Polymeric nanogels as vaccine delivery systems

Detalhes bibliográficos
Autor(a) principal: Ferreira, Sílvia A.
Data de Publicação: 2013
Outros Autores: Gama, F. M., Vilanova, Manuel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/24288
Resumo: Polymeric nanogels find a relevant field of application in the formulation of a new generation of therapeutic and preventive vaccines, aiming at the fine-tuned modulation of the immune response. Intrinsic properties of polymeric nanogels, such as material chemistry, size and shape, surface charge, and hydrophobicity or hydrophilicity, may be determining factors in shaping the induced immune response. These materials can thus work as synthetic adjuvants, which can also be conjugated with immunostimulants. Polymeric nanogels protect vaccine antigens from degradation in vivo and, surface-conjugated with antibodies or specific ligands, could increase active targeting specificity. This review covers the recent published data concerning the modulation of innate and adaptive immune responses by engineered polymeric nanogels and their potential application as delivery systems in vaccination.
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spelling Polymeric nanogels as vaccine delivery systemsAdjuvantsDelivery systemsPolymeric nanogelsVaccinesScience & TechnologyPolymeric nanogels find a relevant field of application in the formulation of a new generation of therapeutic and preventive vaccines, aiming at the fine-tuned modulation of the immune response. Intrinsic properties of polymeric nanogels, such as material chemistry, size and shape, surface charge, and hydrophobicity or hydrophilicity, may be determining factors in shaping the induced immune response. These materials can thus work as synthetic adjuvants, which can also be conjugated with immunostimulants. Polymeric nanogels protect vaccine antigens from degradation in vivo and, surface-conjugated with antibodies or specific ligands, could increase active targeting specificity. This review covers the recent published data concerning the modulation of innate and adaptive immune responses by engineered polymeric nanogels and their potential application as delivery systems in vaccination.S.A. Ferreira is the recipient of a fellowship from International Iberian Nanotechnology Laboratory (INL).ElsevierElsevier BVUniversidade do MinhoFerreira, Sílvia A.Gama, F. M.Vilanova, Manuel20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/24288eng1549-96341549-964210.1016/j.nano.2012.06.00122772049info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:22:10Zoai:repositorium.sdum.uminho.pt:1822/24288Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:15:37.639254Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Polymeric nanogels as vaccine delivery systems
title Polymeric nanogels as vaccine delivery systems
spellingShingle Polymeric nanogels as vaccine delivery systems
Ferreira, Sílvia A.
Adjuvants
Delivery systems
Polymeric nanogels
Vaccines
Science & Technology
title_short Polymeric nanogels as vaccine delivery systems
title_full Polymeric nanogels as vaccine delivery systems
title_fullStr Polymeric nanogels as vaccine delivery systems
title_full_unstemmed Polymeric nanogels as vaccine delivery systems
title_sort Polymeric nanogels as vaccine delivery systems
author Ferreira, Sílvia A.
author_facet Ferreira, Sílvia A.
Gama, F. M.
Vilanova, Manuel
author_role author
author2 Gama, F. M.
Vilanova, Manuel
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Ferreira, Sílvia A.
Gama, F. M.
Vilanova, Manuel
dc.subject.por.fl_str_mv Adjuvants
Delivery systems
Polymeric nanogels
Vaccines
Science & Technology
topic Adjuvants
Delivery systems
Polymeric nanogels
Vaccines
Science & Technology
description Polymeric nanogels find a relevant field of application in the formulation of a new generation of therapeutic and preventive vaccines, aiming at the fine-tuned modulation of the immune response. Intrinsic properties of polymeric nanogels, such as material chemistry, size and shape, surface charge, and hydrophobicity or hydrophilicity, may be determining factors in shaping the induced immune response. These materials can thus work as synthetic adjuvants, which can also be conjugated with immunostimulants. Polymeric nanogels protect vaccine antigens from degradation in vivo and, surface-conjugated with antibodies or specific ligands, could increase active targeting specificity. This review covers the recent published data concerning the modulation of innate and adaptive immune responses by engineered polymeric nanogels and their potential application as delivery systems in vaccination.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/24288
url http://hdl.handle.net/1822/24288
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1549-9634
1549-9642
10.1016/j.nano.2012.06.001
22772049
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
Elsevier BV
publisher.none.fl_str_mv Elsevier
Elsevier BV
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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