Can 11C-PiB-PET relative delivery R1 or 11C-PiB-PET perfusion replace 18F-FDG-PET in the assessment of brain neurodegeneration?
| Autor(a) principal: | |
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| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/36409 |
Resumo: | © 2018 – IOS Press and the authors. All rights reserved. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0). |
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Can 11C-PiB-PET relative delivery R1 or 11C-PiB-PET perfusion replace 18F-FDG-PET in the assessment of brain neurodegeneration?Alzheimer’s disease11C-PIB, compartmental models18F-FDG, neurodegenerationPerfusion© 2018 – IOS Press and the authors. All rights reserved. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).Background: Pittsburgh Compound B (PiB) positron emission tomography (PET) is used to visualize in vivo amyloid plaques in the brain. Frequently the PiB examinations are complemented with a fluorodeoxyglucose (FDG) PET scan to further assess neurodegeneration. Objective: Our goal is to identify alternative correlates of FDG images by assessing which kinetic methods originate PiB derived relative delivery ratio (R1) images that can be correlated with the FDG images, and to compare them with PiB perfusion (pPiB) images obtained from the early-phase of PiB acquisition. Methods: We selected 52 patients with cognitive impairment who underwent a dynamic PiB and FDG acquisitions. To compute the R1 images, two simplified reference tissue models (SRTM and SRTM2) and two multi-linear reference tissue models (MRTM and MRTM2) were used. The pPiB images were obtained in two different time intervals. Results: All six types of images were of good quality and highly correlated with the FDG images (mean voxelwise withinsubjects r > 0.92). The higher correlation was found for FDG-R1(MRTM). Regarding the voxelwise regional correlation, the higher mean all brain correlations was r = 0.825 for FDG-R1(MRTM) and statistically significant in the whole brain analysis. Conclusion: All R1 and pPiB images here tested have potential to assess the metabolic impact of neurodegeneration almost as reliably as the FDG images. However, this is not enough to validate these images for a single-subject analysis compared with the FDG image, and thus they cannot yet be used clinically to replace the FDG image before such evaluation.This work was supported by the following grants: Strategic project FCT-UID/NEU/04539/ 2013 – COMPETE, POCI-01-0145-FEDER-007440, BIGDATIMAGE, CENTRO-01-0145-FEDER000016, Centro 2020 FEDER, COMPETE, PAC – MEDPERSYST, POCI-01- 0145-FEDER-016428. Authors’ disclosures available online (https:// www.j-alz.com/manuscript-disclosures/18-027 4r2).IOS PressRepositório da Universidade de LisboaOliveira, Francisco P.M.Moreira, Ana PaulaDe Mendonça, AlexandreVerdelho, AnaXavier, CarolinaBarroca, DalilaRio, JoanaCardoso, EvaCruz, ÂngelaAbrunhosa, AnteroCastelo-Branco, Miguel2019-01-15T12:47:23Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/36409engJournal of Alzheimer’s Disease 65 (2018) 89–971875-890810.3233/JAD-180274info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:33:03Zoai:repositorio.ul.pt:10451/36409Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:50:41.344431Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Can 11C-PiB-PET relative delivery R1 or 11C-PiB-PET perfusion replace 18F-FDG-PET in the assessment of brain neurodegeneration? |
| title |
Can 11C-PiB-PET relative delivery R1 or 11C-PiB-PET perfusion replace 18F-FDG-PET in the assessment of brain neurodegeneration? |
| spellingShingle |
Can 11C-PiB-PET relative delivery R1 or 11C-PiB-PET perfusion replace 18F-FDG-PET in the assessment of brain neurodegeneration? Oliveira, Francisco P.M. Alzheimer’s disease 11C-PIB, compartmental models 18F-FDG, neurodegeneration Perfusion |
| title_short |
Can 11C-PiB-PET relative delivery R1 or 11C-PiB-PET perfusion replace 18F-FDG-PET in the assessment of brain neurodegeneration? |
| title_full |
Can 11C-PiB-PET relative delivery R1 or 11C-PiB-PET perfusion replace 18F-FDG-PET in the assessment of brain neurodegeneration? |
| title_fullStr |
Can 11C-PiB-PET relative delivery R1 or 11C-PiB-PET perfusion replace 18F-FDG-PET in the assessment of brain neurodegeneration? |
| title_full_unstemmed |
Can 11C-PiB-PET relative delivery R1 or 11C-PiB-PET perfusion replace 18F-FDG-PET in the assessment of brain neurodegeneration? |
| title_sort |
Can 11C-PiB-PET relative delivery R1 or 11C-PiB-PET perfusion replace 18F-FDG-PET in the assessment of brain neurodegeneration? |
| author |
Oliveira, Francisco P.M. |
| author_facet |
Oliveira, Francisco P.M. Moreira, Ana Paula De Mendonça, Alexandre Verdelho, Ana Xavier, Carolina Barroca, Dalila Rio, Joana Cardoso, Eva Cruz, Ângela Abrunhosa, Antero Castelo-Branco, Miguel |
| author_role |
author |
| author2 |
Moreira, Ana Paula De Mendonça, Alexandre Verdelho, Ana Xavier, Carolina Barroca, Dalila Rio, Joana Cardoso, Eva Cruz, Ângela Abrunhosa, Antero Castelo-Branco, Miguel |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Oliveira, Francisco P.M. Moreira, Ana Paula De Mendonça, Alexandre Verdelho, Ana Xavier, Carolina Barroca, Dalila Rio, Joana Cardoso, Eva Cruz, Ângela Abrunhosa, Antero Castelo-Branco, Miguel |
| dc.subject.por.fl_str_mv |
Alzheimer’s disease 11C-PIB, compartmental models 18F-FDG, neurodegeneration Perfusion |
| topic |
Alzheimer’s disease 11C-PIB, compartmental models 18F-FDG, neurodegeneration Perfusion |
| description |
© 2018 – IOS Press and the authors. All rights reserved. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0). |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2019-01-15T12:47:23Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/36409 |
| url |
http://hdl.handle.net/10451/36409 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Journal of Alzheimer’s Disease 65 (2018) 89–97 1875-8908 10.3233/JAD-180274 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
IOS Press |
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IOS Press |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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