Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease

Detalhes bibliográficos
Autor(a) principal: Pereira, A.
Data de Publicação: 2016
Outros Autores: Reis, Roberto Palma dos, Rodrigues, R., Sousa, A. C., Gomes, S., Borges, S., Ornelas, I., Freitas, A. I., Guerra, G., Henriques, E., Rodrigues, M., Freitas, S., Freitas, C., Brehm, A., Pereira, D., Mendonça, M. I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/147881
Resumo: Funding: This study was supported by the European Regional Development Fund’s Operational Programme for the Enhancement of Economic Potential and Territorial Cohesion for the Autonomous Region of Madeira (INTERVIR ).
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spelling Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery diseaseADAMTS7 geneCardiovascular survivalCoronary artery diseaseSingle nucleotide polymorphism (SNP)PhysiologyGeneticsFunding: This study was supported by the European Regional Development Fund’s Operational Programme for the Enhancement of Economic Potential and Territorial Cohesion for the Autonomous Region of Madeira (INTERVIR ).Recent genetic studies have revealed an association between polymorphisms at the ADAMTS7 gene locus and coronary artery disease (CAD) risk. Functional studies have shown that a CAD-associated polymorphism (rs3825807) affects ADAMTS7 maturation and vascular smooth muscular cell (VSMC) migration. Here, we tested whether ADAMTS7 (A/G) SNP is associated with cardiovascular (CV) survival in patients with established CAD. A cohort of 1,128 patients with angiographic proven CAD, who were followed up prospectively for a mean follow- up period of 63 (range 6-182) mo, were genotyped for rs3825807 A/G. Survival statistics (Cox regression) compared heterozygous (AG) and wild-type (AA) with the reference homozygous GG. Kaplan- Meier (K-M) survival curves were performed according to ADAMTS7 genotypes for CV mortality. Results showed that 47.3% of patients were heterozygous (AG), 36.5% were homozygous for the wild-type allele (AA) and only 16.2% were homozygous for the GG genotype. During the follow-up period, 109 (9.7%) patients died, 77 (6.8%) of CV causes. Survival analysis showed that AA genotype was an independent risk factor for CV mortality compared with reference genotype GG (HR = 2.7, P = 0.025). At the end of follow-up, the estimated survival probability (K-M) was 89.8% for GG genotype, 82.2% for AG and 72.3% for AA genotype (P = 0.039). Carriage of the mutant G allele of the ADAMTS7 gene was associated with improved CV survival in patients with documented CAD. The native overfunctional ADAMTS7 allele (A) may accelerate VSMC migration and lead to neointimal thickening, atherosclerosis progression and acute plaque events. ADAMTS7 gene should be further explored in CAD for risk prediction, mechanistic and therapeutic goals.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNPereira, A.Reis, Roberto Palma dosRodrigues, R.Sousa, A. C.Gomes, S.Borges, S.Ornelas, I.Freitas, A. I.Guerra, G.Henriques, E.Rodrigues, M.Freitas, S.Freitas, C.Brehm, A.Pereira, D.Mendonça, M. I.2023-01-20T22:09:10Z2016-11-012016-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://hdl.handle.net/10362/147881eng1094-8341PURE: 2199166https://doi.org/10.1152/physiolgenomics.00059.2016info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:29:10Zoai:run.unl.pt:10362/147881Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:07.466172Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease
title Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease
spellingShingle Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease
Pereira, A.
ADAMTS7 gene
Cardiovascular survival
Coronary artery disease
Single nucleotide polymorphism (SNP)
Physiology
Genetics
title_short Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease
title_full Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease
title_fullStr Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease
title_full_unstemmed Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease
title_sort Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease
author Pereira, A.
author_facet Pereira, A.
Reis, Roberto Palma dos
Rodrigues, R.
Sousa, A. C.
Gomes, S.
Borges, S.
Ornelas, I.
Freitas, A. I.
Guerra, G.
Henriques, E.
Rodrigues, M.
Freitas, S.
Freitas, C.
Brehm, A.
Pereira, D.
Mendonça, M. I.
author_role author
author2 Reis, Roberto Palma dos
Rodrigues, R.
Sousa, A. C.
Gomes, S.
Borges, S.
Ornelas, I.
Freitas, A. I.
Guerra, G.
Henriques, E.
Rodrigues, M.
Freitas, S.
Freitas, C.
Brehm, A.
Pereira, D.
Mendonça, M. I.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Pereira, A.
Reis, Roberto Palma dos
Rodrigues, R.
Sousa, A. C.
Gomes, S.
Borges, S.
Ornelas, I.
Freitas, A. I.
Guerra, G.
Henriques, E.
Rodrigues, M.
Freitas, S.
Freitas, C.
Brehm, A.
Pereira, D.
Mendonça, M. I.
dc.subject.por.fl_str_mv ADAMTS7 gene
Cardiovascular survival
Coronary artery disease
Single nucleotide polymorphism (SNP)
Physiology
Genetics
topic ADAMTS7 gene
Cardiovascular survival
Coronary artery disease
Single nucleotide polymorphism (SNP)
Physiology
Genetics
description Funding: This study was supported by the European Regional Development Fund’s Operational Programme for the Enhancement of Economic Potential and Territorial Cohesion for the Autonomous Region of Madeira (INTERVIR ).
publishDate 2016
dc.date.none.fl_str_mv 2016-11-01
2016-11-01T00:00:00Z
2023-01-20T22:09:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/147881
url http://hdl.handle.net/10362/147881
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1094-8341
PURE: 2199166
https://doi.org/10.1152/physiolgenomics.00059.2016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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