Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/57349 |
Resumo: | © 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
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Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesisIL-33Toll-like receptorsAsthmaMultimorbidityRhinitis© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.WileyRepositório da Universidade de LisboaBousquet, J.Melén, E.Haahtela, T.Koppelman, G. H.Togias, A.Valenta, R.Akdis, C. A.Czarlewski, W.Rothenberg, M.Valiulis, A.Wickman, M.Akdis, M.Aguilar, D.Bedbrook, A.Bindslev‐Jensen, C.Bosnic‐Anticevich, S.Boulet, L. P.Brightling, C. E.Brussino, L.Burte, E.Bustamante, M.Canonica, G. W.Cecchi, L.Celedon, J. C.Chaves Loureiro, C.Costa, E.Cruz, A. A.Erhola, M.Gemicioglu, B.Fokkens, W. J.Garcia‐Aymerich, J.Guerra, S.Heinrich, J.Ivancevich, J. C.Keil, T.Klimek, L.Kuna, P.Kupczyk, M.Kvedariene, V.Larenas‐Linnemann, D. E.Lemonnier, N.Lodrup Carlsen, K. C.Louis, R.Makela, M.Makris, M.Maurer, M.Momas, I.Morais‐Almeida, M.Mullol, J.Naclerio, R. N.Nadeau, K.Nadif, R.Niedoszytko, M.Okamoto, Y.Ollert, M.Papadopoulos, N. G.Passalacqua, G.Patella, V.Pawankar, R.Pham‐Thi, N.Pfaar, O.Regateiro, F. S.Ring, J.Rouadi, P. W.Samolinski, B.Sastre, J.Savouré, M.Scichilone, N.Shamji, M. H.Sheikh, A.Siroux, V.Sousa‐Pinto, B.Standl, M.Sunyer, J.Taborda‐Barata, L.Toppila‐Salmi, S.Torres, M. J.Tsiligianni, I.Valovirta, E.Vandenplas, O.Ventura, M. T.Weiss, S.Yorgancioglu, A.Zhang, L.Abdul Latiff, A. H.Aberer, W.Agache, I.Al‐Ahmad, M.Alobid, I.Ansotegui, I. J.Arshad, S. H.Asayag, E.Bárbara, CristinaBaharudin, A.Battur, L.Bennoor, K. S.Berghea, E. C.Bergmann, K. C.Bernstein, D.Bewick, M.Blain, H.Bonini, M.Braido, F.Buhl, R.Bumbacea, R. S.Bush, A.Calderon, M.Calvo‐Gil, M.Camargos, P.Caraballo, L.Cardona, V.Carr, W.Carreiro‐Martins, P.Casale, T.Cepeda Sarabia, A. M.Chandrasekharan, R.Charpin, D.Chen, Y. Z.Cherrez‐Ojeda, I.Chivato, T.Chkhartishvili, E.Christoff, G.Chu, D. K.Cingi, C.Correia de Sousa, J.Corrigan, C.Custovic, A.D’Amato, G.Del Giacco, S.De Blay, F.Devillier, P.Didier, A.do Ceu Teixeira, M.Dokic, D.Douagui, H.Doulaptsi, M.Durham, S.Dykewicz, M.Eiwegger, T.El‐Sayed, Z. A.Emuzyte, R.Fiocchi, A.Fyhrquist, N.Gomez, R. M.Gotua, M.Guzman, M. A.Hagemann, J.Hamamah, S.Halken, S.Halpin, D. M. G.Hofmann, M.Hossny, E.Hrubiško, M.Irani, C.Ispayeva, Z.Jares, E.Jartti, T.Jassem, E.Julge, K.Just, J.Jutel, M.Kaidashev, I.Kalayci, O.Kalyoncu, A. F.Kardas, P.Kirenga, B.Kraxner, H.Kull, I.Kulus, M.La Grutta, S.Lau, S.Le Tuyet Thi, L.Levin, M.Lipworth, B.Lourenço, O.Mahboub, B.Martinez‐Infante, E.Matricardi, P.Miculinic, N.Migueres, N.Mihaltan, F.Mohammad, Y.Moniuszko, M.Montefort, S.Neffen, H.Nekam, K.Nunes, E.Nyembue Tshipukane, D.O’Hehir, R.Ogulur, I.Ohta, K.Okubo, K.Ouedraogo, S.Olze, H.Pali‐Schöll, I.Palomares, O.Palosuo, K.Panaitescu, C.Panzner, P.Park, H. S.Pitsios, C.Plavec, D.Popov, T. A.Puggioni, F.Quirce, S.Recto, M.Repka‐Ramirez, M. S.Robalo Cordeiro, C.Roche, N.Rodriguez‐Gonzalez, M.Romantowski, J.Rosario Filho, N.Rottem, M.Sagara, H.Serpa, F. S.Sayah, Z.Scheire, S.Schmid‐Grendelmeier, P.Sisul, J. C.Sole, D.Soto‐Martinez, M.Sova, M.Sperl, A.Spranger, O.Stelmach, R.Suppli Ulrik, C.Thomas, M.To, T.Todo‐Bom, A.Tomazic, P. V.Urrutia‐Pereira, M.Valentin‐Rostan, M.Van Ganse, E.van Hage, M.Vasankari, T.Vichyanond, P.Viegi, G.Wallace, D.Wang, D. Y.Williams, S.Worm, M.Yiallouros, P.Yusuf, O.Zaitoun, F.Zernotti, M.Zidarn, M.Zuberbier, J.Fonseca, J. A.Zuberbier, T.Anto, J. M.2023-05-04T13:37:46Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57349engAllergy. 2023 May;78(5):1169-12030105-453810.1111/all.156791398-9995info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:05:31Zoai:repositorio.ul.pt:10451/57349Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:46.414290Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis |
title |
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis |
spellingShingle |
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis Bousquet, J. IL-33 Toll-like receptors Asthma Multimorbidity Rhinitis |
title_short |
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis |
title_full |
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis |
title_fullStr |
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis |
title_full_unstemmed |
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis |
title_sort |
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis |
author |
Bousquet, J. |
author_facet |
Bousquet, J. Melén, E. Haahtela, T. Koppelman, G. H. Togias, A. Valenta, R. Akdis, C. A. Czarlewski, W. Rothenberg, M. Valiulis, A. Wickman, M. Akdis, M. Aguilar, D. Bedbrook, A. Bindslev‐Jensen, C. Bosnic‐Anticevich, S. Boulet, L. P. Brightling, C. E. Brussino, L. Burte, E. Bustamante, M. Canonica, G. W. Cecchi, L. Celedon, J. C. Chaves Loureiro, C. Costa, E. Cruz, A. A. Erhola, M. Gemicioglu, B. Fokkens, W. J. Garcia‐Aymerich, J. Guerra, S. Heinrich, J. Ivancevich, J. C. Keil, T. Klimek, L. Kuna, P. Kupczyk, M. Kvedariene, V. Larenas‐Linnemann, D. E. Lemonnier, N. Lodrup Carlsen, K. C. Louis, R. Makela, M. Makris, M. Maurer, M. Momas, I. Morais‐Almeida, M. Mullol, J. Naclerio, R. N. Nadeau, K. Nadif, R. Niedoszytko, M. Okamoto, Y. Ollert, M. Papadopoulos, N. G. Passalacqua, G. Patella, V. Pawankar, R. Pham‐Thi, N. Pfaar, O. Regateiro, F. S. Ring, J. Rouadi, P. W. Samolinski, B. Sastre, J. Savouré, M. Scichilone, N. Shamji, M. H. Sheikh, A. Siroux, V. Sousa‐Pinto, B. Standl, M. Sunyer, J. Taborda‐Barata, L. Toppila‐Salmi, S. Torres, M. J. Tsiligianni, I. Valovirta, E. Vandenplas, O. Ventura, M. T. Weiss, S. Yorgancioglu, A. Zhang, L. Abdul Latiff, A. H. Aberer, W. Agache, I. Al‐Ahmad, M. Alobid, I. Ansotegui, I. J. Arshad, S. H. Asayag, E. Bárbara, Cristina Baharudin, A. Battur, L. Bennoor, K. S. Berghea, E. C. Bergmann, K. C. Bernstein, D. Bewick, M. Blain, H. Bonini, M. Braido, F. Buhl, R. Bumbacea, R. S. Bush, A. Calderon, M. Calvo‐Gil, M. Camargos, P. Caraballo, L. Cardona, V. Carr, W. Carreiro‐Martins, P. Casale, T. Cepeda Sarabia, A. M. Chandrasekharan, R. Charpin, D. Chen, Y. Z. Cherrez‐Ojeda, I. Chivato, T. Chkhartishvili, E. Christoff, G. Chu, D. K. Cingi, C. Correia de Sousa, J. Corrigan, C. Custovic, A. D’Amato, G. Del Giacco, S. De Blay, F. Devillier, P. Didier, A. do Ceu Teixeira, M. Dokic, D. Douagui, H. Doulaptsi, M. Durham, S. Dykewicz, M. Eiwegger, T. El‐Sayed, Z. A. Emuzyte, R. Fiocchi, A. Fyhrquist, N. Gomez, R. M. Gotua, M. Guzman, M. A. Hagemann, J. Hamamah, S. Halken, S. Halpin, D. M. G. Hofmann, M. Hossny, E. Hrubiško, M. Irani, C. Ispayeva, Z. Jares, E. Jartti, T. Jassem, E. Julge, K. Just, J. Jutel, M. Kaidashev, I. Kalayci, O. Kalyoncu, A. F. Kardas, P. Kirenga, B. Kraxner, H. Kull, I. Kulus, M. La Grutta, S. Lau, S. Le Tuyet Thi, L. Levin, M. Lipworth, B. Lourenço, O. Mahboub, B. Martinez‐Infante, E. Matricardi, P. Miculinic, N. Migueres, N. Mihaltan, F. Mohammad, Y. Moniuszko, M. Montefort, S. Neffen, H. Nekam, K. Nunes, E. Nyembue Tshipukane, D. O’Hehir, R. Ogulur, I. Ohta, K. Okubo, K. Ouedraogo, S. Olze, H. Pali‐Schöll, I. Palomares, O. Palosuo, K. Panaitescu, C. Panzner, P. Park, H. S. Pitsios, C. Plavec, D. Popov, T. A. Puggioni, F. Quirce, S. Recto, M. Repka‐Ramirez, M. S. Robalo Cordeiro, C. Roche, N. Rodriguez‐Gonzalez, M. Romantowski, J. Rosario Filho, N. Rottem, M. Sagara, H. Serpa, F. S. Sayah, Z. Scheire, S. Schmid‐Grendelmeier, P. Sisul, J. C. Sole, D. Soto‐Martinez, M. Sova, M. Sperl, A. Spranger, O. Stelmach, R. Suppli Ulrik, C. Thomas, M. To, T. Todo‐Bom, A. Tomazic, P. V. Urrutia‐Pereira, M. Valentin‐Rostan, M. Van Ganse, E. van Hage, M. Vasankari, T. Vichyanond, P. Viegi, G. Wallace, D. Wang, D. Y. Williams, S. Worm, M. Yiallouros, P. Yusuf, O. Zaitoun, F. Zernotti, M. Zidarn, M. Zuberbier, J. Fonseca, J. A. Zuberbier, T. Anto, J. M. |
author_role |
author |
author2 |
Melén, E. Haahtela, T. Koppelman, G. H. Togias, A. Valenta, R. Akdis, C. A. Czarlewski, W. Rothenberg, M. Valiulis, A. Wickman, M. Akdis, M. Aguilar, D. Bedbrook, A. Bindslev‐Jensen, C. Bosnic‐Anticevich, S. Boulet, L. P. Brightling, C. E. Brussino, L. Burte, E. Bustamante, M. Canonica, G. W. Cecchi, L. Celedon, J. C. Chaves Loureiro, C. Costa, E. Cruz, A. A. Erhola, M. Gemicioglu, B. Fokkens, W. J. Garcia‐Aymerich, J. Guerra, S. Heinrich, J. Ivancevich, J. C. Keil, T. Klimek, L. Kuna, P. Kupczyk, M. Kvedariene, V. Larenas‐Linnemann, D. E. Lemonnier, N. Lodrup Carlsen, K. C. Louis, R. Makela, M. Makris, M. Maurer, M. Momas, I. Morais‐Almeida, M. Mullol, J. Naclerio, R. N. Nadeau, K. Nadif, R. Niedoszytko, M. Okamoto, Y. Ollert, M. Papadopoulos, N. G. Passalacqua, G. Patella, V. Pawankar, R. Pham‐Thi, N. Pfaar, O. Regateiro, F. S. Ring, J. Rouadi, P. W. Samolinski, B. Sastre, J. Savouré, M. Scichilone, N. Shamji, M. H. Sheikh, A. Siroux, V. Sousa‐Pinto, B. Standl, M. Sunyer, J. Taborda‐Barata, L. Toppila‐Salmi, S. Torres, M. J. Tsiligianni, I. Valovirta, E. Vandenplas, O. Ventura, M. T. Weiss, S. Yorgancioglu, A. Zhang, L. Abdul Latiff, A. H. Aberer, W. Agache, I. Al‐Ahmad, M. Alobid, I. Ansotegui, I. J. Arshad, S. H. Asayag, E. Bárbara, Cristina Baharudin, A. Battur, L. Bennoor, K. S. Berghea, E. C. Bergmann, K. C. Bernstein, D. Bewick, M. Blain, H. Bonini, M. Braido, F. Buhl, R. Bumbacea, R. S. Bush, A. Calderon, M. Calvo‐Gil, M. Camargos, P. Caraballo, L. Cardona, V. Carr, W. Carreiro‐Martins, P. Casale, T. Cepeda Sarabia, A. M. Chandrasekharan, R. Charpin, D. Chen, Y. Z. Cherrez‐Ojeda, I. Chivato, T. Chkhartishvili, E. Christoff, G. Chu, D. K. Cingi, C. Correia de Sousa, J. Corrigan, C. Custovic, A. D’Amato, G. Del Giacco, S. De Blay, F. Devillier, P. Didier, A. do Ceu Teixeira, M. Dokic, D. Douagui, H. Doulaptsi, M. Durham, S. Dykewicz, M. Eiwegger, T. El‐Sayed, Z. A. Emuzyte, R. Fiocchi, A. Fyhrquist, N. Gomez, R. M. Gotua, M. Guzman, M. A. Hagemann, J. Hamamah, S. Halken, S. Halpin, D. M. G. Hofmann, M. Hossny, E. Hrubiško, M. Irani, C. Ispayeva, Z. Jares, E. Jartti, T. Jassem, E. Julge, K. Just, J. Jutel, M. Kaidashev, I. Kalayci, O. Kalyoncu, A. F. Kardas, P. Kirenga, B. Kraxner, H. Kull, I. Kulus, M. La Grutta, S. Lau, S. Le Tuyet Thi, L. Levin, M. Lipworth, B. Lourenço, O. Mahboub, B. Martinez‐Infante, E. Matricardi, P. Miculinic, N. Migueres, N. Mihaltan, F. Mohammad, Y. Moniuszko, M. Montefort, S. Neffen, H. Nekam, K. Nunes, E. Nyembue Tshipukane, D. O’Hehir, R. Ogulur, I. Ohta, K. Okubo, K. Ouedraogo, S. Olze, H. Pali‐Schöll, I. Palomares, O. Palosuo, K. Panaitescu, C. Panzner, P. Park, H. S. Pitsios, C. Plavec, D. Popov, T. A. Puggioni, F. Quirce, S. Recto, M. Repka‐Ramirez, M. S. Robalo Cordeiro, C. Roche, N. Rodriguez‐Gonzalez, M. Romantowski, J. Rosario Filho, N. Rottem, M. Sagara, H. Serpa, F. S. Sayah, Z. Scheire, S. Schmid‐Grendelmeier, P. Sisul, J. C. Sole, D. Soto‐Martinez, M. Sova, M. Sperl, A. Spranger, O. Stelmach, R. Suppli Ulrik, C. Thomas, M. To, T. Todo‐Bom, A. Tomazic, P. V. Urrutia‐Pereira, M. Valentin‐Rostan, M. Van Ganse, E. van Hage, M. Vasankari, T. Vichyanond, P. Viegi, G. Wallace, D. Wang, D. Y. Williams, S. Worm, M. Yiallouros, P. Yusuf, O. Zaitoun, F. Zernotti, M. Zidarn, M. Zuberbier, J. Fonseca, J. A. Zuberbier, T. Anto, J. M. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Bousquet, J. Melén, E. Haahtela, T. Koppelman, G. H. Togias, A. Valenta, R. Akdis, C. A. Czarlewski, W. Rothenberg, M. Valiulis, A. Wickman, M. Akdis, M. Aguilar, D. Bedbrook, A. Bindslev‐Jensen, C. Bosnic‐Anticevich, S. Boulet, L. P. Brightling, C. E. Brussino, L. Burte, E. Bustamante, M. Canonica, G. W. Cecchi, L. Celedon, J. C. Chaves Loureiro, C. Costa, E. Cruz, A. A. Erhola, M. Gemicioglu, B. Fokkens, W. J. Garcia‐Aymerich, J. Guerra, S. Heinrich, J. Ivancevich, J. C. Keil, T. Klimek, L. Kuna, P. Kupczyk, M. Kvedariene, V. Larenas‐Linnemann, D. E. Lemonnier, N. Lodrup Carlsen, K. C. Louis, R. Makela, M. Makris, M. Maurer, M. Momas, I. Morais‐Almeida, M. Mullol, J. Naclerio, R. N. Nadeau, K. Nadif, R. Niedoszytko, M. Okamoto, Y. Ollert, M. Papadopoulos, N. G. Passalacqua, G. Patella, V. Pawankar, R. Pham‐Thi, N. Pfaar, O. Regateiro, F. S. Ring, J. Rouadi, P. W. Samolinski, B. Sastre, J. Savouré, M. Scichilone, N. Shamji, M. H. Sheikh, A. Siroux, V. Sousa‐Pinto, B. Standl, M. Sunyer, J. Taborda‐Barata, L. Toppila‐Salmi, S. Torres, M. J. Tsiligianni, I. Valovirta, E. Vandenplas, O. Ventura, M. T. Weiss, S. Yorgancioglu, A. Zhang, L. Abdul Latiff, A. H. Aberer, W. Agache, I. Al‐Ahmad, M. Alobid, I. Ansotegui, I. J. Arshad, S. H. Asayag, E. Bárbara, Cristina Baharudin, A. Battur, L. Bennoor, K. S. Berghea, E. C. Bergmann, K. C. Bernstein, D. Bewick, M. Blain, H. Bonini, M. Braido, F. Buhl, R. Bumbacea, R. S. Bush, A. Calderon, M. Calvo‐Gil, M. Camargos, P. Caraballo, L. Cardona, V. Carr, W. Carreiro‐Martins, P. Casale, T. Cepeda Sarabia, A. M. Chandrasekharan, R. Charpin, D. Chen, Y. Z. Cherrez‐Ojeda, I. Chivato, T. Chkhartishvili, E. Christoff, G. Chu, D. K. Cingi, C. Correia de Sousa, J. Corrigan, C. Custovic, A. D’Amato, G. Del Giacco, S. De Blay, F. Devillier, P. Didier, A. do Ceu Teixeira, M. Dokic, D. Douagui, H. Doulaptsi, M. Durham, S. Dykewicz, M. Eiwegger, T. El‐Sayed, Z. A. Emuzyte, R. Fiocchi, A. Fyhrquist, N. Gomez, R. M. Gotua, M. Guzman, M. A. Hagemann, J. Hamamah, S. Halken, S. Halpin, D. M. G. Hofmann, M. Hossny, E. Hrubiško, M. Irani, C. Ispayeva, Z. Jares, E. Jartti, T. Jassem, E. Julge, K. Just, J. Jutel, M. Kaidashev, I. Kalayci, O. Kalyoncu, A. F. Kardas, P. Kirenga, B. Kraxner, H. Kull, I. Kulus, M. La Grutta, S. Lau, S. Le Tuyet Thi, L. Levin, M. Lipworth, B. Lourenço, O. Mahboub, B. Martinez‐Infante, E. Matricardi, P. Miculinic, N. Migueres, N. Mihaltan, F. Mohammad, Y. Moniuszko, M. Montefort, S. Neffen, H. Nekam, K. Nunes, E. Nyembue Tshipukane, D. O’Hehir, R. Ogulur, I. Ohta, K. Okubo, K. Ouedraogo, S. Olze, H. Pali‐Schöll, I. Palomares, O. Palosuo, K. Panaitescu, C. Panzner, P. Park, H. S. Pitsios, C. Plavec, D. Popov, T. A. Puggioni, F. Quirce, S. Recto, M. Repka‐Ramirez, M. S. Robalo Cordeiro, C. Roche, N. Rodriguez‐Gonzalez, M. Romantowski, J. Rosario Filho, N. Rottem, M. Sagara, H. Serpa, F. S. Sayah, Z. Scheire, S. Schmid‐Grendelmeier, P. Sisul, J. C. Sole, D. Soto‐Martinez, M. Sova, M. Sperl, A. Spranger, O. Stelmach, R. Suppli Ulrik, C. Thomas, M. To, T. Todo‐Bom, A. Tomazic, P. V. Urrutia‐Pereira, M. Valentin‐Rostan, M. Van Ganse, E. van Hage, M. Vasankari, T. Vichyanond, P. Viegi, G. Wallace, D. Wang, D. Y. Williams, S. Worm, M. Yiallouros, P. Yusuf, O. Zaitoun, F. Zernotti, M. Zidarn, M. Zuberbier, J. Fonseca, J. A. Zuberbier, T. Anto, J. M. |
dc.subject.por.fl_str_mv |
IL-33 Toll-like receptors Asthma Multimorbidity Rhinitis |
topic |
IL-33 Toll-like receptors Asthma Multimorbidity Rhinitis |
description |
© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-05-04T13:37:46Z 2023 2023-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/57349 |
url |
http://hdl.handle.net/10451/57349 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Allergy. 2023 May;78(5):1169-1203 0105-4538 10.1111/all.15679 1398-9995 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799134631005519872 |