Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distribution
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/25190 |
Resumo: | Terpenes and terpenoids encompass one of the most extensive and valuable classes of secondary metabolites. Their ten-carbon-containing oxygenated representatives, monoterpenoids, are the main components of plant essential oils, being widely exploited in the cosmetic, pharmaceutical, and food industrial areas. Due to its widespread use, it is crucial to investigate their environmental distribution. Thus, new water solubility data were obtained for six monoterpenoids ((1R)-(+)-camphor, (S)-(+)-carvone, eucalyptol, (1R)- (−)-fenchone, L-(−)-menthol, and (−)-menthone) at 298.2 and 313.2 K. Furthermore, octanol−water partition coefficients of 12 monoterpenoids (the six mentioned above plus carvacrol, (±)-β-citronellol, eugenol, geraniol, linalool, and thymol) were measured at 298.2 K. The COSMO-RS thermodynamic model and other more empirical approaches were evaluated for the description of the solubilities and partition coefficients, showing reliable predictions. Lastly, the distribution of the monoterpenoids in the different environmental compartments was assessed through an intuitive two-dimensional chemical space diagram based on the physicochemical equilibrium information reported. |
id |
RCAP_1b3743d87e5539b5489896d956aa2f7d |
---|---|
oai_identifier_str |
oai:bibliotecadigital.ipb.pt:10198/25190 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distributionEssential oilsMetabolitesSolubilityTerpenes and terpenoids encompass one of the most extensive and valuable classes of secondary metabolites. Their ten-carbon-containing oxygenated representatives, monoterpenoids, are the main components of plant essential oils, being widely exploited in the cosmetic, pharmaceutical, and food industrial areas. Due to its widespread use, it is crucial to investigate their environmental distribution. Thus, new water solubility data were obtained for six monoterpenoids ((1R)-(+)-camphor, (S)-(+)-carvone, eucalyptol, (1R)- (−)-fenchone, L-(−)-menthol, and (−)-menthone) at 298.2 and 313.2 K. Furthermore, octanol−water partition coefficients of 12 monoterpenoids (the six mentioned above plus carvacrol, (±)-β-citronellol, eugenol, geraniol, linalool, and thymol) were measured at 298.2 K. The COSMO-RS thermodynamic model and other more empirical approaches were evaluated for the description of the solubilities and partition coefficients, showing reliable predictions. Lastly, the distribution of the monoterpenoids in the different environmental compartments was assessed through an intuitive two-dimensional chemical space diagram based on the physicochemical equilibrium information reported.This work was developed within the scope of the project CIMO-Mountain Research Center, UIDB/00690/2020, and CICECO-Aveiro Institute of Materials, UIDB/50011/2020 and UIDP/50011/2020, financed by national funds through the Portuguese Foundation for Science and Technology (FCT)/MCTES. S.M.V.-B. thanks FCT and the European Social Fund (ESF) for his Ph.D. grant (SFRH/BD/138149/2018). M.C.d.C. would also like to thank CNPq (306666/ 2020-0) and FAPESP (2014/21252-0).ACSBiblioteca Digital do IPBVilas-Boas, Sérgio M.Costa, Mariana C.Coutinho, João A.P.Ferreira, OlgaPinho, Simão2022-03-09T16:54:11Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/25190engVilas-Boas, Sérgio M.; Costa, Mariana C. Da; Coutinho, João A. P.; Ferreira, Olga; Pinho, Simão (2022). Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distribution. Industrial & Engineering Chemistry Research. ISSN 0888-5885. 61:8, p. 3154-3167ISSN 0888-588510.1021/acs.iecr.1c04196info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-20T01:18:22Zoai:bibliotecadigital.ipb.pt:10198/25190Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:15:53.523488Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distribution |
title |
Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distribution |
spellingShingle |
Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distribution Vilas-Boas, Sérgio M. Essential oils Metabolites Solubility |
title_short |
Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distribution |
title_full |
Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distribution |
title_fullStr |
Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distribution |
title_full_unstemmed |
Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distribution |
title_sort |
Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distribution |
author |
Vilas-Boas, Sérgio M. |
author_facet |
Vilas-Boas, Sérgio M. Costa, Mariana C. Coutinho, João A.P. Ferreira, Olga Pinho, Simão |
author_role |
author |
author2 |
Costa, Mariana C. Coutinho, João A.P. Ferreira, Olga Pinho, Simão |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Vilas-Boas, Sérgio M. Costa, Mariana C. Coutinho, João A.P. Ferreira, Olga Pinho, Simão |
dc.subject.por.fl_str_mv |
Essential oils Metabolites Solubility |
topic |
Essential oils Metabolites Solubility |
description |
Terpenes and terpenoids encompass one of the most extensive and valuable classes of secondary metabolites. Their ten-carbon-containing oxygenated representatives, monoterpenoids, are the main components of plant essential oils, being widely exploited in the cosmetic, pharmaceutical, and food industrial areas. Due to its widespread use, it is crucial to investigate their environmental distribution. Thus, new water solubility data were obtained for six monoterpenoids ((1R)-(+)-camphor, (S)-(+)-carvone, eucalyptol, (1R)- (−)-fenchone, L-(−)-menthol, and (−)-menthone) at 298.2 and 313.2 K. Furthermore, octanol−water partition coefficients of 12 monoterpenoids (the six mentioned above plus carvacrol, (±)-β-citronellol, eugenol, geraniol, linalool, and thymol) were measured at 298.2 K. The COSMO-RS thermodynamic model and other more empirical approaches were evaluated for the description of the solubilities and partition coefficients, showing reliable predictions. Lastly, the distribution of the monoterpenoids in the different environmental compartments was assessed through an intuitive two-dimensional chemical space diagram based on the physicochemical equilibrium information reported. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-09T16:54:11Z 2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/25190 |
url |
http://hdl.handle.net/10198/25190 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Vilas-Boas, Sérgio M.; Costa, Mariana C. Da; Coutinho, João A. P.; Ferreira, Olga; Pinho, Simão (2022). Octanol–water partition coefficients and aqueous solubility data of monoterpenoids: experimental, modeling, and environmental distribution. Industrial & Engineering Chemistry Research. ISSN 0888-5885. 61:8, p. 3154-3167 ISSN 0888-5885 10.1021/acs.iecr.1c04196 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
ACS |
publisher.none.fl_str_mv |
ACS |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799135442749095936 |