Role of biological medicines in chronic rhinosinusitis with nasal polyps - Systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Vila-Real-Fernandes, João
Data de Publicação: 2023
Outros Autores: Cerejeira, Rui, Veloso-Teles, Rafaela
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.34631/sporl.1063
Resumo: Introduction: Chronic rhinosinusitis with nasal polyps is an inflammatory disease associated with high morbidity and quality of life impairment. The aim of this article is to evaluate the efficacy of new monoclonal therapies in the control of disease refractory to the available therapies and to discuss the multiple factors that should be taken into consideration in the use of these types of drugs. Methods: Systematic review with meta-analysis on the efficacy of biological therapies in chronic rhinosinusitis with nasal polyps. It was also assessed, through a review of the relevant literature, the cost-benefit of biologic treatments. Results: In total, the meta-analysis included 11 randomized clinical trials that evaluated 4 monoclonal antibodies and all antibodies showed improvement in quality of life and a positive impact on the extent of the disease, despite its huge economical burden. Conclusion: In this systematic review, we were able to verify that dupilumab was the monoclonal antibody with the greatest impact, both on quality of life and on the extent of the disease. However, further studies are needed in the future to better assess the long-term effect of these new therapies. Furthermore, given the economic impact of its use, it is imperative to efficiently assess which patients benefit the most from biologic therapies.
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spelling Role of biological medicines in chronic rhinosinusitis with nasal polyps - Systematic review and meta-analysisPapel dos medicamentos biológicos na rinossinusite crónica com pólipos nasais - Revisão sistemática com meta-análiseRinossinusite crónicaPólipos nasaisAnticorpos monoclonaisBiológicosChronic rhinosinusitisNasal polypsMonoclonal antibodiesBiologicsIntroduction: Chronic rhinosinusitis with nasal polyps is an inflammatory disease associated with high morbidity and quality of life impairment. The aim of this article is to evaluate the efficacy of new monoclonal therapies in the control of disease refractory to the available therapies and to discuss the multiple factors that should be taken into consideration in the use of these types of drugs. Methods: Systematic review with meta-analysis on the efficacy of biological therapies in chronic rhinosinusitis with nasal polyps. It was also assessed, through a review of the relevant literature, the cost-benefit of biologic treatments. Results: In total, the meta-analysis included 11 randomized clinical trials that evaluated 4 monoclonal antibodies and all antibodies showed improvement in quality of life and a positive impact on the extent of the disease, despite its huge economical burden. Conclusion: In this systematic review, we were able to verify that dupilumab was the monoclonal antibody with the greatest impact, both on quality of life and on the extent of the disease. However, further studies are needed in the future to better assess the long-term effect of these new therapies. Furthermore, given the economic impact of its use, it is imperative to efficiently assess which patients benefit the most from biologic therapies.Introdução: A rinossinusite crónica com pólipos nasais é uma doença inflamatória associada a elevada morbilidade e diminuição da qualidade de vida. O objetivo deste artigo é avaliar a eficácia das novas terapias monoclonais no controlo da doença refratária às terapêuticas disponíveis e discutir os múltiplos fatores que devem ser tidos em conta no uso destes fármacos. Métodos: Revisão sistemática com meta-análise sobre a eficácia das terapias biológicas na rinossinusite crónica com pólipos nasais. Foi efetuada também a revisão da literatura pertinente acerca do custo-benef ício dos medicamentos biológicos. Resultados: No total, a meta-análise incluiu 11 ensaios clínicos randomizados, que avaliaram 4 anticorpos monoclonais em que todos os anticorpos demonstraram melhorias na qualidade de vida e diminuição da extensão da doença, acarretando no entanto um elevado custo financeiro. Conclusão: Nesta revisão sistemática verificou-se que o dupilumab foi o anticorpo monoclonal com mais impacto, tanto na qualidade de vida como na extensão da doença. No entanto, são necessários mais estudos que avaliem o efeito a longo prazo destas novas terapêuticas. Além disso, dado o impacto económico que implica a utilização de medicamentos biológicos, é imperioso que se avalie de forma eficiente quais os doentes que mais beneficiam com esta terapêutica.Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço2023-03-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://doi.org/10.34631/sporl.1063https://doi.org/10.34631/sporl.1063Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 61 No. 1 (2023): March; 71-88Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 61 Núm. 1 (2023): Março; 71-88Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 61 N.º 1 (2023): Março; 71-882184-6499reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPengporhttps://journalsporl.com/index.php/sporl/article/view/2013https://journalsporl.com/index.php/sporl/article/view/2013/19https://journalsporl.com/index.php/sporl/article/view/2013/20Direitos de Autor (c) 2023 Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoçoinfo:eu-repo/semantics/openAccessVila-Real-Fernandes, JoãoCerejeira, RuiVeloso-Teles, Rafaela2023-11-09T12:00:31Zoai:journalsporl.com:article/2013Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:10:08.129146Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Role of biological medicines in chronic rhinosinusitis with nasal polyps - Systematic review and meta-analysis
Papel dos medicamentos biológicos na rinossinusite crónica com pólipos nasais - Revisão sistemática com meta-análise
title Role of biological medicines in chronic rhinosinusitis with nasal polyps - Systematic review and meta-analysis
spellingShingle Role of biological medicines in chronic rhinosinusitis with nasal polyps - Systematic review and meta-analysis
Vila-Real-Fernandes, João
Rinossinusite crónica
Pólipos nasais
Anticorpos monoclonais
Biológicos
Chronic rhinosinusitis
Nasal polyps
Monoclonal antibodies
Biologics
title_short Role of biological medicines in chronic rhinosinusitis with nasal polyps - Systematic review and meta-analysis
title_full Role of biological medicines in chronic rhinosinusitis with nasal polyps - Systematic review and meta-analysis
title_fullStr Role of biological medicines in chronic rhinosinusitis with nasal polyps - Systematic review and meta-analysis
title_full_unstemmed Role of biological medicines in chronic rhinosinusitis with nasal polyps - Systematic review and meta-analysis
title_sort Role of biological medicines in chronic rhinosinusitis with nasal polyps - Systematic review and meta-analysis
author Vila-Real-Fernandes, João
author_facet Vila-Real-Fernandes, João
Cerejeira, Rui
Veloso-Teles, Rafaela
author_role author
author2 Cerejeira, Rui
Veloso-Teles, Rafaela
author2_role author
author
dc.contributor.author.fl_str_mv Vila-Real-Fernandes, João
Cerejeira, Rui
Veloso-Teles, Rafaela
dc.subject.por.fl_str_mv Rinossinusite crónica
Pólipos nasais
Anticorpos monoclonais
Biológicos
Chronic rhinosinusitis
Nasal polyps
Monoclonal antibodies
Biologics
topic Rinossinusite crónica
Pólipos nasais
Anticorpos monoclonais
Biológicos
Chronic rhinosinusitis
Nasal polyps
Monoclonal antibodies
Biologics
description Introduction: Chronic rhinosinusitis with nasal polyps is an inflammatory disease associated with high morbidity and quality of life impairment. The aim of this article is to evaluate the efficacy of new monoclonal therapies in the control of disease refractory to the available therapies and to discuss the multiple factors that should be taken into consideration in the use of these types of drugs. Methods: Systematic review with meta-analysis on the efficacy of biological therapies in chronic rhinosinusitis with nasal polyps. It was also assessed, through a review of the relevant literature, the cost-benefit of biologic treatments. Results: In total, the meta-analysis included 11 randomized clinical trials that evaluated 4 monoclonal antibodies and all antibodies showed improvement in quality of life and a positive impact on the extent of the disease, despite its huge economical burden. Conclusion: In this systematic review, we were able to verify that dupilumab was the monoclonal antibody with the greatest impact, both on quality of life and on the extent of the disease. However, further studies are needed in the future to better assess the long-term effect of these new therapies. Furthermore, given the economic impact of its use, it is imperative to efficiently assess which patients benefit the most from biologic therapies.
publishDate 2023
dc.date.none.fl_str_mv 2023-03-16
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.34631/sporl.1063
https://doi.org/10.34631/sporl.1063
url https://doi.org/10.34631/sporl.1063
dc.language.iso.fl_str_mv eng
por
language eng
por
dc.relation.none.fl_str_mv https://journalsporl.com/index.php/sporl/article/view/2013
https://journalsporl.com/index.php/sporl/article/view/2013/19
https://journalsporl.com/index.php/sporl/article/view/2013/20
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
publisher.none.fl_str_mv Sociedade Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
dc.source.none.fl_str_mv Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery; Vol. 61 No. 1 (2023): March; 71-88
Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Vol. 61 Núm. 1 (2023): Março; 71-88
Revista Portuguesa de Otorrinolaringologia-Cirurgia de Cabeça e Pescoço; Vol. 61 N.º 1 (2023): Março; 71-88
2184-6499
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