Lipid nanocarriers for hyperproliferative skin diseases

Detalhes bibliográficos
Autor(a) principal: Souto, Eliana B.
Data de Publicação: 2021
Outros Autores: Souza, Ana L. R. de, Santos, Fernanda K. dos, Sanchez-Lopez, Elena, Cano, Amanda, Zielinska, Aleksandra, Staszewski, Rafal, Karczewski, Jacek, Gremião, Maria P. D., Chorilli, Marlus
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/74717
Resumo: Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD.
id RCAP_1a3c045ae8750e0c196cda3aa9962ecb
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/74717
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Lipid nanocarriers for hyperproliferative skin diseasesLipid nanoparticlesLiposomesHyperproliferative skin diseasesAntiproliferative drugsSkin cancerScience & TechnologyHyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD.This research was funded by the Portuguese Science and Technology Foundation (FCT/MCT), European Funds (PRODER/COMPETE)—project UIDB/04469/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020. The work is also supported by the National Science Centre within the MINIATURA 4 for a single research activity (grant no: 2020/04/X/ST5/00789) and by the START 2021 Program of the Foundation for Polish Science (FNP) granted to Aleksandra Zielínskainfo:eu-repo/semantics/publishedVersionMultidisciplinary Digital Publishing Institute (MDPI)Universidade do MinhoSouto, Eliana B.Souza, Ana L. R. deSantos, Fernanda K. dosSanchez-Lopez, ElenaCano, AmandaZielinska, AleksandraStaszewski, RafalKarczewski, JacekGremião, Maria P. D.Chorilli, Marlus2021-11-102021-11-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/74717engSouto, Eliana; de Souza, Ana L. R.; Santos, Fernanda K. dos; Sanchez-Lopez, Elena; Cano, Amanda; Zielinska, Aleksandra; Staszewski, Rafal; Karczewski, Jacek; Gremião, Maria P. D.; Chorilli, Marlus, Lipid nanocarriers for hyperproliferative skin diseases. Cancers, 13(22), 5619, 20212072-669410.3390/cancers13225619https://www.mdpi.com/2072-6694/13/22/5619info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:09:44Zoai:repositorium.sdum.uminho.pt:1822/74717Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:01:13.590817Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Lipid nanocarriers for hyperproliferative skin diseases
title Lipid nanocarriers for hyperproliferative skin diseases
spellingShingle Lipid nanocarriers for hyperproliferative skin diseases
Souto, Eliana B.
Lipid nanoparticles
Liposomes
Hyperproliferative skin diseases
Antiproliferative drugs
Skin cancer
Science & Technology
title_short Lipid nanocarriers for hyperproliferative skin diseases
title_full Lipid nanocarriers for hyperproliferative skin diseases
title_fullStr Lipid nanocarriers for hyperproliferative skin diseases
title_full_unstemmed Lipid nanocarriers for hyperproliferative skin diseases
title_sort Lipid nanocarriers for hyperproliferative skin diseases
author Souto, Eliana B.
author_facet Souto, Eliana B.
Souza, Ana L. R. de
Santos, Fernanda K. dos
Sanchez-Lopez, Elena
Cano, Amanda
Zielinska, Aleksandra
Staszewski, Rafal
Karczewski, Jacek
Gremião, Maria P. D.
Chorilli, Marlus
author_role author
author2 Souza, Ana L. R. de
Santos, Fernanda K. dos
Sanchez-Lopez, Elena
Cano, Amanda
Zielinska, Aleksandra
Staszewski, Rafal
Karczewski, Jacek
Gremião, Maria P. D.
Chorilli, Marlus
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Souto, Eliana B.
Souza, Ana L. R. de
Santos, Fernanda K. dos
Sanchez-Lopez, Elena
Cano, Amanda
Zielinska, Aleksandra
Staszewski, Rafal
Karczewski, Jacek
Gremião, Maria P. D.
Chorilli, Marlus
dc.subject.por.fl_str_mv Lipid nanoparticles
Liposomes
Hyperproliferative skin diseases
Antiproliferative drugs
Skin cancer
Science & Technology
topic Lipid nanoparticles
Liposomes
Hyperproliferative skin diseases
Antiproliferative drugs
Skin cancer
Science & Technology
description Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-10
2021-11-10T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/74717
url http://hdl.handle.net/1822/74717
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Souto, Eliana; de Souza, Ana L. R.; Santos, Fernanda K. dos; Sanchez-Lopez, Elena; Cano, Amanda; Zielinska, Aleksandra; Staszewski, Rafal; Karczewski, Jacek; Gremião, Maria P. D.; Chorilli, Marlus, Lipid nanocarriers for hyperproliferative skin diseases. Cancers, 13(22), 5619, 2021
2072-6694
10.3390/cancers13225619
https://www.mdpi.com/2072-6694/13/22/5619
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132410564050944

Registros relacionados