In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.6/13834 |
Resumo: | Gold-based nanoparticles present excellent optical properties that propelled their widespread application in biomedicine, from bioimaging to photothermal applications. Nevertheless, commonly employed manufacturing methods for gold-based nanoparticles require long periods and laborious protocols that reduce cost-effectiveness and scalability. Herein, a novel methodology was used for producing gold-alginic acid nanohybrids (Au-Alg-NH) with photothermal capabilities. This was accomplished by promoting the in situ reduction and nucleation of gold ions throughout a matrix of alginic acid by using ascorbic acid. The results obtained reveal that the Au-Alg-NHs present a uniform size distribution and a spike-like shape. Moreover, the nanomaterials were capable to mediate a temperature increase of ≈11°C in response to the irradiation with a near-infrared region (NIR) laser (808 nm, 1.7 W cm−2). The in vitro assays showed that Au-Alg-NHs were able to perform a NIR light-triggered ablation of cancer cells (MCF-7), being observed a reduction in the cell viability to ≈27%. Therefore, the results demonstrate that this novel methodology holds the potential for producing Au-Alg-NH with photothermal capacity and higher translatability to the clinical practice, namely for cancer therapy. |
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In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapyPhototermal therapyGold nanohybridsCancerAlginic acidGold-based nanoparticles present excellent optical properties that propelled their widespread application in biomedicine, from bioimaging to photothermal applications. Nevertheless, commonly employed manufacturing methods for gold-based nanoparticles require long periods and laborious protocols that reduce cost-effectiveness and scalability. Herein, a novel methodology was used for producing gold-alginic acid nanohybrids (Au-Alg-NH) with photothermal capabilities. This was accomplished by promoting the in situ reduction and nucleation of gold ions throughout a matrix of alginic acid by using ascorbic acid. The results obtained reveal that the Au-Alg-NHs present a uniform size distribution and a spike-like shape. Moreover, the nanomaterials were capable to mediate a temperature increase of ≈11°C in response to the irradiation with a near-infrared region (NIR) laser (808 nm, 1.7 W cm−2). The in vitro assays showed that Au-Alg-NHs were able to perform a NIR light-triggered ablation of cancer cells (MCF-7), being observed a reduction in the cell viability to ≈27%. Therefore, the results demonstrate that this novel methodology holds the potential for producing Au-Alg-NH with photothermal capacity and higher translatability to the clinical practice, namely for cancer therapy.Foundation for Science and Technology, Grant/Award Numbers: SFRH/BD/144680/2019,2022.14608.BD,UIDB/00709/2020;EuropeanRegionalDevelopmentFund,Grant/AwardNumbers:CENTRO-01-0145-FEDER-028989,POCI-01-0145-FEDER-031462WileyuBibliorumFigueiredo, André Q.Rodrigues, Ana Carolina FélixFernandes, NatanaelCorreia, I.J.Moreira, André F.2023-09-082026-12-18T00:00:00Z2023-09-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/13834eng10.1002/biot.202300019info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-20T02:30:43Zoai:ubibliorum.ubi.pt:10400.6/13834Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:55:18.081259Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy |
title |
In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy |
spellingShingle |
In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy Figueiredo, André Q. Phototermal therapy Gold nanohybrids Cancer Alginic acid |
title_short |
In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy |
title_full |
In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy |
title_fullStr |
In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy |
title_full_unstemmed |
In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy |
title_sort |
In situ formation of alginic acid‐gold nanohybrids for application in cancer photothermal therapy |
author |
Figueiredo, André Q. |
author_facet |
Figueiredo, André Q. Rodrigues, Ana Carolina Félix Fernandes, Natanael Correia, I.J. Moreira, André F. |
author_role |
author |
author2 |
Rodrigues, Ana Carolina Félix Fernandes, Natanael Correia, I.J. Moreira, André F. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
uBibliorum |
dc.contributor.author.fl_str_mv |
Figueiredo, André Q. Rodrigues, Ana Carolina Félix Fernandes, Natanael Correia, I.J. Moreira, André F. |
dc.subject.por.fl_str_mv |
Phototermal therapy Gold nanohybrids Cancer Alginic acid |
topic |
Phototermal therapy Gold nanohybrids Cancer Alginic acid |
description |
Gold-based nanoparticles present excellent optical properties that propelled their widespread application in biomedicine, from bioimaging to photothermal applications. Nevertheless, commonly employed manufacturing methods for gold-based nanoparticles require long periods and laborious protocols that reduce cost-effectiveness and scalability. Herein, a novel methodology was used for producing gold-alginic acid nanohybrids (Au-Alg-NH) with photothermal capabilities. This was accomplished by promoting the in situ reduction and nucleation of gold ions throughout a matrix of alginic acid by using ascorbic acid. The results obtained reveal that the Au-Alg-NHs present a uniform size distribution and a spike-like shape. Moreover, the nanomaterials were capable to mediate a temperature increase of ≈11°C in response to the irradiation with a near-infrared region (NIR) laser (808 nm, 1.7 W cm−2). The in vitro assays showed that Au-Alg-NHs were able to perform a NIR light-triggered ablation of cancer cells (MCF-7), being observed a reduction in the cell viability to ≈27%. Therefore, the results demonstrate that this novel methodology holds the potential for producing Au-Alg-NH with photothermal capacity and higher translatability to the clinical practice, namely for cancer therapy. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-09-08 2023-09-08T00:00:00Z 2026-12-18T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/13834 |
url |
http://hdl.handle.net/10400.6/13834 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1002/biot.202300019 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
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embargoedAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136439482449920 |