Does salinity modulates the response of Mytilus galloprovincialis exposed to triclosan and diclofenac?

• Autor(a) principal: Freitas, Rosa
• Data de Publicação: 2019
• Outros Autores: Coppola, Francesca, Costa, Silvana, Manzini, Chiara, Intorre, Luigi, Meucci, Valentina, Soares, Amadeu M. V. M., Pretti, Carlo, Solé, Montserrat
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10773/27450
• topic: Pharmaceuticals and personal care products; Bivalves; Oxidative stress; Energy metabolism; Extreme weather events

In the present study Mytilus galloprovincialis mussels were exposed for 28 days to three salinities: 30 (control), 25 and 35. Simultaneously, organisms at each salinity were exposed to either the antimicrobial agent Triclosan (TCS) or the pharmaceutical drug Diclofenac (DIC) at 1 μg/L. Salinity alone and exposure to PPCPs changed mussel's metabolic capacity and oxidative status, but no additive or synergetic effects resulting from the combined exposures were observed. Overall, the metabolic capacity of mussels was decreased when exposed to TCS and DIC under control salinity, which was less pronounced at salinities out of the control level. TCS had a notorious effect over glutathione peroxidase activity while DIC exposure enhanced catalase response. Such defence mechanisms were able to prevent cellular damage but still a clear reduction in GSH/GSSG ratio after PPCPs exposures indicates oxidative stress which could compromise bivalve's performance to further stressing events.