Paediatric visceral leishmaniasis: experience of a paediatric referral center 1990-2009.
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/466 |
Resumo: | Visceral Leishmaniasis (VL) is a systemic infection, endemic in many parts of the world, including Portugal. The aim is to review all cases of VL admitted to our hospital.Retrospective analysis of all cases of VL admitted to a Level III Paediatric Hospital, between January 1990 and December 2009 (20 years). Demographic, epidemiological, clinical, laboratorial, therapeutic and follow-up data were analysed.During the study period, 54 children were admitted with VL, three of which were excluded from the study due to incomplete clinical records. The mean age was 27 months (seven months - twelve years) and 53% were female. Two thirds of the cases were diagnosed during Spring and Summer. The mean time for diagnosis was 31 days (2-188 days). The most common clinical findings were splenomegaly (100%), fever (96%), pallor (90%) and hepatomegaly (82%). Bone marrow aspiration was performed in all children, with amastigotes identified in 73% of the cases. Indirect immunofluorescence was performed in 30 cases, being positive in 29 (97%). All were treated with meglumine antimoniate. Three children relapsed during the first year after the initial episode. A 17 months-old child died due to cardiac failure.The early diagnosis of VL is essential to carry out prompt management and prevent potential fatal complications. In our analysis, the management with meglumine antimoniate resulted in an overall favourable outcome. |
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Paediatric visceral leishmaniasis: experience of a paediatric referral center 1990-2009.Leishmaniose visceral: experiência de um centro pediátrico de referência 1990-2009.Visceral Leishmaniasis (VL) is a systemic infection, endemic in many parts of the world, including Portugal. The aim is to review all cases of VL admitted to our hospital.Retrospective analysis of all cases of VL admitted to a Level III Paediatric Hospital, between January 1990 and December 2009 (20 years). Demographic, epidemiological, clinical, laboratorial, therapeutic and follow-up data were analysed.During the study period, 54 children were admitted with VL, three of which were excluded from the study due to incomplete clinical records. The mean age was 27 months (seven months - twelve years) and 53% were female. Two thirds of the cases were diagnosed during Spring and Summer. The mean time for diagnosis was 31 days (2-188 days). The most common clinical findings were splenomegaly (100%), fever (96%), pallor (90%) and hepatomegaly (82%). Bone marrow aspiration was performed in all children, with amastigotes identified in 73% of the cases. Indirect immunofluorescence was performed in 30 cases, being positive in 29 (97%). All were treated with meglumine antimoniate. Three children relapsed during the first year after the initial episode. A 17 months-old child died due to cardiac failure.The early diagnosis of VL is essential to carry out prompt management and prevent potential fatal complications. In our analysis, the management with meglumine antimoniate resulted in an overall favourable outcome.Visceral Leishmaniasis (VL) is a systemic infection, endemic in many parts of the world, including Portugal. The aim is to review all cases of VL admitted to our hospital.Retrospective analysis of all cases of VL admitted to a Level III Paediatric Hospital, between January 1990 and December 2009 (20 years). Demographic, epidemiological, clinical, laboratorial, therapeutic and follow-up data were analysed.During the study period, 54 children were admitted with VL, three of which were excluded from the study due to incomplete clinical records. The mean age was 27 months (seven months - twelve years) and 53% were female. Two thirds of the cases were diagnosed during Spring and Summer. The mean time for diagnosis was 31 days (2-188 days). The most common clinical findings were splenomegaly (100%), fever (96%), pallor (90%) and hepatomegaly (82%). Bone marrow aspiration was performed in all children, with amastigotes identified in 73% of the cases. Indirect immunofluorescence was performed in 30 cases, being positive in 29 (97%). All were treated with meglumine antimoniate. Three children relapsed during the first year after the initial episode. A 17 months-old child died due to cardiac failure.The early diagnosis of VL is essential to carry out prompt management and prevent potential fatal complications. In our analysis, the management with meglumine antimoniate resulted in an overall favourable outcome.Ordem dos Médicos2011-08-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/466oai:ojs.www.actamedicaportuguesa.com:article/466Acta Médica Portuguesa; Vol. 24 No. 3 (2011): Maio-Junho; 399-404Acta Médica Portuguesa; Vol. 24 N.º 3 (2011): Maio-Junho; 399-4041646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/466https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/466/174Dionísio, Maria TeresaDias, AndreaRodrigues, FernandaFélix, MiguelEstêvão, Maria Helenainfo:eu-repo/semantics/openAccess2022-12-20T10:56:16Zoai:ojs.www.actamedicaportuguesa.com:article/466Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:16:30.648943Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Paediatric visceral leishmaniasis: experience of a paediatric referral center 1990-2009. Leishmaniose visceral: experiência de um centro pediátrico de referência 1990-2009. |
title |
Paediatric visceral leishmaniasis: experience of a paediatric referral center 1990-2009. |
spellingShingle |
Paediatric visceral leishmaniasis: experience of a paediatric referral center 1990-2009. Dionísio, Maria Teresa |
title_short |
Paediatric visceral leishmaniasis: experience of a paediatric referral center 1990-2009. |
title_full |
Paediatric visceral leishmaniasis: experience of a paediatric referral center 1990-2009. |
title_fullStr |
Paediatric visceral leishmaniasis: experience of a paediatric referral center 1990-2009. |
title_full_unstemmed |
Paediatric visceral leishmaniasis: experience of a paediatric referral center 1990-2009. |
title_sort |
Paediatric visceral leishmaniasis: experience of a paediatric referral center 1990-2009. |
author |
Dionísio, Maria Teresa |
author_facet |
Dionísio, Maria Teresa Dias, Andrea Rodrigues, Fernanda Félix, Miguel Estêvão, Maria Helena |
author_role |
author |
author2 |
Dias, Andrea Rodrigues, Fernanda Félix, Miguel Estêvão, Maria Helena |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Dionísio, Maria Teresa Dias, Andrea Rodrigues, Fernanda Félix, Miguel Estêvão, Maria Helena |
description |
Visceral Leishmaniasis (VL) is a systemic infection, endemic in many parts of the world, including Portugal. The aim is to review all cases of VL admitted to our hospital.Retrospective analysis of all cases of VL admitted to a Level III Paediatric Hospital, between January 1990 and December 2009 (20 years). Demographic, epidemiological, clinical, laboratorial, therapeutic and follow-up data were analysed.During the study period, 54 children were admitted with VL, three of which were excluded from the study due to incomplete clinical records. The mean age was 27 months (seven months - twelve years) and 53% were female. Two thirds of the cases were diagnosed during Spring and Summer. The mean time for diagnosis was 31 days (2-188 days). The most common clinical findings were splenomegaly (100%), fever (96%), pallor (90%) and hepatomegaly (82%). Bone marrow aspiration was performed in all children, with amastigotes identified in 73% of the cases. Indirect immunofluorescence was performed in 30 cases, being positive in 29 (97%). All were treated with meglumine antimoniate. Three children relapsed during the first year after the initial episode. A 17 months-old child died due to cardiac failure.The early diagnosis of VL is essential to carry out prompt management and prevent potential fatal complications. In our analysis, the management with meglumine antimoniate resulted in an overall favourable outcome. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-08-12 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/466 oai:ojs.www.actamedicaportuguesa.com:article/466 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/466 |
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oai:ojs.www.actamedicaportuguesa.com:article/466 |
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por |
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por |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/466 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/466/174 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 24 No. 3 (2011): Maio-Junho; 399-404 Acta Médica Portuguesa; Vol. 24 N.º 3 (2011): Maio-Junho; 399-404 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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