Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/40225 |
Resumo: | Short nighttime sleep duration impairs the immune response to virus vaccination, and long nighttime sleep duration is associated with poor health status. Thus, we hypothesized that short (<6 h) and long (>9 h) nighttime sleepers have a higher post-COVID risk than normal nighttime sleepers, despite two doses of mRNA vaccine (which has previously been linked to lower odds of long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core COVID-19 symptom for at least three months (e.g., shortness of breath). Multivariate logistic regression adjusting for age, sex, BMI, and other factors showed in 9717 respondents (age span 18–99) that two mRNA vaccinations lowered the risk of suffering from post-COVID by about 21% (p < 0.001). When restricting the analysis to double-vaccinated respondents (n = 5918), short and long sleepers exhibited a greater post-COVID risk than normal sleepers (adjusted OR [95%-CI], 1.56 [1.29, 1.88] and 1.87 [1.32, 2.66], respectively). Among respondents with persistent sleep duration patterns during the pandemic compared to before the pandemic, short but not long sleep duration was significantly associated with the post-COVID risk (adjusted OR [95%-CI], 1.59 [1.24, 2.03] and 1.18 [0.70, 1.97], respectively). No significant association between sleep duration and post-COVID symptoms was observed in those reporting positive SARS-CoV-2 test results (n = 538). Our findings suggest that two mRNA vaccinations against SARS-CoV-2 are associated with a lower post-COVID risk. However, this protection may be less pronounced among those sleeping less than 6 h per night. Our findings warrant replication in cohorts with individuals with confirmed SARS-CoV-2 infection. |
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Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individualsShort nighttime sleep duration impairs the immune response to virus vaccination, and long nighttime sleep duration is associated with poor health status. Thus, we hypothesized that short (<6 h) and long (>9 h) nighttime sleepers have a higher post-COVID risk than normal nighttime sleepers, despite two doses of mRNA vaccine (which has previously been linked to lower odds of long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core COVID-19 symptom for at least three months (e.g., shortness of breath). Multivariate logistic regression adjusting for age, sex, BMI, and other factors showed in 9717 respondents (age span 18–99) that two mRNA vaccinations lowered the risk of suffering from post-COVID by about 21% (p < 0.001). When restricting the analysis to double-vaccinated respondents (n = 5918), short and long sleepers exhibited a greater post-COVID risk than normal sleepers (adjusted OR [95%-CI], 1.56 [1.29, 1.88] and 1.87 [1.32, 2.66], respectively). Among respondents with persistent sleep duration patterns during the pandemic compared to before the pandemic, short but not long sleep duration was significantly associated with the post-COVID risk (adjusted OR [95%-CI], 1.59 [1.24, 2.03] and 1.18 [0.70, 1.97], respectively). No significant association between sleep duration and post-COVID symptoms was observed in those reporting positive SARS-CoV-2 test results (n = 538). Our findings suggest that two mRNA vaccinations against SARS-CoV-2 are associated with a lower post-COVID risk. However, this protection may be less pronounced among those sleeping less than 6 h per night. Our findings warrant replication in cohorts with individuals with confirmed SARS-CoV-2 infection.Veritati - Repositório Institucional da Universidade Católica PortuguesaXue, PeiMerikanto, IlonaChung, FrancesMorin, Charles M.Espie, ColinBjorvatn, BjørnCedernaes, JonathanLandtblom, Anne MariePenzel, ThomasGennaro, Luigi deHolzinger, BrigitteMatsui, KentaroHrubos-Strøm, HaraldKorman, MariaLeger, DamienMota-Rolim, SérgioBolstad, Courtney J.Nadorff, MichaelPlazzi, GiuseppeReis, CátiaChan, Rachel Ngan YinWing, Yun KwokYordanova, JulianaBjelajac, Adrijana KoscecInoue, YuichiPartinen, MarkkuDauvilliers, YvesBenedict, Christian2023-02-15T10:09:14Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/40225eng2158-318810.1038/s41398-023-02334-485147176439PMC989041636726008000923536600001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-12T17:45:46Zoai:repositorio.ucp.pt:10400.14/40225Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:32:57.606177Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
title |
Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
spellingShingle |
Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals Xue, Pei |
title_short |
Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
title_full |
Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
title_fullStr |
Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
title_full_unstemmed |
Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
title_sort |
Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals |
author |
Xue, Pei |
author_facet |
Xue, Pei Merikanto, Ilona Chung, Frances Morin, Charles M. Espie, Colin Bjorvatn, Bjørn Cedernaes, Jonathan Landtblom, Anne Marie Penzel, Thomas Gennaro, Luigi de Holzinger, Brigitte Matsui, Kentaro Hrubos-Strøm, Harald Korman, Maria Leger, Damien Mota-Rolim, Sérgio Bolstad, Courtney J. Nadorff, Michael Plazzi, Giuseppe Reis, Cátia Chan, Rachel Ngan Yin Wing, Yun Kwok Yordanova, Juliana Bjelajac, Adrijana Koscec Inoue, Yuichi Partinen, Markku Dauvilliers, Yves Benedict, Christian |
author_role |
author |
author2 |
Merikanto, Ilona Chung, Frances Morin, Charles M. Espie, Colin Bjorvatn, Bjørn Cedernaes, Jonathan Landtblom, Anne Marie Penzel, Thomas Gennaro, Luigi de Holzinger, Brigitte Matsui, Kentaro Hrubos-Strøm, Harald Korman, Maria Leger, Damien Mota-Rolim, Sérgio Bolstad, Courtney J. Nadorff, Michael Plazzi, Giuseppe Reis, Cátia Chan, Rachel Ngan Yin Wing, Yun Kwok Yordanova, Juliana Bjelajac, Adrijana Koscec Inoue, Yuichi Partinen, Markku Dauvilliers, Yves Benedict, Christian |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Xue, Pei Merikanto, Ilona Chung, Frances Morin, Charles M. Espie, Colin Bjorvatn, Bjørn Cedernaes, Jonathan Landtblom, Anne Marie Penzel, Thomas Gennaro, Luigi de Holzinger, Brigitte Matsui, Kentaro Hrubos-Strøm, Harald Korman, Maria Leger, Damien Mota-Rolim, Sérgio Bolstad, Courtney J. Nadorff, Michael Plazzi, Giuseppe Reis, Cátia Chan, Rachel Ngan Yin Wing, Yun Kwok Yordanova, Juliana Bjelajac, Adrijana Koscec Inoue, Yuichi Partinen, Markku Dauvilliers, Yves Benedict, Christian |
description |
Short nighttime sleep duration impairs the immune response to virus vaccination, and long nighttime sleep duration is associated with poor health status. Thus, we hypothesized that short (<6 h) and long (>9 h) nighttime sleepers have a higher post-COVID risk than normal nighttime sleepers, despite two doses of mRNA vaccine (which has previously been linked to lower odds of long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core COVID-19 symptom for at least three months (e.g., shortness of breath). Multivariate logistic regression adjusting for age, sex, BMI, and other factors showed in 9717 respondents (age span 18–99) that two mRNA vaccinations lowered the risk of suffering from post-COVID by about 21% (p < 0.001). When restricting the analysis to double-vaccinated respondents (n = 5918), short and long sleepers exhibited a greater post-COVID risk than normal sleepers (adjusted OR [95%-CI], 1.56 [1.29, 1.88] and 1.87 [1.32, 2.66], respectively). Among respondents with persistent sleep duration patterns during the pandemic compared to before the pandemic, short but not long sleep duration was significantly associated with the post-COVID risk (adjusted OR [95%-CI], 1.59 [1.24, 2.03] and 1.18 [0.70, 1.97], respectively). No significant association between sleep duration and post-COVID symptoms was observed in those reporting positive SARS-CoV-2 test results (n = 538). Our findings suggest that two mRNA vaccinations against SARS-CoV-2 are associated with a lower post-COVID risk. However, this protection may be less pronounced among those sleeping less than 6 h per night. Our findings warrant replication in cohorts with individuals with confirmed SARS-CoV-2 infection. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-02-15T10:09:14Z 2023-12 2023-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/40225 |
url |
http://hdl.handle.net/10400.14/40225 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2158-3188 10.1038/s41398-023-02334-4 85147176439 PMC9890416 36726008 000923536600001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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