Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/54853 |
Resumo: | © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retinaAngiogenesisCell polarityMechanobiologyMorphogenesisShear stress© 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Blood-vessel formation generates unique vascular patterns in each individual. The principles governing the apparent stochasticity of this process remain to be elucidated. Using mathematical methods, we find that the transition between two fundamental vascular morphogenetic programs-sprouting angiogenesis and vascular remodeling-is established by a shift of collective front-to-rear polarity of endothelial cells in the mouse retina. We demonstrate that the competition between biochemical (VEGFA) and mechanical (blood-flow-induced shear stress) cues controls this collective polarity shift. Shear stress increases tension at focal adhesions overriding VEGFA-driven collective polarization, which relies on tension at adherens junctions. We propose that vascular morphogenetic cues compete to regulate individual cell polarity and migration through tension shifts that translates into tissue-level emergent behaviors, ultimately leading to uniquely organized vascular patterns.Funding: European Research Council: C.A.F. (679368); X.T. (883739). European Commission: C.A.F. and M.O.B. (801423); X.T. and P.R.-C. (731957). H2020-MSCA-PF grants to M.G.-G. (797621) and M.O. (842498). Fondation LeDucq: C.A.F., A.E., and M.O.B. (17CVD03). EPSRC: M.O.B. (EP/T008806/1; EP/R029598/1). Fundação para a Ciência e Tecnologia: C.A.F. (PTDC/MED-PAT/31639/2017; PTDC/BIA-CEL/32180/2017; CEECIND/04251/2017). Spanish Ministry of Science and Innovation: P.R.-C. (PID2019-110298GB-I00); X.T. (PGC2018-099645-B-I00). Generalitat de Catalunya: X.T. and P.R.-C. (2017-SGR-1602). La Caixa Foundation: X.T. and P.R.-C. (LCF/PR/HR20/52400004). Fundació la Marató de TV3: X.T. (201903-30-31-32). EMBO: L.M.F. (ALTF 2-2018)ElsevierRepositório da Universidade de LisboaBarbacena, PedroDominguez-Cejudo, Maria AngelesFonseca, CatarinaGómez-González, ManuelFaure, Laura M.Zarkada, GeorgiaPena, AndreiaPezzarossa, AnnaRamalho, DanielaGiarratano, YleniaOuarné, MarieBarata, DavidFortunato, Isabela C.Henao Mišíková, LenkaMauldin, IanCarvalho, YuliaTrepat, XavierRoca-Cusachs, PereEichmann, AnneBernabeu, Miguel O.Franco, Claudio2022-10-21T15:26:10Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54853engDev Cell. 2022 Oct 10;57(19):2321-2333.e91534-580710.1016/j.devcel.2022.09.0021878-1551info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:01:32Zoai:repositorio.ul.pt:10451/54853Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:37.985068Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina |
| title |
Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina |
| spellingShingle |
Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina Barbacena, Pedro Angiogenesis Cell polarity Mechanobiology Morphogenesis Shear stress |
| title_short |
Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina |
| title_full |
Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina |
| title_fullStr |
Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina |
| title_full_unstemmed |
Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina |
| title_sort |
Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina |
| author |
Barbacena, Pedro |
| author_facet |
Barbacena, Pedro Dominguez-Cejudo, Maria Angeles Fonseca, Catarina Gómez-González, Manuel Faure, Laura M. Zarkada, Georgia Pena, Andreia Pezzarossa, Anna Ramalho, Daniela Giarratano, Ylenia Ouarné, Marie Barata, David Fortunato, Isabela C. Henao Mišíková, Lenka Mauldin, Ian Carvalho, Yulia Trepat, Xavier Roca-Cusachs, Pere Eichmann, Anne Bernabeu, Miguel O. Franco, Claudio |
| author_role |
author |
| author2 |
Dominguez-Cejudo, Maria Angeles Fonseca, Catarina Gómez-González, Manuel Faure, Laura M. Zarkada, Georgia Pena, Andreia Pezzarossa, Anna Ramalho, Daniela Giarratano, Ylenia Ouarné, Marie Barata, David Fortunato, Isabela C. Henao Mišíková, Lenka Mauldin, Ian Carvalho, Yulia Trepat, Xavier Roca-Cusachs, Pere Eichmann, Anne Bernabeu, Miguel O. Franco, Claudio |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Barbacena, Pedro Dominguez-Cejudo, Maria Angeles Fonseca, Catarina Gómez-González, Manuel Faure, Laura M. Zarkada, Georgia Pena, Andreia Pezzarossa, Anna Ramalho, Daniela Giarratano, Ylenia Ouarné, Marie Barata, David Fortunato, Isabela C. Henao Mišíková, Lenka Mauldin, Ian Carvalho, Yulia Trepat, Xavier Roca-Cusachs, Pere Eichmann, Anne Bernabeu, Miguel O. Franco, Claudio |
| dc.subject.por.fl_str_mv |
Angiogenesis Cell polarity Mechanobiology Morphogenesis Shear stress |
| topic |
Angiogenesis Cell polarity Mechanobiology Morphogenesis Shear stress |
| description |
© 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-10-21T15:26:10Z 2022 2022-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/54853 |
| url |
http://hdl.handle.net/10451/54853 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Dev Cell. 2022 Oct 10;57(19):2321-2333.e9 1534-5807 10.1016/j.devcel.2022.09.002 1878-1551 |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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