Renal transplantation in an HIV-2 positive recipient in Portugal

Detalhes bibliográficos
Autor(a) principal: Natário,Ana
Data de Publicação: 2012
Outros Autores: Rodrigues,Bruno, Matias,Patrícia, Jorge,Cristina, Bruges,Margarida, Birne,Rita, Miranda,Ana, Mansinho,Kamal, Machado,Domingos, Weigert,André
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692012000200007
Resumo: The improvement of combined antiretroviral therapy regimens has made solid organ transplantation a therapeutic option for patients with human immunodeficiency virus (HIV) infection. Generally, HIV-2 infectionpresents a slower clinical progression and immunological degradation than HIV-1. HIV-2 infection treatment can be challenging when a complex immunosuppressive regimen is combined with antiretroviraltherapy. The authors report the first case in Portugal of renal transplantation in an HIV-2 patient. A 54-year-old man from Guinea-Bissau was diagnosed with HIV-2 infection on starting haemodialysis in Portugal in 1998. At diagnosis, HIV infection staging revealed undetectable plasma HIV- 2 RNA and T-cell CD4 counts of 808 cells/μl, with no need for combined antiretroviral therapy during follow-up. The patient underwent renal transplantation from a deceased donor in March 2011. He developed delayed graft function and started therapy with methylprednisolone and thymoglobulin. The patient gradually recovered renal function and was discharged after two weeks with serum creatinine of 2.3 mg/dL. The HIV-2 RNA levels remained undetectable, but T-cell CD4count decreased to less than 200 cells/μl and combined antiretroviral therapy with abacavir, lamivudine and raltegravir was started. Nine months after transplantation, the patient has a serum creatinine of 1.5 mg/dL and a nonreplicating HIV status
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spelling Renal transplantation in an HIV-2 positive recipient in PortugalAntiretroviral therapyHIV-2 infectionimmunosuppressive therapykidney transplantationThe improvement of combined antiretroviral therapy regimens has made solid organ transplantation a therapeutic option for patients with human immunodeficiency virus (HIV) infection. Generally, HIV-2 infectionpresents a slower clinical progression and immunological degradation than HIV-1. HIV-2 infection treatment can be challenging when a complex immunosuppressive regimen is combined with antiretroviraltherapy. The authors report the first case in Portugal of renal transplantation in an HIV-2 patient. A 54-year-old man from Guinea-Bissau was diagnosed with HIV-2 infection on starting haemodialysis in Portugal in 1998. At diagnosis, HIV infection staging revealed undetectable plasma HIV- 2 RNA and T-cell CD4 counts of 808 cells/μl, with no need for combined antiretroviral therapy during follow-up. The patient underwent renal transplantation from a deceased donor in March 2011. He developed delayed graft function and started therapy with methylprednisolone and thymoglobulin. The patient gradually recovered renal function and was discharged after two weeks with serum creatinine of 2.3 mg/dL. The HIV-2 RNA levels remained undetectable, but T-cell CD4count decreased to less than 200 cells/μl and combined antiretroviral therapy with abacavir, lamivudine and raltegravir was started. Nine months after transplantation, the patient has a serum creatinine of 1.5 mg/dL and a nonreplicating HIV statusSociedade Portuguesa de Nefrologia2012-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692012000200007Portuguese Journal of Nephrology & Hypertension v.26 n.2 2012reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692012000200007Natário,AnaRodrigues,BrunoMatias,PatríciaJorge,CristinaBruges,MargaridaBirne,RitaMiranda,AnaMansinho,KamalMachado,DomingosWeigert,Andréinfo:eu-repo/semantics/openAccess2024-02-06T17:04:39Zoai:scielo:S0872-01692012000200007Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:49.071782Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Renal transplantation in an HIV-2 positive recipient in Portugal
title Renal transplantation in an HIV-2 positive recipient in Portugal
spellingShingle Renal transplantation in an HIV-2 positive recipient in Portugal
Natário,Ana
Antiretroviral therapy
HIV-2 infection
immunosuppressive therapy
kidney transplantation
title_short Renal transplantation in an HIV-2 positive recipient in Portugal
title_full Renal transplantation in an HIV-2 positive recipient in Portugal
title_fullStr Renal transplantation in an HIV-2 positive recipient in Portugal
title_full_unstemmed Renal transplantation in an HIV-2 positive recipient in Portugal
title_sort Renal transplantation in an HIV-2 positive recipient in Portugal
author Natário,Ana
author_facet Natário,Ana
Rodrigues,Bruno
Matias,Patrícia
Jorge,Cristina
Bruges,Margarida
Birne,Rita
Miranda,Ana
Mansinho,Kamal
Machado,Domingos
Weigert,André
author_role author
author2 Rodrigues,Bruno
Matias,Patrícia
Jorge,Cristina
Bruges,Margarida
Birne,Rita
Miranda,Ana
Mansinho,Kamal
Machado,Domingos
Weigert,André
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Natário,Ana
Rodrigues,Bruno
Matias,Patrícia
Jorge,Cristina
Bruges,Margarida
Birne,Rita
Miranda,Ana
Mansinho,Kamal
Machado,Domingos
Weigert,André
dc.subject.por.fl_str_mv Antiretroviral therapy
HIV-2 infection
immunosuppressive therapy
kidney transplantation
topic Antiretroviral therapy
HIV-2 infection
immunosuppressive therapy
kidney transplantation
description The improvement of combined antiretroviral therapy regimens has made solid organ transplantation a therapeutic option for patients with human immunodeficiency virus (HIV) infection. Generally, HIV-2 infectionpresents a slower clinical progression and immunological degradation than HIV-1. HIV-2 infection treatment can be challenging when a complex immunosuppressive regimen is combined with antiretroviraltherapy. The authors report the first case in Portugal of renal transplantation in an HIV-2 patient. A 54-year-old man from Guinea-Bissau was diagnosed with HIV-2 infection on starting haemodialysis in Portugal in 1998. At diagnosis, HIV infection staging revealed undetectable plasma HIV- 2 RNA and T-cell CD4 counts of 808 cells/μl, with no need for combined antiretroviral therapy during follow-up. The patient underwent renal transplantation from a deceased donor in March 2011. He developed delayed graft function and started therapy with methylprednisolone and thymoglobulin. The patient gradually recovered renal function and was discharged after two weeks with serum creatinine of 2.3 mg/dL. The HIV-2 RNA levels remained undetectable, but T-cell CD4count decreased to less than 200 cells/μl and combined antiretroviral therapy with abacavir, lamivudine and raltegravir was started. Nine months after transplantation, the patient has a serum creatinine of 1.5 mg/dL and a nonreplicating HIV status
publishDate 2012
dc.date.none.fl_str_mv 2012-04-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692012000200007
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dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.26 n.2 2012
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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