Synthesis of novel beta-substituted alpha,beta-dehydroamino acid derivatives

Detalhes bibliográficos
Autor(a) principal: Ferreira, Paula M. T.
Data de Publicação: 2000
Outros Autores: Maia, Hernâni Lopes Silva, Monteiro, Luís S., Sacramento, Joana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/72912
Resumo: beta-Substituted alpha,beta-dehydroamino acids are synthesised in high yields by a Michael addition of heterocyclic nucleophiles to the methyl esters of N-tert-butyloxycarbonyl,N-(4-toluenesulfonyl)dehydroamino acids, followed by a base-induced elimination of the 4-toluenesulfonyl group with regeneration of the alpha,beta-double bond.
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spelling Synthesis of novel beta-substituted alpha,beta-dehydroamino acid derivativesalpha,beta-dehydroamino acidsbeta-substituted alaninesbeta-substituted alpha,beta-dehydroamino acidsα,β-Dehydroamino acidsβ-Substituted alaninesβ-Substituted α,β-dehydroamino acidsScience & Technologybeta-Substituted alpha,beta-dehydroamino acids are synthesised in high yields by a Michael addition of heterocyclic nucleophiles to the methyl esters of N-tert-butyloxycarbonyl,N-(4-toluenesulfonyl)dehydroamino acids, followed by a base-induced elimination of the 4-toluenesulfonyl group with regeneration of the alpha,beta-double bond.ElsevierUniversidade do MinhoFerreira, Paula M. T.Maia, Hernâni Lopes SilvaMonteiro, Luís S.Sacramento, Joana20002000-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/72912eng0040-403910.1016/S0040-4039(00)01271-5https://www.sciencedirect.com/science/article/pii/S0040403900012715info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:32:40Zoai:repositorium.sdum.uminho.pt:1822/72912Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:28:03.153229Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Synthesis of novel beta-substituted alpha,beta-dehydroamino acid derivatives
title Synthesis of novel beta-substituted alpha,beta-dehydroamino acid derivatives
spellingShingle Synthesis of novel beta-substituted alpha,beta-dehydroamino acid derivatives
Ferreira, Paula M. T.
alpha,beta-dehydroamino acids
beta-substituted alanines
beta-substituted alpha,beta-dehydroamino acids
α,β-Dehydroamino acids
β-Substituted alanines
β-Substituted α,β-dehydroamino acids
Science & Technology
title_short Synthesis of novel beta-substituted alpha,beta-dehydroamino acid derivatives
title_full Synthesis of novel beta-substituted alpha,beta-dehydroamino acid derivatives
title_fullStr Synthesis of novel beta-substituted alpha,beta-dehydroamino acid derivatives
title_full_unstemmed Synthesis of novel beta-substituted alpha,beta-dehydroamino acid derivatives
title_sort Synthesis of novel beta-substituted alpha,beta-dehydroamino acid derivatives
author Ferreira, Paula M. T.
author_facet Ferreira, Paula M. T.
Maia, Hernâni Lopes Silva
Monteiro, Luís S.
Sacramento, Joana
author_role author
author2 Maia, Hernâni Lopes Silva
Monteiro, Luís S.
Sacramento, Joana
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Ferreira, Paula M. T.
Maia, Hernâni Lopes Silva
Monteiro, Luís S.
Sacramento, Joana
dc.subject.por.fl_str_mv alpha,beta-dehydroamino acids
beta-substituted alanines
beta-substituted alpha,beta-dehydroamino acids
α,β-Dehydroamino acids
β-Substituted alanines
β-Substituted α,β-dehydroamino acids
Science & Technology
topic alpha,beta-dehydroamino acids
beta-substituted alanines
beta-substituted alpha,beta-dehydroamino acids
α,β-Dehydroamino acids
β-Substituted alanines
β-Substituted α,β-dehydroamino acids
Science & Technology
description beta-Substituted alpha,beta-dehydroamino acids are synthesised in high yields by a Michael addition of heterocyclic nucleophiles to the methyl esters of N-tert-butyloxycarbonyl,N-(4-toluenesulfonyl)dehydroamino acids, followed by a base-induced elimination of the 4-toluenesulfonyl group with regeneration of the alpha,beta-double bond.
publishDate 2000
dc.date.none.fl_str_mv 2000
2000-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/72912
url http://hdl.handle.net/1822/72912
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0040-4039
10.1016/S0040-4039(00)01271-5
https://www.sciencedirect.com/science/article/pii/S0040403900012715
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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