Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine Polychaeta

Detalhes bibliográficos
Autor(a) principal: D'Ambrosio, Mariaelena
Data de Publicação: 2020
Outros Autores: Santos, Ana Catarina, Alejo-Armijo, Alfonso, Parola, A. Jorge, Costa, Pedro M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/114525
Resumo: PTDC/MAR BIO/01132014 PTDC/BTA-BTA/28650/2017 UID/Multi/04378/2020 UID/QUI/50006/2020 ref. FA_05_2017_007
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spelling Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine PolychaetaannelidaHPLC-DADmarine bioproductsphotosensitizersporphyrinoidstoxicityDrug DiscoverySDG 14 - Life Below WaterPTDC/MAR BIO/01132014 PTDC/BTA-BTA/28650/2017 UID/Multi/04378/2020 UID/QUI/50006/2020 ref. FA_05_2017_007Porphyrins and derivatives form one of the most abundant classes of biochromes. They result from the breakdown of heme and have crucial physiological functions. Bilins are well-known representatives of this group that, besides significant antioxidant and anti-mutagenic properties, are also photosensitizers for photodynamic therapies. Recently, we demonstrated that the Polychaeta Eulalia viridis, common in the Portuguese rocky intertidal, holds a high variety of novel greenish and yellowish porphyrinoid pigments, stored as granules in the chromocytes of several organs. On the follow-up of this study, we chemically characterized pigment extracts from the worm's skin and proboscis using HPLC and evaluated their light and dark toxicity in vivo and ex vivo using Daphnia and mussel gill tissue as models, respectively. The findings showed that the skin and proboscis have distinct patterns of hydrophilic or even amphiphilic porphyrinoids, with some substances in common. The combination of the two bioassays demonstrated that the extracts from the skin exert higher dark toxicity, whereas those from the proboscis rapidly exert light toxicity, then becoming exhausted. One particular yellow pigment that is highly abundant in the proboscis shows highly promising properties as a natural photosensitizer, revealing that porphyrinoids from marine invertebrates are important sources of these high-prized bioproducts.UCIBIO - Applied Molecular Biosciences UnitDCV - Departamento de Ciências da VidaLAQV@REQUIMTEDQ - Departamento de QuímicaRUND'Ambrosio, MariaelenaSantos, Ana CatarinaAlejo-Armijo, AlfonsoParola, A. JorgeCosta, Pedro M.2021-03-26T23:25:28Z2020-06-062020-06-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/114525eng1660-3397PURE: 18781361https://doi.org/10.3390/md18060302info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:57:12Zoai:run.unl.pt:10362/114525Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:42:33.542062Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine Polychaeta
title Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine Polychaeta
spellingShingle Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine Polychaeta
D'Ambrosio, Mariaelena
annelida
HPLC-DAD
marine bioproducts
photosensitizers
porphyrinoids
toxicity
Drug Discovery
SDG 14 - Life Below Water
title_short Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine Polychaeta
title_full Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine Polychaeta
title_fullStr Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine Polychaeta
title_full_unstemmed Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine Polychaeta
title_sort Light-Mediated Toxicity of Porphyrin-Like Pigments from a Marine Polychaeta
author D'Ambrosio, Mariaelena
author_facet D'Ambrosio, Mariaelena
Santos, Ana Catarina
Alejo-Armijo, Alfonso
Parola, A. Jorge
Costa, Pedro M.
author_role author
author2 Santos, Ana Catarina
Alejo-Armijo, Alfonso
Parola, A. Jorge
Costa, Pedro M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DCV - Departamento de Ciências da Vida
LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv D'Ambrosio, Mariaelena
Santos, Ana Catarina
Alejo-Armijo, Alfonso
Parola, A. Jorge
Costa, Pedro M.
dc.subject.por.fl_str_mv annelida
HPLC-DAD
marine bioproducts
photosensitizers
porphyrinoids
toxicity
Drug Discovery
SDG 14 - Life Below Water
topic annelida
HPLC-DAD
marine bioproducts
photosensitizers
porphyrinoids
toxicity
Drug Discovery
SDG 14 - Life Below Water
description PTDC/MAR BIO/01132014 PTDC/BTA-BTA/28650/2017 UID/Multi/04378/2020 UID/QUI/50006/2020 ref. FA_05_2017_007
publishDate 2020
dc.date.none.fl_str_mv 2020-06-06
2020-06-06T00:00:00Z
2021-03-26T23:25:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/114525
url http://hdl.handle.net/10362/114525
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1660-3397
PURE: 18781361
https://doi.org/10.3390/md18060302
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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