SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.7/593 |
Resumo: | This deposit is composed by the main article plus the supplementary materials of the publication. |
| id |
RCAP_19eecb5d7d958ec81f52e2943c786cf6 |
|---|---|
| oai_identifier_str |
oai:arca.igc.gulbenkian.pt:10400.7/593 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast BrazilMycobacterium tuberculois complexPortugalBrazilSNP typingSpoligotypingPhylogenyThis deposit is composed by the main article plus the supplementary materials of the publication.Human tuberculosis is an infectious disease caused by bacteria from the Mycobacterium tuberculosis complex (MTBC). Although spoligotyping and MIRU-VNTR are standard methodologies in MTBC genetic epidemiology, recent studies suggest that Single Nucleotide Polymorphisms (SNP) are advantageous in phylogenetics and strain group/lineages identification. In this work we use a set of 79 SNPs to characterize 1987 MTBC isolates from Portugal and 141 from Northeast Brazil. All Brazilian samples were further characterized using spolygotyping. Phylogenetic analysis against a reference set revealed that about 95% of the isolates in both populations are singly attributed to bacterial lineage 4. Within this lineage, the most frequent strain groups in both Portugal and Brazil are LAM, followed by Haarlem and X. Contrary to these groups, strain group T showed a very different prevalence between Portugal (10%) and Brazil (1.5%). Spoligotype identification shows about 10% of mis-matches compared to the use of SNPs and a little more than 1% of strains unidentifiability. The mis-matches are observed in the most represented groups of our sample set (i.e., LAM and Haarlem) in almost the same proportion. Besides being more accurate in identifying strain groups/lineages, SNP-typing can also provide phylogenetic relationships between strain groups/lineages and, thus, indicate cases showing phylogenetic incongruence. Overall, the use of SNP-typing revealed striking similarities between MTBC populations from Portugal and Brazil.FCT; National Counsel of Technological and Scientific Development (CNPQ) project number: (410498/2006-8); Coordination of Improvement of Higher Education Personnel (CAPES) project number: (23038.005107/2011-83).Elsivier Science BVARCAMarques, IsabelSoares, PatriciaNebenzahl-Guimaraes, HannaCosta, JoaoMiranda, AnabelaDuarte, RaquelAlves, AdrianaMacedo, RitaDuarte, Tonya A.Barbosa, TheolisOliveira, MarthaNery, Joilda S.Boechat, NeioPereira, Susan M.Barreto, Mauricio L.Pereira-Leal, JoseGomes, Maria Gabriela MirandaPenha-Goncalves, Carlos2017-05-03T00:30:09Z2013-05-032013-05-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10400.7/593engLopes, J. S., Marques, I., Soares, P., Nebenzahl-Guimaraes, H., Costa, J., Miranda, A., Duarte, R., Alves, A., Macedo, R., Duarte, T. A., Barbosa, T., Oliveira, M., Nery, J. S., Boechat, N., Pereira, S. M., Barreto, M. L., Pereira-Leal, J., Gomes, M. G. M., Penha-Goncalves, C. (2013). SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil. Infect. Genet. Evol., 18, 238–246.10.1016/j.meegid.2013.04.028info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:34:58Zoai:arca.igc.gulbenkian.pt:10400.7/593Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:50.430556Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil |
| title |
SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil |
| spellingShingle |
SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil Marques, Isabel Mycobacterium tuberculois complex Portugal Brazil SNP typing Spoligotyping Phylogeny |
| title_short |
SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil |
| title_full |
SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil |
| title_fullStr |
SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil |
| title_full_unstemmed |
SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil |
| title_sort |
SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil |
| author |
Marques, Isabel |
| author_facet |
Marques, Isabel Soares, Patricia Nebenzahl-Guimaraes, Hanna Costa, Joao Miranda, Anabela Duarte, Raquel Alves, Adriana Macedo, Rita Duarte, Tonya A. Barbosa, Theolis Oliveira, Martha Nery, Joilda S. Boechat, Neio Pereira, Susan M. Barreto, Mauricio L. Pereira-Leal, Jose Gomes, Maria Gabriela Miranda Penha-Goncalves, Carlos |
| author_role |
author |
| author2 |
Soares, Patricia Nebenzahl-Guimaraes, Hanna Costa, Joao Miranda, Anabela Duarte, Raquel Alves, Adriana Macedo, Rita Duarte, Tonya A. Barbosa, Theolis Oliveira, Martha Nery, Joilda S. Boechat, Neio Pereira, Susan M. Barreto, Mauricio L. Pereira-Leal, Jose Gomes, Maria Gabriela Miranda Penha-Goncalves, Carlos |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
ARCA |
| dc.contributor.author.fl_str_mv |
Marques, Isabel Soares, Patricia Nebenzahl-Guimaraes, Hanna Costa, Joao Miranda, Anabela Duarte, Raquel Alves, Adriana Macedo, Rita Duarte, Tonya A. Barbosa, Theolis Oliveira, Martha Nery, Joilda S. Boechat, Neio Pereira, Susan M. Barreto, Mauricio L. Pereira-Leal, Jose Gomes, Maria Gabriela Miranda Penha-Goncalves, Carlos |
| dc.subject.por.fl_str_mv |
Mycobacterium tuberculois complex Portugal Brazil SNP typing Spoligotyping Phylogeny |
| topic |
Mycobacterium tuberculois complex Portugal Brazil SNP typing Spoligotyping Phylogeny |
| description |
This deposit is composed by the main article plus the supplementary materials of the publication. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013-05-03 2013-05-03T00:00:00Z 2017-05-03T00:30:09Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.7/593 |
| url |
http://hdl.handle.net/10400.7/593 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Lopes, J. S., Marques, I., Soares, P., Nebenzahl-Guimaraes, H., Costa, J., Miranda, A., Duarte, R., Alves, A., Macedo, R., Duarte, T. A., Barbosa, T., Oliveira, M., Nery, J. S., Boechat, N., Pereira, S. M., Barreto, M. L., Pereira-Leal, J., Gomes, M. G. M., Penha-Goncalves, C. (2013). SNP typing reveals similarity in Mycobacterium tuberculosis genetic diversity between Portugal and Northeast Brazil. Infect. Genet. Evol., 18, 238–246. 10.1016/j.meegid.2013.04.028 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Elsivier Science BV |
| publisher.none.fl_str_mv |
Elsivier Science BV |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799130573749354496 |