Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2819 |
Resumo: | Gait speed often referred as the sixth vital sign is the most powerful biomarker of mobility. While a clinical setting allows the estimation of gait speed under controlled conditions that present functional capacity, gait speed in real-life conditions provides the actual performance of the patient. The goal of this study was to investigate objectively under what conditions during daily activities, patients perform as well as or better than in the clinic. To this end, we recruited 27 Parkinson's disease (PD) patients and measured their gait speed by inertial measurement units through several walking tests in the clinic as well as their daily activities at home. By fitting a bimodal Gaussian model to their gait speed distribution, we found that on average, patients had similar modes in the clinic and during daily activities. Furthermore, we observed that the number of medication doses taken throughout the day had a moderate correlation with the difference between clinic and home. Performing a cycle-by-cycle analysis on gait speed during the home assessment, overall only about 3% of the strides had equal or greater gait speeds than the patients' capacity in the clinic. These strides were during long walking bouts (>1 min) and happened before noon, around 26 min after medication intake, reaching their maximum occurrence probability 3 h after Levodopa intake. These results open the possibility of better control of medication intake in PD by considering both functional capacity and continuous monitoring of gait speed during real-life conditions. |
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Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacityGait speed often referred as the sixth vital sign is the most powerful biomarker of mobility. While a clinical setting allows the estimation of gait speed under controlled conditions that present functional capacity, gait speed in real-life conditions provides the actual performance of the patient. The goal of this study was to investigate objectively under what conditions during daily activities, patients perform as well as or better than in the clinic. To this end, we recruited 27 Parkinson's disease (PD) patients and measured their gait speed by inertial measurement units through several walking tests in the clinic as well as their daily activities at home. By fitting a bimodal Gaussian model to their gait speed distribution, we found that on average, patients had similar modes in the clinic and during daily activities. Furthermore, we observed that the number of medication doses taken throughout the day had a moderate correlation with the difference between clinic and home. Performing a cycle-by-cycle analysis on gait speed during the home assessment, overall only about 3% of the strides had equal or greater gait speeds than the patients' capacity in the clinic. These strides were during long walking bouts (>1 min) and happened before noon, around 26 min after medication intake, reaching their maximum occurrence probability 3 h after Levodopa intake. These results open the possibility of better control of medication intake in PD by considering both functional capacity and continuous monitoring of gait speed during real-life conditions.Nature Publishing GroupRepositório Científico do Centro Hospitalar Universitário de Santo AntónioAtrsaei, ArashCorrà, MartaDadashi, FarzinVila Cha, NunoMaia, LuisMariani, BenoitMaetzler, WalterAminian, Kamiar2023-10-17T13:07:29Z2021-032021-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2819engAtrsaei A, Corrà MF, Dadashi F, et al. Gait speed in clinical and daily living assessments in Parkinson's disease patients: performance versus capacity. NPJ Parkinsons Dis. 2021;7(1):24. Published 2021 Mar 5. doi:10.1038/s41531-021-00171-02373-805710.1038/s41531-021-00171-0info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T11:02:40Zoai:repositorio.chporto.pt:10400.16/2819Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:59.633001Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity |
title |
Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity |
spellingShingle |
Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity Atrsaei, Arash |
title_short |
Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity |
title_full |
Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity |
title_fullStr |
Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity |
title_full_unstemmed |
Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity |
title_sort |
Gait speed in clinical and daily living assessments in Parkinson’s disease patients: performance versus capacity |
author |
Atrsaei, Arash |
author_facet |
Atrsaei, Arash Corrà, Marta Dadashi, Farzin Vila Cha, Nuno Maia, Luis Mariani, Benoit Maetzler, Walter Aminian, Kamiar |
author_role |
author |
author2 |
Corrà, Marta Dadashi, Farzin Vila Cha, Nuno Maia, Luis Mariani, Benoit Maetzler, Walter Aminian, Kamiar |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Atrsaei, Arash Corrà, Marta Dadashi, Farzin Vila Cha, Nuno Maia, Luis Mariani, Benoit Maetzler, Walter Aminian, Kamiar |
description |
Gait speed often referred as the sixth vital sign is the most powerful biomarker of mobility. While a clinical setting allows the estimation of gait speed under controlled conditions that present functional capacity, gait speed in real-life conditions provides the actual performance of the patient. The goal of this study was to investigate objectively under what conditions during daily activities, patients perform as well as or better than in the clinic. To this end, we recruited 27 Parkinson's disease (PD) patients and measured their gait speed by inertial measurement units through several walking tests in the clinic as well as their daily activities at home. By fitting a bimodal Gaussian model to their gait speed distribution, we found that on average, patients had similar modes in the clinic and during daily activities. Furthermore, we observed that the number of medication doses taken throughout the day had a moderate correlation with the difference between clinic and home. Performing a cycle-by-cycle analysis on gait speed during the home assessment, overall only about 3% of the strides had equal or greater gait speeds than the patients' capacity in the clinic. These strides were during long walking bouts (>1 min) and happened before noon, around 26 min after medication intake, reaching their maximum occurrence probability 3 h after Levodopa intake. These results open the possibility of better control of medication intake in PD by considering both functional capacity and continuous monitoring of gait speed during real-life conditions. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-03 2021-03-01T00:00:00Z 2023-10-17T13:07:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2819 |
url |
http://hdl.handle.net/10400.16/2819 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Atrsaei A, Corrà MF, Dadashi F, et al. Gait speed in clinical and daily living assessments in Parkinson's disease patients: performance versus capacity. NPJ Parkinsons Dis. 2021;7(1):24. Published 2021 Mar 5. doi:10.1038/s41531-021-00171-0 2373-8057 10.1038/s41531-021-00171-0 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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