Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis

Detalhes bibliográficos
Autor(a) principal: Bousquet, J.
Data de Publicação: 2023
Outros Autores: Melén, E., Haahtela, T., Koppelman, G. H., Togias, A., Valenta, R., Akdis, C. A., Czarlewski, W., Rothenberg, M., Valiulis, A., Wickman, M., Akdis, M., Aguilar, D., Bedbrook, A., Bindslev‐Jensen, C., Bosnic‐Anticevich, S., Boulet, L. P., Brightling, C. E., Brussino, L., Burte, E., Bustamante, M., Canonica, G. W., Cecchi, L., Celedon, J. C., Chaves Loureiro, C., Costa, E., Cruz, A. A., Erhola, M., Gemicioglu, B., Fokkens, W. J., Garcia‐Aymerich, J., Guerra, S., Heinrich, J., Ivancevich, J. C., Keil, T., Klimek, L., Kuna, P., Kupczyk, M., Kvedariene, V., Larenas‐Linnemann, D. E., Lemonnier, N., Lodrup Carlsen, K. C., Louis, R., Makela, M., Makris, M., Maurer, M., Momas, I., Morais‐Almeida, M., Mullol, J., Naclerio, R. N., Nadeau, K., Nadif, R., Niedoszytko, M., Okamoto, Y., Ollert, M., Papadopoulos, N. G., Passalacqua, G., Patella, V., Pawankar, R., Pham‐Thi, N., Pfaar, O., Regateiro, F. S., Ring, J., Rouadi, P. W., Samolinski, B., Sastre, J., Savouré, M., Scichilone, N., Shamji, M. H., Sheikh, A., Siroux, V., Sousa‐Pinto, B., Standl, M., Sunyer, J., Taborda‐Barata, L., Toppila‐Salmi, S., Torres, M. J., Tsiligianni, I., Valovirta, E., Vandenplas, O., Ventura, M. T., Weiss, S., Yorgancioglu, A., Zhang, L., Abdul Latiff, A. H., Aberer, W., Agache, I., Al‐Ahmad, M., Alobid, I., Ansotegui, I. J., Arshad, S. H., Asayag, E., Bárbara, Cristina, Baharudin, A., Battur, L., Bennoor, K. S., Berghea, E. C., Bergmann, K. C., Bernstein, D., Bewick, M., Blain, H., Bonini, M., Braido, F., Buhl, R., Bumbacea, R. S., Bush, A., Calderon, M., Calvo‐Gil, M., Camargos, P., Caraballo, L., Cardona, V., Carr, W., Carreiro‐Martins, P., Casale, T., Cepeda Sarabia, A. M., Chandrasekharan, R., Charpin, D., Chen, Y. Z., Cherrez‐Ojeda, I., Chivato, T., Chkhartishvili, E., Christoff, G., Chu, D. K., Cingi, C., Correia de Sousa, J., Corrigan, C., Custovic, A., D’Amato, G., Del Giacco, S., De Blay, F., Devillier, P., Didier, A., do Ceu Teixeira, M., Dokic, D., Douagui, H., Doulaptsi, M., Durham, S., Dykewicz, M., Eiwegger, T., El‐Sayed, Z. A., Emuzyte, R., Fiocchi, A., Fyhrquist, N., Gomez, R. M., Gotua, M., Guzman, M. A., Hagemann, J., Hamamah, S., Halken, S., Halpin, D. M. G., Hofmann, M., Hossny, E., Hrubiško, M., Irani, C., Ispayeva, Z., Jares, E., Jartti, T., Jassem, E., Julge, K., Just, J., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Kardas, P., Kirenga, B., Kraxner, H., Kull, I., Kulus, M., La Grutta, S., Lau, S., Le Tuyet Thi, L., Levin, M., Lipworth, B., Lourenço, O., Mahboub, B., Martinez‐Infante, E., Matricardi, P., Miculinic, N., Migueres, N., Mihaltan, F., Mohammad, Y., Moniuszko, M., Montefort, S., Neffen, H., Nekam, K., Nunes, E., Nyembue Tshipukane, D., O’Hehir, R., Ogulur, I., Ohta, K., Okubo, K., Ouedraogo, S., Olze, H., Pali‐Schöll, I., Palomares, O., Palosuo, K., Panaitescu, C., Panzner, P., Park, H. S., Pitsios, C., Plavec, D., Popov, T. A., Puggioni, F., Quirce, S., Recto, M., Repka‐Ramirez, M. S., Robalo Cordeiro, C., Roche, N., Rodriguez‐Gonzalez, M., Romantowski, J., Rosario Filho, N., Rottem, M., Sagara, H., Serpa, F. S., Sayah, Z., Scheire, S., Schmid‐Grendelmeier, P., Sisul, J. C., Sole, D., Soto‐Martinez, M., Sova, M., Sperl, A., Spranger, O., Stelmach, R., Suppli Ulrik, C., Thomas, M., To, T., Todo‐Bom, A., Tomazic, P. V., Urrutia‐Pereira, M., Valentin‐Rostan, M., Van Ganse, E., van Hage, M., Vasankari, T., Vichyanond, P., Viegi, G., Wallace, D., Wang, D. Y., Williams, S., Worm, M., Yiallouros, P., Yusuf, O., Zaitoun, F., Zernotti, M., Zidarn, M., Zuberbier, J., Fonseca, J. A., Zuberbier, T., Anto, J. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/57349
Resumo: © 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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spelling Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesisIL-33Toll-like receptorsAsthmaMultimorbidityRhinitis© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.WileyRepositório da Universidade de LisboaBousquet, J.Melén, E.Haahtela, T.Koppelman, G. H.Togias, A.Valenta, R.Akdis, C. A.Czarlewski, W.Rothenberg, M.Valiulis, A.Wickman, M.Akdis, M.Aguilar, D.Bedbrook, A.Bindslev‐Jensen, C.Bosnic‐Anticevich, S.Boulet, L. P.Brightling, C. E.Brussino, L.Burte, E.Bustamante, M.Canonica, G. W.Cecchi, L.Celedon, J. C.Chaves Loureiro, C.Costa, E.Cruz, A. A.Erhola, M.Gemicioglu, B.Fokkens, W. J.Garcia‐Aymerich, J.Guerra, S.Heinrich, J.Ivancevich, J. C.Keil, T.Klimek, L.Kuna, P.Kupczyk, M.Kvedariene, V.Larenas‐Linnemann, D. E.Lemonnier, N.Lodrup Carlsen, K. C.Louis, R.Makela, M.Makris, M.Maurer, M.Momas, I.Morais‐Almeida, M.Mullol, J.Naclerio, R. N.Nadeau, K.Nadif, R.Niedoszytko, M.Okamoto, Y.Ollert, M.Papadopoulos, N. G.Passalacqua, G.Patella, V.Pawankar, R.Pham‐Thi, N.Pfaar, O.Regateiro, F. S.Ring, J.Rouadi, P. W.Samolinski, B.Sastre, J.Savouré, M.Scichilone, N.Shamji, M. H.Sheikh, A.Siroux, V.Sousa‐Pinto, B.Standl, M.Sunyer, J.Taborda‐Barata, L.Toppila‐Salmi, S.Torres, M. J.Tsiligianni, I.Valovirta, E.Vandenplas, O.Ventura, M. T.Weiss, S.Yorgancioglu, A.Zhang, L.Abdul Latiff, A. H.Aberer, W.Agache, I.Al‐Ahmad, M.Alobid, I.Ansotegui, I. J.Arshad, S. H.Asayag, E.Bárbara, CristinaBaharudin, A.Battur, L.Bennoor, K. S.Berghea, E. C.Bergmann, K. C.Bernstein, D.Bewick, M.Blain, H.Bonini, M.Braido, F.Buhl, R.Bumbacea, R. S.Bush, A.Calderon, M.Calvo‐Gil, M.Camargos, P.Caraballo, L.Cardona, V.Carr, W.Carreiro‐Martins, P.Casale, T.Cepeda Sarabia, A. M.Chandrasekharan, R.Charpin, D.Chen, Y. Z.Cherrez‐Ojeda, I.Chivato, T.Chkhartishvili, E.Christoff, G.Chu, D. K.Cingi, C.Correia de Sousa, J.Corrigan, C.Custovic, A.D’Amato, G.Del Giacco, S.De Blay, F.Devillier, P.Didier, A.do Ceu Teixeira, M.Dokic, D.Douagui, H.Doulaptsi, M.Durham, S.Dykewicz, M.Eiwegger, T.El‐Sayed, Z. A.Emuzyte, R.Fiocchi, A.Fyhrquist, N.Gomez, R. M.Gotua, M.Guzman, M. A.Hagemann, J.Hamamah, S.Halken, S.Halpin, D. M. G.Hofmann, M.Hossny, E.Hrubiško, M.Irani, C.Ispayeva, Z.Jares, E.Jartti, T.Jassem, E.Julge, K.Just, J.Jutel, M.Kaidashev, I.Kalayci, O.Kalyoncu, A. F.Kardas, P.Kirenga, B.Kraxner, H.Kull, I.Kulus, M.La Grutta, S.Lau, S.Le Tuyet Thi, L.Levin, M.Lipworth, B.Lourenço, O.Mahboub, B.Martinez‐Infante, E.Matricardi, P.Miculinic, N.Migueres, N.Mihaltan, F.Mohammad, Y.Moniuszko, M.Montefort, S.Neffen, H.Nekam, K.Nunes, E.Nyembue Tshipukane, D.O’Hehir, R.Ogulur, I.Ohta, K.Okubo, K.Ouedraogo, S.Olze, H.Pali‐Schöll, I.Palomares, O.Palosuo, K.Panaitescu, C.Panzner, P.Park, H. S.Pitsios, C.Plavec, D.Popov, T. A.Puggioni, F.Quirce, S.Recto, M.Repka‐Ramirez, M. S.Robalo Cordeiro, C.Roche, N.Rodriguez‐Gonzalez, M.Romantowski, J.Rosario Filho, N.Rottem, M.Sagara, H.Serpa, F. S.Sayah, Z.Scheire, S.Schmid‐Grendelmeier, P.Sisul, J. C.Sole, D.Soto‐Martinez, M.Sova, M.Sperl, A.Spranger, O.Stelmach, R.Suppli Ulrik, C.Thomas, M.To, T.Todo‐Bom, A.Tomazic, P. V.Urrutia‐Pereira, M.Valentin‐Rostan, M.Van Ganse, E.van Hage, M.Vasankari, T.Vichyanond, P.Viegi, G.Wallace, D.Wang, D. Y.Williams, S.Worm, M.Yiallouros, P.Yusuf, O.Zaitoun, F.Zernotti, M.Zidarn, M.Zuberbier, J.Fonseca, J. A.Zuberbier, T.Anto, J. M.2023-05-04T13:37:46Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/57349engAllergy. 2023 May;78(5):1169-12030105-453810.1111/all.156791398-9995info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:05:31Zoai:repositorio.ul.pt:10451/57349Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:07:46.414290Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
title Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
spellingShingle Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
Bousquet, J.
IL-33
Toll-like receptors
Asthma
Multimorbidity
Rhinitis
title_short Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
title_full Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
title_fullStr Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
title_full_unstemmed Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
title_sort Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
author Bousquet, J.
author_facet Bousquet, J.
Melén, E.
Haahtela, T.
Koppelman, G. H.
Togias, A.
Valenta, R.
Akdis, C. A.
Czarlewski, W.
Rothenberg, M.
Valiulis, A.
Wickman, M.
Akdis, M.
Aguilar, D.
Bedbrook, A.
Bindslev‐Jensen, C.
Bosnic‐Anticevich, S.
Boulet, L. P.
Brightling, C. E.
Brussino, L.
Burte, E.
Bustamante, M.
Canonica, G. W.
Cecchi, L.
Celedon, J. C.
Chaves Loureiro, C.
Costa, E.
Cruz, A. A.
Erhola, M.
Gemicioglu, B.
Fokkens, W. J.
Garcia‐Aymerich, J.
Guerra, S.
Heinrich, J.
Ivancevich, J. C.
Keil, T.
Klimek, L.
Kuna, P.
Kupczyk, M.
Kvedariene, V.
Larenas‐Linnemann, D. E.
Lemonnier, N.
Lodrup Carlsen, K. C.
Louis, R.
Makela, M.
Makris, M.
Maurer, M.
Momas, I.
Morais‐Almeida, M.
Mullol, J.
Naclerio, R. N.
Nadeau, K.
Nadif, R.
Niedoszytko, M.
Okamoto, Y.
Ollert, M.
Papadopoulos, N. G.
Passalacqua, G.
Patella, V.
Pawankar, R.
Pham‐Thi, N.
Pfaar, O.
Regateiro, F. S.
Ring, J.
Rouadi, P. W.
Samolinski, B.
Sastre, J.
Savouré, M.
Scichilone, N.
Shamji, M. H.
Sheikh, A.
Siroux, V.
Sousa‐Pinto, B.
Standl, M.
Sunyer, J.
Taborda‐Barata, L.
Toppila‐Salmi, S.
Torres, M. J.
Tsiligianni, I.
Valovirta, E.
Vandenplas, O.
Ventura, M. T.
Weiss, S.
Yorgancioglu, A.
Zhang, L.
Abdul Latiff, A. H.
Aberer, W.
Agache, I.
Al‐Ahmad, M.
Alobid, I.
Ansotegui, I. J.
Arshad, S. H.
Asayag, E.
Bárbara, Cristina
Baharudin, A.
Battur, L.
Bennoor, K. S.
Berghea, E. C.
Bergmann, K. C.
Bernstein, D.
Bewick, M.
Blain, H.
Bonini, M.
Braido, F.
Buhl, R.
Bumbacea, R. S.
Bush, A.
Calderon, M.
Calvo‐Gil, M.
Camargos, P.
Caraballo, L.
Cardona, V.
Carr, W.
Carreiro‐Martins, P.
Casale, T.
Cepeda Sarabia, A. M.
Chandrasekharan, R.
Charpin, D.
Chen, Y. Z.
Cherrez‐Ojeda, I.
Chivato, T.
Chkhartishvili, E.
Christoff, G.
Chu, D. K.
Cingi, C.
Correia de Sousa, J.
Corrigan, C.
Custovic, A.
D’Amato, G.
Del Giacco, S.
De Blay, F.
Devillier, P.
Didier, A.
do Ceu Teixeira, M.
Dokic, D.
Douagui, H.
Doulaptsi, M.
Durham, S.
Dykewicz, M.
Eiwegger, T.
El‐Sayed, Z. A.
Emuzyte, R.
Fiocchi, A.
Fyhrquist, N.
Gomez, R. M.
Gotua, M.
Guzman, M. A.
Hagemann, J.
Hamamah, S.
Halken, S.
Halpin, D. M. G.
Hofmann, M.
Hossny, E.
Hrubiško, M.
Irani, C.
Ispayeva, Z.
Jares, E.
Jartti, T.
Jassem, E.
Julge, K.
Just, J.
Jutel, M.
Kaidashev, I.
Kalayci, O.
Kalyoncu, A. F.
Kardas, P.
Kirenga, B.
Kraxner, H.
Kull, I.
Kulus, M.
La Grutta, S.
Lau, S.
Le Tuyet Thi, L.
Levin, M.
Lipworth, B.
Lourenço, O.
Mahboub, B.
Martinez‐Infante, E.
Matricardi, P.
Miculinic, N.
Migueres, N.
Mihaltan, F.
Mohammad, Y.
Moniuszko, M.
Montefort, S.
Neffen, H.
Nekam, K.
Nunes, E.
Nyembue Tshipukane, D.
O’Hehir, R.
Ogulur, I.
Ohta, K.
Okubo, K.
Ouedraogo, S.
Olze, H.
Pali‐Schöll, I.
Palomares, O.
Palosuo, K.
Panaitescu, C.
Panzner, P.
Park, H. S.
Pitsios, C.
Plavec, D.
Popov, T. A.
Puggioni, F.
Quirce, S.
Recto, M.
Repka‐Ramirez, M. S.
Robalo Cordeiro, C.
Roche, N.
Rodriguez‐Gonzalez, M.
Romantowski, J.
Rosario Filho, N.
Rottem, M.
Sagara, H.
Serpa, F. S.
Sayah, Z.
Scheire, S.
Schmid‐Grendelmeier, P.
Sisul, J. C.
Sole, D.
Soto‐Martinez, M.
Sova, M.
Sperl, A.
Spranger, O.
Stelmach, R.
Suppli Ulrik, C.
Thomas, M.
To, T.
Todo‐Bom, A.
Tomazic, P. V.
Urrutia‐Pereira, M.
Valentin‐Rostan, M.
Van Ganse, E.
van Hage, M.
Vasankari, T.
Vichyanond, P.
Viegi, G.
Wallace, D.
Wang, D. Y.
Williams, S.
Worm, M.
Yiallouros, P.
Yusuf, O.
Zaitoun, F.
Zernotti, M.
Zidarn, M.
Zuberbier, J.
Fonseca, J. A.
Zuberbier, T.
Anto, J. M.
author_role author
author2 Melén, E.
Haahtela, T.
Koppelman, G. H.
Togias, A.
Valenta, R.
Akdis, C. A.
Czarlewski, W.
Rothenberg, M.
Valiulis, A.
Wickman, M.
Akdis, M.
Aguilar, D.
Bedbrook, A.
Bindslev‐Jensen, C.
Bosnic‐Anticevich, S.
Boulet, L. P.
Brightling, C. E.
Brussino, L.
Burte, E.
Bustamante, M.
Canonica, G. W.
Cecchi, L.
Celedon, J. C.
Chaves Loureiro, C.
Costa, E.
Cruz, A. A.
Erhola, M.
Gemicioglu, B.
Fokkens, W. J.
Garcia‐Aymerich, J.
Guerra, S.
Heinrich, J.
Ivancevich, J. C.
Keil, T.
Klimek, L.
Kuna, P.
Kupczyk, M.
Kvedariene, V.
Larenas‐Linnemann, D. E.
Lemonnier, N.
Lodrup Carlsen, K. C.
Louis, R.
Makela, M.
Makris, M.
Maurer, M.
Momas, I.
Morais‐Almeida, M.
Mullol, J.
Naclerio, R. N.
Nadeau, K.
Nadif, R.
Niedoszytko, M.
Okamoto, Y.
Ollert, M.
Papadopoulos, N. G.
Passalacqua, G.
Patella, V.
Pawankar, R.
Pham‐Thi, N.
Pfaar, O.
Regateiro, F. S.
Ring, J.
Rouadi, P. W.
Samolinski, B.
Sastre, J.
Savouré, M.
Scichilone, N.
Shamji, M. H.
Sheikh, A.
Siroux, V.
Sousa‐Pinto, B.
Standl, M.
Sunyer, J.
Taborda‐Barata, L.
Toppila‐Salmi, S.
Torres, M. J.
Tsiligianni, I.
Valovirta, E.
Vandenplas, O.
Ventura, M. T.
Weiss, S.
Yorgancioglu, A.
Zhang, L.
Abdul Latiff, A. H.
Aberer, W.
Agache, I.
Al‐Ahmad, M.
Alobid, I.
Ansotegui, I. J.
Arshad, S. H.
Asayag, E.
Bárbara, Cristina
Baharudin, A.
Battur, L.
Bennoor, K. S.
Berghea, E. C.
Bergmann, K. C.
Bernstein, D.
Bewick, M.
Blain, H.
Bonini, M.
Braido, F.
Buhl, R.
Bumbacea, R. S.
Bush, A.
Calderon, M.
Calvo‐Gil, M.
Camargos, P.
Caraballo, L.
Cardona, V.
Carr, W.
Carreiro‐Martins, P.
Casale, T.
Cepeda Sarabia, A. M.
Chandrasekharan, R.
Charpin, D.
Chen, Y. Z.
Cherrez‐Ojeda, I.
Chivato, T.
Chkhartishvili, E.
Christoff, G.
Chu, D. K.
Cingi, C.
Correia de Sousa, J.
Corrigan, C.
Custovic, A.
D’Amato, G.
Del Giacco, S.
De Blay, F.
Devillier, P.
Didier, A.
do Ceu Teixeira, M.
Dokic, D.
Douagui, H.
Doulaptsi, M.
Durham, S.
Dykewicz, M.
Eiwegger, T.
El‐Sayed, Z. A.
Emuzyte, R.
Fiocchi, A.
Fyhrquist, N.
Gomez, R. M.
Gotua, M.
Guzman, M. A.
Hagemann, J.
Hamamah, S.
Halken, S.
Halpin, D. M. G.
Hofmann, M.
Hossny, E.
Hrubiško, M.
Irani, C.
Ispayeva, Z.
Jares, E.
Jartti, T.
Jassem, E.
Julge, K.
Just, J.
Jutel, M.
Kaidashev, I.
Kalayci, O.
Kalyoncu, A. F.
Kardas, P.
Kirenga, B.
Kraxner, H.
Kull, I.
Kulus, M.
La Grutta, S.
Lau, S.
Le Tuyet Thi, L.
Levin, M.
Lipworth, B.
Lourenço, O.
Mahboub, B.
Martinez‐Infante, E.
Matricardi, P.
Miculinic, N.
Migueres, N.
Mihaltan, F.
Mohammad, Y.
Moniuszko, M.
Montefort, S.
Neffen, H.
Nekam, K.
Nunes, E.
Nyembue Tshipukane, D.
O’Hehir, R.
Ogulur, I.
Ohta, K.
Okubo, K.
Ouedraogo, S.
Olze, H.
Pali‐Schöll, I.
Palomares, O.
Palosuo, K.
Panaitescu, C.
Panzner, P.
Park, H. S.
Pitsios, C.
Plavec, D.
Popov, T. A.
Puggioni, F.
Quirce, S.
Recto, M.
Repka‐Ramirez, M. S.
Robalo Cordeiro, C.
Roche, N.
Rodriguez‐Gonzalez, M.
Romantowski, J.
Rosario Filho, N.
Rottem, M.
Sagara, H.
Serpa, F. S.
Sayah, Z.
Scheire, S.
Schmid‐Grendelmeier, P.
Sisul, J. C.
Sole, D.
Soto‐Martinez, M.
Sova, M.
Sperl, A.
Spranger, O.
Stelmach, R.
Suppli Ulrik, C.
Thomas, M.
To, T.
Todo‐Bom, A.
Tomazic, P. V.
Urrutia‐Pereira, M.
Valentin‐Rostan, M.
Van Ganse, E.
van Hage, M.
Vasankari, T.
Vichyanond, P.
Viegi, G.
Wallace, D.
Wang, D. Y.
Williams, S.
Worm, M.
Yiallouros, P.
Yusuf, O.
Zaitoun, F.
Zernotti, M.
Zidarn, M.
Zuberbier, J.
Fonseca, J. A.
Zuberbier, T.
Anto, J. M.
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Bousquet, J.
Melén, E.
Haahtela, T.
Koppelman, G. H.
Togias, A.
Valenta, R.
Akdis, C. A.
Czarlewski, W.
Rothenberg, M.
Valiulis, A.
Wickman, M.
Akdis, M.
Aguilar, D.
Bedbrook, A.
Bindslev‐Jensen, C.
Bosnic‐Anticevich, S.
Boulet, L. P.
Brightling, C. E.
Brussino, L.
Burte, E.
Bustamante, M.
Canonica, G. W.
Cecchi, L.
Celedon, J. C.
Chaves Loureiro, C.
Costa, E.
Cruz, A. A.
Erhola, M.
Gemicioglu, B.
Fokkens, W. J.
Garcia‐Aymerich, J.
Guerra, S.
Heinrich, J.
Ivancevich, J. C.
Keil, T.
Klimek, L.
Kuna, P.
Kupczyk, M.
Kvedariene, V.
Larenas‐Linnemann, D. E.
Lemonnier, N.
Lodrup Carlsen, K. C.
Louis, R.
Makela, M.
Makris, M.
Maurer, M.
Momas, I.
Morais‐Almeida, M.
Mullol, J.
Naclerio, R. N.
Nadeau, K.
Nadif, R.
Niedoszytko, M.
Okamoto, Y.
Ollert, M.
Papadopoulos, N. G.
Passalacqua, G.
Patella, V.
Pawankar, R.
Pham‐Thi, N.
Pfaar, O.
Regateiro, F. S.
Ring, J.
Rouadi, P. W.
Samolinski, B.
Sastre, J.
Savouré, M.
Scichilone, N.
Shamji, M. H.
Sheikh, A.
Siroux, V.
Sousa‐Pinto, B.
Standl, M.
Sunyer, J.
Taborda‐Barata, L.
Toppila‐Salmi, S.
Torres, M. J.
Tsiligianni, I.
Valovirta, E.
Vandenplas, O.
Ventura, M. T.
Weiss, S.
Yorgancioglu, A.
Zhang, L.
Abdul Latiff, A. H.
Aberer, W.
Agache, I.
Al‐Ahmad, M.
Alobid, I.
Ansotegui, I. J.
Arshad, S. H.
Asayag, E.
Bárbara, Cristina
Baharudin, A.
Battur, L.
Bennoor, K. S.
Berghea, E. C.
Bergmann, K. C.
Bernstein, D.
Bewick, M.
Blain, H.
Bonini, M.
Braido, F.
Buhl, R.
Bumbacea, R. S.
Bush, A.
Calderon, M.
Calvo‐Gil, M.
Camargos, P.
Caraballo, L.
Cardona, V.
Carr, W.
Carreiro‐Martins, P.
Casale, T.
Cepeda Sarabia, A. M.
Chandrasekharan, R.
Charpin, D.
Chen, Y. Z.
Cherrez‐Ojeda, I.
Chivato, T.
Chkhartishvili, E.
Christoff, G.
Chu, D. K.
Cingi, C.
Correia de Sousa, J.
Corrigan, C.
Custovic, A.
D’Amato, G.
Del Giacco, S.
De Blay, F.
Devillier, P.
Didier, A.
do Ceu Teixeira, M.
Dokic, D.
Douagui, H.
Doulaptsi, M.
Durham, S.
Dykewicz, M.
Eiwegger, T.
El‐Sayed, Z. A.
Emuzyte, R.
Fiocchi, A.
Fyhrquist, N.
Gomez, R. M.
Gotua, M.
Guzman, M. A.
Hagemann, J.
Hamamah, S.
Halken, S.
Halpin, D. M. G.
Hofmann, M.
Hossny, E.
Hrubiško, M.
Irani, C.
Ispayeva, Z.
Jares, E.
Jartti, T.
Jassem, E.
Julge, K.
Just, J.
Jutel, M.
Kaidashev, I.
Kalayci, O.
Kalyoncu, A. F.
Kardas, P.
Kirenga, B.
Kraxner, H.
Kull, I.
Kulus, M.
La Grutta, S.
Lau, S.
Le Tuyet Thi, L.
Levin, M.
Lipworth, B.
Lourenço, O.
Mahboub, B.
Martinez‐Infante, E.
Matricardi, P.
Miculinic, N.
Migueres, N.
Mihaltan, F.
Mohammad, Y.
Moniuszko, M.
Montefort, S.
Neffen, H.
Nekam, K.
Nunes, E.
Nyembue Tshipukane, D.
O’Hehir, R.
Ogulur, I.
Ohta, K.
Okubo, K.
Ouedraogo, S.
Olze, H.
Pali‐Schöll, I.
Palomares, O.
Palosuo, K.
Panaitescu, C.
Panzner, P.
Park, H. S.
Pitsios, C.
Plavec, D.
Popov, T. A.
Puggioni, F.
Quirce, S.
Recto, M.
Repka‐Ramirez, M. S.
Robalo Cordeiro, C.
Roche, N.
Rodriguez‐Gonzalez, M.
Romantowski, J.
Rosario Filho, N.
Rottem, M.
Sagara, H.
Serpa, F. S.
Sayah, Z.
Scheire, S.
Schmid‐Grendelmeier, P.
Sisul, J. C.
Sole, D.
Soto‐Martinez, M.
Sova, M.
Sperl, A.
Spranger, O.
Stelmach, R.
Suppli Ulrik, C.
Thomas, M.
To, T.
Todo‐Bom, A.
Tomazic, P. V.
Urrutia‐Pereira, M.
Valentin‐Rostan, M.
Van Ganse, E.
van Hage, M.
Vasankari, T.
Vichyanond, P.
Viegi, G.
Wallace, D.
Wang, D. Y.
Williams, S.
Worm, M.
Yiallouros, P.
Yusuf, O.
Zaitoun, F.
Zernotti, M.
Zidarn, M.
Zuberbier, J.
Fonseca, J. A.
Zuberbier, T.
Anto, J. M.
dc.subject.por.fl_str_mv IL-33
Toll-like receptors
Asthma
Multimorbidity
Rhinitis
topic IL-33
Toll-like receptors
Asthma
Multimorbidity
Rhinitis
description © 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
publishDate 2023
dc.date.none.fl_str_mv 2023-05-04T13:37:46Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/57349
url http://hdl.handle.net/10451/57349
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Allergy. 2023 May;78(5):1169-1203
0105-4538
10.1111/all.15679
1398-9995
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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