Clinical 3-D Gait Assessment of Patients with Polyneuropathy Associated with Hereditary Transthyretin Amyloidosis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2631 |
Resumo: | Hereditary amyloidosis associated with transthyretin V30M (ATTRv V30M) is a rare and inherited multisystemic disease, with a variable presentation and a challenging diagnosis, follow-up and treatment. This condition entails a definitive and progressive motor impairment that compromises walking ability from near onset. The detection of the latter is key for the disease's diagnosis. The aim of this work is to perform quantitative 3-D gait analysis in ATTRv V30M patients, at different disease stages, and explore the potential of the obtained gait information for supporting early diagnosis and/or stage distinction during follow-up. Sixty-six subjects (25 healthy controls, 14 asymptomatic ATTRv V30M carriers, and 27 symptomatic patients) were included in this case-control study. All subjects were asked to walk back and forth for 2 min, in front of a Kinect v2 camera prepared for body motion tracking. We then used our own software to extract gait-related parameters from the camera's 3-D body data. For each parameter, the main subject groups and symptomatic patient subgroups were statistically compared. Most of the explored gait parameters can potentially be used to distinguish between the considered group pairs. Despite of statistically significant differences being found, most of them were undetected to the naked eye. Our Kinect camera-based system is easy to use in clinical settings and provides quantitative gait information that can be useful for supporting clinical assessment during ATTRv V30M onset detection and follow-up, as well as developing more objective and fine-grained rating scales to further support the clinical decisions. |
id |
RCAP_1b676f5bad60cdd1b0512ff41cd6334f |
---|---|
oai_identifier_str |
oai:repositorio.chporto.pt:10400.16/2631 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Clinical 3-D Gait Assessment of Patients with Polyneuropathy Associated with Hereditary Transthyretin AmyloidosisATTRv V30Mambulatoryamyloidosisgaitmarkerless vision-based systemspolyneuropathyHereditary amyloidosis associated with transthyretin V30M (ATTRv V30M) is a rare and inherited multisystemic disease, with a variable presentation and a challenging diagnosis, follow-up and treatment. This condition entails a definitive and progressive motor impairment that compromises walking ability from near onset. The detection of the latter is key for the disease's diagnosis. The aim of this work is to perform quantitative 3-D gait analysis in ATTRv V30M patients, at different disease stages, and explore the potential of the obtained gait information for supporting early diagnosis and/or stage distinction during follow-up. Sixty-six subjects (25 healthy controls, 14 asymptomatic ATTRv V30M carriers, and 27 symptomatic patients) were included in this case-control study. All subjects were asked to walk back and forth for 2 min, in front of a Kinect v2 camera prepared for body motion tracking. We then used our own software to extract gait-related parameters from the camera's 3-D body data. For each parameter, the main subject groups and symptomatic patient subgroups were statistically compared. Most of the explored gait parameters can potentially be used to distinguish between the considered group pairs. Despite of statistically significant differences being found, most of them were undetected to the naked eye. Our Kinect camera-based system is easy to use in clinical settings and provides quantitative gait information that can be useful for supporting clinical assessment during ATTRv V30M onset detection and follow-up, as well as developing more objective and fine-grained rating scales to further support the clinical decisions.This work was supported by the National funding agency, FCT—Fundação para a Ciência e a Tecnologia, in the context of the projects (UIDB/50014/2020; UIDB/00127/2020) and scholarship (SFRH/DB/110438/2015). This work was also supported by the Porto University Hospital Center (CHUP) in the context of the scholarship (BI.02/2018/UCA/CHP) as part of the research project [2014/167(119-DEFI/149-CES)]Frontiers Research FoundationRepositório Científico do Centro Hospitalar Universitário de Santo AntónioVilas-Boas, Maria do CarmoRocha, Ana PatríciaCardoso, Márcio NevesFernandes, José MariaCoelho, TeresaCunha, João Paulo Silva2021-12-06T10:39:02Z2020-11-232020-11-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2631engVilas-Boas MDC, Rocha AP, Cardoso MN, Fernandes JM, Coelho T, Cunha JPS. Clinical 3-D Gait Assessment of Patients With Polyneuropathy Associated With Hereditary Transthyretin Amyloidosis. Front Neurol. 2020;11:605282. doi:10.3389/fneur.2020.6052821664-229510.3389/fneur.2020.605282info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:01:23Zoai:repositorio.chporto.pt:10400.16/2631Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:49.991245Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Clinical 3-D Gait Assessment of Patients with Polyneuropathy Associated with Hereditary Transthyretin Amyloidosis |
title |
Clinical 3-D Gait Assessment of Patients with Polyneuropathy Associated with Hereditary Transthyretin Amyloidosis |
spellingShingle |
Clinical 3-D Gait Assessment of Patients with Polyneuropathy Associated with Hereditary Transthyretin Amyloidosis Vilas-Boas, Maria do Carmo ATTRv V30M ambulatory amyloidosis gait markerless vision-based systems polyneuropathy |
title_short |
Clinical 3-D Gait Assessment of Patients with Polyneuropathy Associated with Hereditary Transthyretin Amyloidosis |
title_full |
Clinical 3-D Gait Assessment of Patients with Polyneuropathy Associated with Hereditary Transthyretin Amyloidosis |
title_fullStr |
Clinical 3-D Gait Assessment of Patients with Polyneuropathy Associated with Hereditary Transthyretin Amyloidosis |
title_full_unstemmed |
Clinical 3-D Gait Assessment of Patients with Polyneuropathy Associated with Hereditary Transthyretin Amyloidosis |
title_sort |
Clinical 3-D Gait Assessment of Patients with Polyneuropathy Associated with Hereditary Transthyretin Amyloidosis |
author |
Vilas-Boas, Maria do Carmo |
author_facet |
Vilas-Boas, Maria do Carmo Rocha, Ana Patrícia Cardoso, Márcio Neves Fernandes, José Maria Coelho, Teresa Cunha, João Paulo Silva |
author_role |
author |
author2 |
Rocha, Ana Patrícia Cardoso, Márcio Neves Fernandes, José Maria Coelho, Teresa Cunha, João Paulo Silva |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Vilas-Boas, Maria do Carmo Rocha, Ana Patrícia Cardoso, Márcio Neves Fernandes, José Maria Coelho, Teresa Cunha, João Paulo Silva |
dc.subject.por.fl_str_mv |
ATTRv V30M ambulatory amyloidosis gait markerless vision-based systems polyneuropathy |
topic |
ATTRv V30M ambulatory amyloidosis gait markerless vision-based systems polyneuropathy |
description |
Hereditary amyloidosis associated with transthyretin V30M (ATTRv V30M) is a rare and inherited multisystemic disease, with a variable presentation and a challenging diagnosis, follow-up and treatment. This condition entails a definitive and progressive motor impairment that compromises walking ability from near onset. The detection of the latter is key for the disease's diagnosis. The aim of this work is to perform quantitative 3-D gait analysis in ATTRv V30M patients, at different disease stages, and explore the potential of the obtained gait information for supporting early diagnosis and/or stage distinction during follow-up. Sixty-six subjects (25 healthy controls, 14 asymptomatic ATTRv V30M carriers, and 27 symptomatic patients) were included in this case-control study. All subjects were asked to walk back and forth for 2 min, in front of a Kinect v2 camera prepared for body motion tracking. We then used our own software to extract gait-related parameters from the camera's 3-D body data. For each parameter, the main subject groups and symptomatic patient subgroups were statistically compared. Most of the explored gait parameters can potentially be used to distinguish between the considered group pairs. Despite of statistically significant differences being found, most of them were undetected to the naked eye. Our Kinect camera-based system is easy to use in clinical settings and provides quantitative gait information that can be useful for supporting clinical assessment during ATTRv V30M onset detection and follow-up, as well as developing more objective and fine-grained rating scales to further support the clinical decisions. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11-23 2020-11-23T00:00:00Z 2021-12-06T10:39:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2631 |
url |
http://hdl.handle.net/10400.16/2631 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Vilas-Boas MDC, Rocha AP, Cardoso MN, Fernandes JM, Coelho T, Cunha JPS. Clinical 3-D Gait Assessment of Patients With Polyneuropathy Associated With Hereditary Transthyretin Amyloidosis. Front Neurol. 2020;11:605282. doi:10.3389/fneur.2020.605282 1664-2295 10.3389/fneur.2020.605282 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Research Foundation |
publisher.none.fl_str_mv |
Frontiers Research Foundation |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133648507633664 |