Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactants

Detalhes bibliográficos
Autor(a) principal: Fernandes, Ana R.
Data de Publicação: 2021
Outros Autores: Sanchez-Lopez, Elena, Santos, Tiago dos, Garcia, Maria L., Silva, Amelia M., Souto, Eliana Maria Barbosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/75257
Resumo: The eye is a very complex organ comprising several physiological and physical barriers that compromise drug absorption into deeper layers. Nanoemulsions are promising delivery systems to be used in ocular drug delivery due to their innumerous advantages, such as high retention time onto the site of application and the modified release profile of loaded drugs, thereby contributing to increasing the bioavailability of drugs for the treatment of eye diseases, in particular those affecting the posterior segment. In this review, we address the main factors that govern the development of a suitable nanoemulsion formulation for eye administration to increase the patient’s compliance to the treatment. Appropriate lipid composition and type of surfactants (with a special emphasis on cationic compounds) are discussed, together with manufacturing techniques and characterization methods that are instrumental for the development of appropriate ophthalmic nanoemulsions.
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spelling Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactantsNanoemulsionsOcular barriersOcular deliveryCationic surfactantsScience & TechnologyThe eye is a very complex organ comprising several physiological and physical barriers that compromise drug absorption into deeper layers. Nanoemulsions are promising delivery systems to be used in ocular drug delivery due to their innumerous advantages, such as high retention time onto the site of application and the modified release profile of loaded drugs, thereby contributing to increasing the bioavailability of drugs for the treatment of eye diseases, in particular those affecting the posterior segment. In this review, we address the main factors that govern the development of a suitable nanoemulsion formulation for eye administration to increase the patient’s compliance to the treatment. Appropriate lipid composition and type of surfactants (with a special emphasis on cationic compounds) are discussed, together with manufacturing techniques and characterization methods that are instrumental for the development of appropriate ophthalmic nanoemulsions.This work was funded by the Portuguese Science and Technology Foundation (FCT) from the Ministry of Science and Technology (MCTES), European Social Fund (FSE) of the EU, for the scholarship SFRH/BD/130555/2017 granted to A. R. Fernandes, and for the projects UIDB/04469/2020 (CEB strategic fund) and UIDB/04033/2020 (CITAB), co-funded by European Funds (PRODER/COMPETE) and FEDER, under the Partnership Agreement PT2020.info:eu-repo/semantics/publishedVersionMDPI PublishingUniversidade do MinhoFernandes, Ana R.Sanchez-Lopez, ElenaSantos, Tiago dosGarcia, Maria L.Silva, Amelia M.Souto, Eliana Maria Barbosa2021-12-082021-12-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/75257engFernandes, Ana R.; Sanchez-Lopez, Elena; Santos, Tiago dos; Garcia, Maria L.; Silva, Amelia M.; Souto, Eliana B., Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactants. Materials, 14(24), 7541, 20211996-194410.3390/ma14247541http://www.mdpi.com/journal/materialsinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:27Zoai:repositorium.sdum.uminho.pt:1822/75257Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:32.235483Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactants
title Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactants
spellingShingle Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactants
Fernandes, Ana R.
Nanoemulsions
Ocular barriers
Ocular delivery
Cationic surfactants
Science & Technology
title_short Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactants
title_full Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactants
title_fullStr Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactants
title_full_unstemmed Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactants
title_sort Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactants
author Fernandes, Ana R.
author_facet Fernandes, Ana R.
Sanchez-Lopez, Elena
Santos, Tiago dos
Garcia, Maria L.
Silva, Amelia M.
Souto, Eliana Maria Barbosa
author_role author
author2 Sanchez-Lopez, Elena
Santos, Tiago dos
Garcia, Maria L.
Silva, Amelia M.
Souto, Eliana Maria Barbosa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Fernandes, Ana R.
Sanchez-Lopez, Elena
Santos, Tiago dos
Garcia, Maria L.
Silva, Amelia M.
Souto, Eliana Maria Barbosa
dc.subject.por.fl_str_mv Nanoemulsions
Ocular barriers
Ocular delivery
Cationic surfactants
Science & Technology
topic Nanoemulsions
Ocular barriers
Ocular delivery
Cationic surfactants
Science & Technology
description The eye is a very complex organ comprising several physiological and physical barriers that compromise drug absorption into deeper layers. Nanoemulsions are promising delivery systems to be used in ocular drug delivery due to their innumerous advantages, such as high retention time onto the site of application and the modified release profile of loaded drugs, thereby contributing to increasing the bioavailability of drugs for the treatment of eye diseases, in particular those affecting the posterior segment. In this review, we address the main factors that govern the development of a suitable nanoemulsion formulation for eye administration to increase the patient’s compliance to the treatment. Appropriate lipid composition and type of surfactants (with a special emphasis on cationic compounds) are discussed, together with manufacturing techniques and characterization methods that are instrumental for the development of appropriate ophthalmic nanoemulsions.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-08
2021-12-08T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/75257
url https://hdl.handle.net/1822/75257
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Fernandes, Ana R.; Sanchez-Lopez, Elena; Santos, Tiago dos; Garcia, Maria L.; Silva, Amelia M.; Souto, Eliana B., Development and characterization of nanoemulsions for ophthalmic applications: role of cationic surfactants. Materials, 14(24), 7541, 2021
1996-1944
10.3390/ma14247541
http://www.mdpi.com/journal/materials
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI Publishing
publisher.none.fl_str_mv MDPI Publishing
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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