A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids

Detalhes bibliográficos
Autor(a) principal: Silva, Joana M.
Data de Publicação: 2019
Outros Autores: Silva, Eduardo, Reis, Rui L., Duarte, Ana Rita C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/104464
Resumo: Foundation for Science and Tech-nology, through project PTDC/BBB- 490 EBB/1676/2014 – Des.Zyme and post-doctoral grant SFRH/BPD/116779/2016. The authors would also like to acknowledge the financial support by ERC-2016-CoG 725034 (ERC Consolidator Grant Des.solve)
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spelling A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acidsAntimicrobialBiofilmDeep eutectic solventsGreen chemistrySaturated fatty acidsEnvironmental ChemistryPollutionPharmaceutical ScienceManagement, Monitoring, Policy and LawFoundation for Science and Tech-nology, through project PTDC/BBB- 490 EBB/1676/2014 – Des.Zyme and post-doctoral grant SFRH/BPD/116779/2016. The authors would also like to acknowledge the financial support by ERC-2016-CoG 725034 (ERC Consolidator Grant Des.solve)Microbial infection is a serious and challenging clinical complication that has attracted widespread interest in last decades. In this context, we present a strategy based on deep eutectic solvents (DES) to explore these unmet medical needs. DES systems based on saturated fatty acids, namely, capric acid (CA), myristic acid (MA), lauric acid (LA) and stearic acid (SA) were produced and fully characterized at a physicochemical level. The thermal characterization results indicate a depression of the melting point in DES form when compared with the starting compounds to near-physiological levels, whereas via polarized optic microscopy insights on the homogeneity/separation of the counterparts were obtained. Regarding, physicochemical properties, temperature also has a great effect on the viscosity of the eutectic systems, the higher the temperature the lower the viscosity observed. The antimicrobial potential of DES systems was evaluated against a broad spectrum of microorganisms. The obtained results show that DES retain the antimicrobial of the counterparts possibly present synergistic effects between components, mainly in the CA:MA formulation. The systems revealed significant antimicrobial activity against the tested Gram-positive bacteria and C. albicans, with the CA:LA system showing the greatest overall inhibitory/bactericidal activity. This system was then used for a biofilm removal/detachment assay where relevant activity is evident against the prementioned organisms and E. coli without need of additional physical force. The obtained results illustrate the potential of saturated fatty acid-based DES when compared with isolated fatty acids as preventive/therapeutic options against microbial infections and/or components of novel thermoresponsive biomedical devices for antibacterial purposes.DQ - Departamento de QuímicaLAQV@REQUIMTERUNSilva, Joana M.Silva, EduardoReis, Rui L.Duarte, Ana Rita C.2020-09-21T22:17:02Z2019-122019-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/104464eng2352-5541PURE: 19002931https://doi.org/10.1016/j.scp.2019.100192info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:49:58Zoai:run.unl.pt:10362/104464Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:40:14.137996Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids
title A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids
spellingShingle A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids
Silva, Joana M.
Antimicrobial
Biofilm
Deep eutectic solvents
Green chemistry
Saturated fatty acids
Environmental Chemistry
Pollution
Pharmaceutical Science
Management, Monitoring, Policy and Law
title_short A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids
title_full A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids
title_fullStr A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids
title_full_unstemmed A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids
title_sort A closer look in the antimicrobial properties of deep eutectic solvents based on fatty acids
author Silva, Joana M.
author_facet Silva, Joana M.
Silva, Eduardo
Reis, Rui L.
Duarte, Ana Rita C.
author_role author
author2 Silva, Eduardo
Reis, Rui L.
Duarte, Ana Rita C.
author2_role author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Silva, Joana M.
Silva, Eduardo
Reis, Rui L.
Duarte, Ana Rita C.
dc.subject.por.fl_str_mv Antimicrobial
Biofilm
Deep eutectic solvents
Green chemistry
Saturated fatty acids
Environmental Chemistry
Pollution
Pharmaceutical Science
Management, Monitoring, Policy and Law
topic Antimicrobial
Biofilm
Deep eutectic solvents
Green chemistry
Saturated fatty acids
Environmental Chemistry
Pollution
Pharmaceutical Science
Management, Monitoring, Policy and Law
description Foundation for Science and Tech-nology, through project PTDC/BBB- 490 EBB/1676/2014 – Des.Zyme and post-doctoral grant SFRH/BPD/116779/2016. The authors would also like to acknowledge the financial support by ERC-2016-CoG 725034 (ERC Consolidator Grant Des.solve)
publishDate 2019
dc.date.none.fl_str_mv 2019-12
2019-12-01T00:00:00Z
2020-09-21T22:17:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/104464
url http://hdl.handle.net/10362/104464
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2352-5541
PURE: 19002931
https://doi.org/10.1016/j.scp.2019.100192
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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