Predictors of cardiac involvement in idiopathic inflammatory myopathies
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/58066 |
Resumo: | Copyright © 2023 Bandeira, Dourado, Melo, Martins, Fraga, Ferraro, Saraiva, Sousa, Parente, Soares, Correia, Almeida, Dinis, Pinto, Oliveira Pinheiro, Rato, Beirão, Samões, Santos, Mazeda, Chícharo, Faria, Neto, Lourenço, Brites, Rodrigues, Silva-Dinis, Dias, Araújo, Martins, Couto, Valido, Santos, Barreira, Fonseca and Campanilho-Marques. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Predictors of cardiac involvement in idiopathic inflammatory myopathiesBiomarkersCardiac involvementIdiopathic inflammatory myopathiesMyocarditisPredictorsRisk factorsCopyright © 2023 Bandeira, Dourado, Melo, Martins, Fraga, Ferraro, Saraiva, Sousa, Parente, Soares, Correia, Almeida, Dinis, Pinto, Oliveira Pinheiro, Rato, Beirão, Samões, Santos, Mazeda, Chícharo, Faria, Neto, Lourenço, Brites, Rodrigues, Silva-Dinis, Dias, Araújo, Martins, Couto, Valido, Santos, Barreira, Fonseca and Campanilho-Marques. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Objectives: Idiopathic inflammatory myopathies (IIM) are a group of rare disorders that can affect the heart. This work aimed to find predictors of cardiac involvement in IIM. Methods: Multicenter, open cohort study, including patients registered in the IIM module of the Rheumatic Diseases Portuguese Register (Reuma.pt/Myositis) until January 2022. Patients without cardiac involvement information were excluded. Myo(peri)carditis, dilated cardiomyopathy, conduction abnormalities, and/or premature coronary artery disease were considered. Results: 230 patients were included, 163 (70.9%) of whom were females. Thirteen patients (5.7%) had cardiac involvement. Compared with IIM patients without cardiac involvement, these patients had a lower bilateral manual muscle testing score (MMT) at the peak of muscle weakness [108.0 ± 55.0 vs 147.5 ± 22.0, p=0.008] and more frequently had oesophageal [6/12 (50.0%) vs 33/207 (15.9%), p=0.009] and lung [10/13 (76.9%) vs 68/216 (31.5%), p=0.001] involvements. Anti-SRP antibodies were more commonly identified in patients with cardiac involvement [3/11 (27.3%) vs 9/174 (5.2%), p=0.026]. In the multivariate analysis, positivity for anti-SRP antibodies (OR 104.3, 95% CI: 2.5-4277.8, p=0.014) was a predictor of cardiac involvement, regardless of sex, ethnicity, age at diagnosis, and lung involvement. Sensitivity analysis confirmed these results. Conclusion: Anti-SRP antibodies were predictors of cardiac involvement in our cohort of IIM patients, irrespective of demographical characteristics and lung involvement. We suggest considering frequent screening for heart involvement in anti-SRP-positive IIM patients.FrontiersRepositório da Universidade de LisboaBandeira, MatildeDourado, EduardoMelo, Ana TeresaMartins, PatríciaFraga, VanessaFerraro, José LuísSaraiva, AndréSousa, MarleneParente, HugoSoares, CatarinaCorreia, Ana MargaridaAlmeida, Diogo EsperançaDinis, Sara PaivaPinto, Ana SofiaOliveira Pinheiro, FilipeRato, Maria SeabraBeirão, TiagoSamões, BeatrizSantos, BernardoMazeda, CarolinaChícharo, Ana TeodósioFaria, MargaridaNeto, AgnaLourenço, Maria HelenaBrites, LuísaRodrigues, MaríliaSilva-Dinis, JoanaDias, João MadrugaAraújo, Filipe C.Martins, NádiaCouto, MauraValido, AnaSantos, MariaBarreira, SofiaFonseca, João EuricoCampanilho-Marques, Raquel2023-06-07T14:06:04Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/58066engFront Immunol. 2023 Mar 8;14:114681710.3389/fimmu.2023.11468171664-3224info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:06:39Zoai:repositorio.ul.pt:10451/58066Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:08:19.697074Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Predictors of cardiac involvement in idiopathic inflammatory myopathies |
| title |
Predictors of cardiac involvement in idiopathic inflammatory myopathies |
| spellingShingle |
Predictors of cardiac involvement in idiopathic inflammatory myopathies Bandeira, Matilde Biomarkers Cardiac involvement Idiopathic inflammatory myopathies Myocarditis Predictors Risk factors |
| title_short |
Predictors of cardiac involvement in idiopathic inflammatory myopathies |
| title_full |
Predictors of cardiac involvement in idiopathic inflammatory myopathies |
| title_fullStr |
Predictors of cardiac involvement in idiopathic inflammatory myopathies |
| title_full_unstemmed |
Predictors of cardiac involvement in idiopathic inflammatory myopathies |
| title_sort |
Predictors of cardiac involvement in idiopathic inflammatory myopathies |
| author |
Bandeira, Matilde |
| author_facet |
Bandeira, Matilde Dourado, Eduardo Melo, Ana Teresa Martins, Patrícia Fraga, Vanessa Ferraro, José Luís Saraiva, André Sousa, Marlene Parente, Hugo Soares, Catarina Correia, Ana Margarida Almeida, Diogo Esperança Dinis, Sara Paiva Pinto, Ana Sofia Oliveira Pinheiro, Filipe Rato, Maria Seabra Beirão, Tiago Samões, Beatriz Santos, Bernardo Mazeda, Carolina Chícharo, Ana Teodósio Faria, Margarida Neto, Agna Lourenço, Maria Helena Brites, Luísa Rodrigues, Marília Silva-Dinis, Joana Dias, João Madruga Araújo, Filipe C. Martins, Nádia Couto, Maura Valido, Ana Santos, Maria Barreira, Sofia Fonseca, João Eurico Campanilho-Marques, Raquel |
| author_role |
author |
| author2 |
Dourado, Eduardo Melo, Ana Teresa Martins, Patrícia Fraga, Vanessa Ferraro, José Luís Saraiva, André Sousa, Marlene Parente, Hugo Soares, Catarina Correia, Ana Margarida Almeida, Diogo Esperança Dinis, Sara Paiva Pinto, Ana Sofia Oliveira Pinheiro, Filipe Rato, Maria Seabra Beirão, Tiago Samões, Beatriz Santos, Bernardo Mazeda, Carolina Chícharo, Ana Teodósio Faria, Margarida Neto, Agna Lourenço, Maria Helena Brites, Luísa Rodrigues, Marília Silva-Dinis, Joana Dias, João Madruga Araújo, Filipe C. Martins, Nádia Couto, Maura Valido, Ana Santos, Maria Barreira, Sofia Fonseca, João Eurico Campanilho-Marques, Raquel |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Bandeira, Matilde Dourado, Eduardo Melo, Ana Teresa Martins, Patrícia Fraga, Vanessa Ferraro, José Luís Saraiva, André Sousa, Marlene Parente, Hugo Soares, Catarina Correia, Ana Margarida Almeida, Diogo Esperança Dinis, Sara Paiva Pinto, Ana Sofia Oliveira Pinheiro, Filipe Rato, Maria Seabra Beirão, Tiago Samões, Beatriz Santos, Bernardo Mazeda, Carolina Chícharo, Ana Teodósio Faria, Margarida Neto, Agna Lourenço, Maria Helena Brites, Luísa Rodrigues, Marília Silva-Dinis, Joana Dias, João Madruga Araújo, Filipe C. Martins, Nádia Couto, Maura Valido, Ana Santos, Maria Barreira, Sofia Fonseca, João Eurico Campanilho-Marques, Raquel |
| dc.subject.por.fl_str_mv |
Biomarkers Cardiac involvement Idiopathic inflammatory myopathies Myocarditis Predictors Risk factors |
| topic |
Biomarkers Cardiac involvement Idiopathic inflammatory myopathies Myocarditis Predictors Risk factors |
| description |
Copyright © 2023 Bandeira, Dourado, Melo, Martins, Fraga, Ferraro, Saraiva, Sousa, Parente, Soares, Correia, Almeida, Dinis, Pinto, Oliveira Pinheiro, Rato, Beirão, Samões, Santos, Mazeda, Chícharo, Faria, Neto, Lourenço, Brites, Rodrigues, Silva-Dinis, Dias, Araújo, Martins, Couto, Valido, Santos, Barreira, Fonseca and Campanilho-Marques. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| publishDate |
2023 |
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2023-06-07T14:06:04Z 2023 2023-01-01T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/58066 |
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http://hdl.handle.net/10451/58066 |
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eng |
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eng |
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Front Immunol. 2023 Mar 8;14:1146817 10.3389/fimmu.2023.1146817 1664-3224 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Frontiers |
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Frontiers |
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