Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis

Detalhes bibliográficos
Autor(a) principal: Weber, Juliana Inês
Data de Publicação: 2023
Outros Autores: Rodrigues, Armanda Viana, Valério-Bolas, Ana, Nunes, Telmo, Carvalheiro, Manuela, Antunes, Wilson, Alexandre-Pires, Graça, da Fonseca, Isabel Pereira, Santos-Gomes, Gabriela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/155416
Resumo: Funding Information: This study was supported by FCT-Foundation for Science and Technology, I.P., through research grant PTDC/CVT-CVT/28908/2017 and PTDC/CVT-CVT/0228/2020 and by national funds within the scope of Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020) and Global Health and Tropical Medicine (GHTM, UID/04413/2020). Publisher Copyright: © 2023 by the authors.
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spelling Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensisextracellular vesiclesimmunomodulationLeishmania guyanensisLeishmania shawileishmaniasismacrophagesQR180 ImmunologyQR MicrobiologyBiochemistry, Genetics and Molecular Biology(all)ParasitologyImmunologySDG 3 - Good Health and Well-beingFunding Information: This study was supported by FCT-Foundation for Science and Technology, I.P., through research grant PTDC/CVT-CVT/28908/2017 and PTDC/CVT-CVT/0228/2020 and by national funds within the scope of Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020) and Global Health and Tropical Medicine (GHTM, UID/04413/2020). Publisher Copyright: © 2023 by the authors.Leishmaniasis is a parasitic disease caused by different species of Leishmania and transmitted through the bite of sand flies vector. Macrophages (MΦ), the target cells of Leishmania parasites, are phagocytes that play a crucial role in the innate immune microbial defense and are antigen-presenting cells driving the activation of the acquired immune response. Exploring parasite–host communication may be key in restraining parasite dissemination in the host. Extracellular vesicles (EVs) constitute a group of heterogenous cell-derived membranous structures, naturally produced by all cells and with immunomodulatory potential over target cells. This study examined the immunogenic potential of EVs shed by L. shawi and L. guyanensis in MΦ activation by analyzing the dynamics of major histocompatibility complex (MHC), innate immune receptors, and cytokine generation. L. shawi and L. guyanensis EVs were incorporated by MΦ and modulated innate immune receptors, indicating that EVs cargo can be recognized by MΦ sensors. Moreover, EVs induced MΦ to generate a mix of pro- and anti-inflammatory cytokines and favored the expression of MHCI molecules, suggesting that EVs antigens can be present to T cells, activating the acquired immune response of the host. Since nano-sized vesicles can be used as vehicles of immune mediators or immunomodulatory drugs, parasitic EVs can be exploited by bioengineering approaches for the development of efficient prophylactic or therapeutic tools for leishmaniasis.Vector borne diseases and pathogens (VBD)Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)RUNWeber, Juliana InêsRodrigues, Armanda VianaValério-Bolas, AnaNunes, TelmoCarvalheiro, ManuelaAntunes, WilsonAlexandre-Pires, Graçada Fonseca, Isabel PereiraSantos-Gomes, Gabriela2023-07-17T22:15:27Z2023-042023-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article25application/pdfhttp://hdl.handle.net/10362/155416eng2073-4409PURE: 64196786https://doi.org/10.3390/cells12081101info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:58Zoai:run.unl.pt:10362/155416Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:56:03.180566Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis
title Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis
spellingShingle Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis
Weber, Juliana Inês
extracellular vesicles
immunomodulation
Leishmania guyanensis
Leishmania shawi
leishmaniasis
macrophages
QR180 Immunology
QR Microbiology
Biochemistry, Genetics and Molecular Biology(all)
Parasitology
Immunology
SDG 3 - Good Health and Well-being
title_short Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis
title_full Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis
title_fullStr Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis
title_full_unstemmed Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis
title_sort Insights on Host–Parasite Immunomodulation Mediated by Extracellular Vesicles of Cutaneous Leishmania shawi and Leishmania guyanensis
author Weber, Juliana Inês
author_facet Weber, Juliana Inês
Rodrigues, Armanda Viana
Valério-Bolas, Ana
Nunes, Telmo
Carvalheiro, Manuela
Antunes, Wilson
Alexandre-Pires, Graça
da Fonseca, Isabel Pereira
Santos-Gomes, Gabriela
author_role author
author2 Rodrigues, Armanda Viana
Valério-Bolas, Ana
Nunes, Telmo
Carvalheiro, Manuela
Antunes, Wilson
Alexandre-Pires, Graça
da Fonseca, Isabel Pereira
Santos-Gomes, Gabriela
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Vector borne diseases and pathogens (VBD)
Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
RUN
dc.contributor.author.fl_str_mv Weber, Juliana Inês
Rodrigues, Armanda Viana
Valério-Bolas, Ana
Nunes, Telmo
Carvalheiro, Manuela
Antunes, Wilson
Alexandre-Pires, Graça
da Fonseca, Isabel Pereira
Santos-Gomes, Gabriela
dc.subject.por.fl_str_mv extracellular vesicles
immunomodulation
Leishmania guyanensis
Leishmania shawi
leishmaniasis
macrophages
QR180 Immunology
QR Microbiology
Biochemistry, Genetics and Molecular Biology(all)
Parasitology
Immunology
SDG 3 - Good Health and Well-being
topic extracellular vesicles
immunomodulation
Leishmania guyanensis
Leishmania shawi
leishmaniasis
macrophages
QR180 Immunology
QR Microbiology
Biochemistry, Genetics and Molecular Biology(all)
Parasitology
Immunology
SDG 3 - Good Health and Well-being
description Funding Information: This study was supported by FCT-Foundation for Science and Technology, I.P., through research grant PTDC/CVT-CVT/28908/2017 and PTDC/CVT-CVT/0228/2020 and by national funds within the scope of Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020) and Global Health and Tropical Medicine (GHTM, UID/04413/2020). Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-17T22:15:27Z
2023-04
2023-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/155416
url http://hdl.handle.net/10362/155416
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2073-4409
PURE: 64196786
https://doi.org/10.3390/cells12081101
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 25
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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