Renal transplantation in an HIV-2 positive recipient in Portugal
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692012000200007 |
Resumo: | The improvement of combined antiretroviral therapy regimens has made solid organ transplantation a therapeutic option for patients with human immunodeficiency virus (HIV) infection. Generally, HIV-2 infectionpresents a slower clinical progression and immunological degradation than HIV-1. HIV-2 infection treatment can be challenging when a complex immunosuppressive regimen is combined with antiretroviraltherapy. The authors report the first case in Portugal of renal transplantation in an HIV-2 patient. A 54-year-old man from Guinea-Bissau was diagnosed with HIV-2 infection on starting haemodialysis in Portugal in 1998. At diagnosis, HIV infection staging revealed undetectable plasma HIV- 2 RNA and T-cell CD4 counts of 808 cells/μl, with no need for combined antiretroviral therapy during follow-up. The patient underwent renal transplantation from a deceased donor in March 2011. He developed delayed graft function and started therapy with methylprednisolone and thymoglobulin. The patient gradually recovered renal function and was discharged after two weeks with serum creatinine of 2.3 mg/dL. The HIV-2 RNA levels remained undetectable, but T-cell CD4count decreased to less than 200 cells/μl and combined antiretroviral therapy with abacavir, lamivudine and raltegravir was started. Nine months after transplantation, the patient has a serum creatinine of 1.5 mg/dL and a nonreplicating HIV status |
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Renal transplantation in an HIV-2 positive recipient in PortugalAntiretroviral therapyHIV-2 infectionimmunosuppressive therapykidney transplantationThe improvement of combined antiretroviral therapy regimens has made solid organ transplantation a therapeutic option for patients with human immunodeficiency virus (HIV) infection. Generally, HIV-2 infectionpresents a slower clinical progression and immunological degradation than HIV-1. HIV-2 infection treatment can be challenging when a complex immunosuppressive regimen is combined with antiretroviraltherapy. The authors report the first case in Portugal of renal transplantation in an HIV-2 patient. A 54-year-old man from Guinea-Bissau was diagnosed with HIV-2 infection on starting haemodialysis in Portugal in 1998. At diagnosis, HIV infection staging revealed undetectable plasma HIV- 2 RNA and T-cell CD4 counts of 808 cells/μl, with no need for combined antiretroviral therapy during follow-up. The patient underwent renal transplantation from a deceased donor in March 2011. He developed delayed graft function and started therapy with methylprednisolone and thymoglobulin. The patient gradually recovered renal function and was discharged after two weeks with serum creatinine of 2.3 mg/dL. The HIV-2 RNA levels remained undetectable, but T-cell CD4count decreased to less than 200 cells/μl and combined antiretroviral therapy with abacavir, lamivudine and raltegravir was started. Nine months after transplantation, the patient has a serum creatinine of 1.5 mg/dL and a nonreplicating HIV statusSociedade Portuguesa de Nefrologia2012-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692012000200007Portuguese Journal of Nephrology & Hypertension v.26 n.2 2012reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692012000200007Natário,AnaRodrigues,BrunoMatias,PatríciaJorge,CristinaBruges,MargaridaBirne,RitaMiranda,AnaMansinho,KamalMachado,DomingosWeigert,Andréinfo:eu-repo/semantics/openAccess2024-02-06T17:04:39Zoai:scielo:S0872-01692012000200007Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:18:49.071782Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Renal transplantation in an HIV-2 positive recipient in Portugal |
title |
Renal transplantation in an HIV-2 positive recipient in Portugal |
spellingShingle |
Renal transplantation in an HIV-2 positive recipient in Portugal Natário,Ana Antiretroviral therapy HIV-2 infection immunosuppressive therapy kidney transplantation |
title_short |
Renal transplantation in an HIV-2 positive recipient in Portugal |
title_full |
Renal transplantation in an HIV-2 positive recipient in Portugal |
title_fullStr |
Renal transplantation in an HIV-2 positive recipient in Portugal |
title_full_unstemmed |
Renal transplantation in an HIV-2 positive recipient in Portugal |
title_sort |
Renal transplantation in an HIV-2 positive recipient in Portugal |
author |
Natário,Ana |
author_facet |
Natário,Ana Rodrigues,Bruno Matias,Patrícia Jorge,Cristina Bruges,Margarida Birne,Rita Miranda,Ana Mansinho,Kamal Machado,Domingos Weigert,André |
author_role |
author |
author2 |
Rodrigues,Bruno Matias,Patrícia Jorge,Cristina Bruges,Margarida Birne,Rita Miranda,Ana Mansinho,Kamal Machado,Domingos Weigert,André |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Natário,Ana Rodrigues,Bruno Matias,Patrícia Jorge,Cristina Bruges,Margarida Birne,Rita Miranda,Ana Mansinho,Kamal Machado,Domingos Weigert,André |
dc.subject.por.fl_str_mv |
Antiretroviral therapy HIV-2 infection immunosuppressive therapy kidney transplantation |
topic |
Antiretroviral therapy HIV-2 infection immunosuppressive therapy kidney transplantation |
description |
The improvement of combined antiretroviral therapy regimens has made solid organ transplantation a therapeutic option for patients with human immunodeficiency virus (HIV) infection. Generally, HIV-2 infectionpresents a slower clinical progression and immunological degradation than HIV-1. HIV-2 infection treatment can be challenging when a complex immunosuppressive regimen is combined with antiretroviraltherapy. The authors report the first case in Portugal of renal transplantation in an HIV-2 patient. A 54-year-old man from Guinea-Bissau was diagnosed with HIV-2 infection on starting haemodialysis in Portugal in 1998. At diagnosis, HIV infection staging revealed undetectable plasma HIV- 2 RNA and T-cell CD4 counts of 808 cells/μl, with no need for combined antiretroviral therapy during follow-up. The patient underwent renal transplantation from a deceased donor in March 2011. He developed delayed graft function and started therapy with methylprednisolone and thymoglobulin. The patient gradually recovered renal function and was discharged after two weeks with serum creatinine of 2.3 mg/dL. The HIV-2 RNA levels remained undetectable, but T-cell CD4count decreased to less than 200 cells/μl and combined antiretroviral therapy with abacavir, lamivudine and raltegravir was started. Nine months after transplantation, the patient has a serum creatinine of 1.5 mg/dL and a nonreplicating HIV status |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692012000200007 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692012000200007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692012000200007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Nefrologia |
dc.source.none.fl_str_mv |
Portuguese Journal of Nephrology & Hypertension v.26 n.2 2012 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799137278320181248 |