina, A Abadesso, C García-Teresa, MA, et al. |
author_role |
author |
author2 |
Pons, M López, Y Solana, MJ Rey, C Martı´nez-Camblor, P Rodríguez-Núñez, A López-Herce, J Medina, A Abadesso, C García-Teresa, MA, et al. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Hospital Prof. Doutor Fernando Fonseca |
dc.contributor.author.fl_str_mv |
Mayordomo-Colunga, J Pons, M López, Y Solana, MJ Rey, C Martı´nez-Camblor, P Rodríguez-Núñez, A López-Herce, J Medina, A Abadesso, C García-Teresa, MA, et al. |
dc.subject.por.fl_str_mv |
Noninvasive Ventilation Respiratory insufficiency Child Ventilação não invasiva Insuficiência respiratória Criança |
topic |
Noninvasive Ventilation Respiratory insufficiency Child Ventilação não invasiva Insuficiência respiratória Criança |
description |
PURPOSE: Our objective was to assess whether SpO₂/FiO₂ (SF) ratio could be a useful NIV outcome predictor in children with acute respiratory failure (ARF) and tried to develop a predictive model of NIV failure. METHODS: Prospective, observational, multicenter study. Episodes of ARF-fulfilling inclusion criteria from 15 January 2010 to 14 January 2011 were treated with NIV according to a pre-established protocol. Clinical variables were collected at baseline and at 1, 2, 6, 12 and 24 h. Failure criterion was the need for endotracheal intubation. Failures were considered as "early" if occurring ≤6 h after NIV initiation, "intermediate" if occurring between 6 and 24 h, and "late" if occurring after 24 h. Variables with a p < 0.1 in univariate analysis corrected by age were included in multivariate analysis. Models were calculated based on multivariate analysis. RESULTS: During the study period, 390 episodes were included. NIV success rate was 81.3 %. Among ARF causes, failure occurred most frequently in ARDS episodes. The failure predictive model for the whole sample included SF ratio at 1 h, age and PRISM III-24 (area under the curve AUC of 0.755). For early NIV failures, SF ratio at 1 h was the only variable within model (AUC 0.748). The analysis of intermediate NIV failures identified 3 variables independently linked to NIV outcome: PRISM III-24, RR decrease at 6 h, and SF ratio at 6 h (AUC 0.895). No model was identified for late NIV failure. CONCLUSIONS: SF ratio is a reliable predictor of early NIV failure in children. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01T00:00:00Z 2013-01-01T00:00:00Z 2015-01-23T15:54:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.10/1345 |
url |
http://hdl.handle.net/10400.10/1345 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Intensive Care Med. 2013 Jun;39(6):1095-103 10.1007/s00134-013-2880-5 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
European Society of Intensive Care Medicine |
publisher.none.fl_str_mv |
European Society of Intensive Care Medicine |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799130390382772224 |