Miniaturized Membrane Sensors for the Determination of Orphenadrine Citrate
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042011000300003 |
Resumo: | Novel miniaturized polyvinyl chloride (PVC) membrane sensors in all-solid state graphite and platinum wire supports were developed, electrochemically evaluated and used for the assay of orphenadrine citrate (ORP). The ORP sensors were based on the formation of an ion-association complex between the drug cation and tetrakis(4- chlorophenyl)borate (TpClPB) anionic exchanger as electroactive material dispersed in a PVC matrix. Linear responses of 10-2 - 10-5 M and 10-2-10-4 M with cationic slopes of 56.4 mV and 53.6 mV over the pH range 4-7 were obtained by using the ORP-coated graphite (sensor 1) and platinum wire (sensor 2) membrane sensors, respectively. The proposed methods displayed useful analytical characteristics for the determination of ORP in Norflex® tablets with average recoveries of 100.01±0.83, 100.09±0.90, and in plasma with average recoveries of 99.4±0.97 and 98.55±0.82, for sensor 1 and 2, respectively. The methods were also used to determine the intact drug in the presence of its degradate and thus could be used as stability indicating methods. The results obtained by the proposed procedures were statistically analyzed and compared with those obtained by using an official method. No significant difference for both accuracy and precision was observed. |
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Miniaturized Membrane Sensors for the Determination of Orphenadrine Citrateorphenadrine citratepotentiometrystability indicating methodtetrakis(4- chlorophenyl) borateplasmaNovel miniaturized polyvinyl chloride (PVC) membrane sensors in all-solid state graphite and platinum wire supports were developed, electrochemically evaluated and used for the assay of orphenadrine citrate (ORP). The ORP sensors were based on the formation of an ion-association complex between the drug cation and tetrakis(4- chlorophenyl)borate (TpClPB) anionic exchanger as electroactive material dispersed in a PVC matrix. Linear responses of 10-2 - 10-5 M and 10-2-10-4 M with cationic slopes of 56.4 mV and 53.6 mV over the pH range 4-7 were obtained by using the ORP-coated graphite (sensor 1) and platinum wire (sensor 2) membrane sensors, respectively. The proposed methods displayed useful analytical characteristics for the determination of ORP in Norflex® tablets with average recoveries of 100.01±0.83, 100.09±0.90, and in plasma with average recoveries of 99.4±0.97 and 98.55±0.82, for sensor 1 and 2, respectively. The methods were also used to determine the intact drug in the presence of its degradate and thus could be used as stability indicating methods. The results obtained by the proposed procedures were statistically analyzed and compared with those obtained by using an official method. No significant difference for both accuracy and precision was observed.Sociedade Portuguesa de Electroquímica2011-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042011000300003Portugaliae Electrochimica Acta v.29 n.3 2011reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042011000300003Nebsen,MarianneEl-Rahman,Mohamed K. AbdEl-Kosasy,Amira M.Salem,Maissa Y.El-Bardicy,Mohamed G.info:eu-repo/semantics/openAccess2024-02-06T17:07:07Zoai:scielo:S0872-19042011000300003Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:10.663649Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Miniaturized Membrane Sensors for the Determination of Orphenadrine Citrate |
title |
Miniaturized Membrane Sensors for the Determination of Orphenadrine Citrate |
spellingShingle |
Miniaturized Membrane Sensors for the Determination of Orphenadrine Citrate Nebsen,Marianne orphenadrine citrate potentiometry stability indicating method tetrakis(4- chlorophenyl) borate plasma |
title_short |
Miniaturized Membrane Sensors for the Determination of Orphenadrine Citrate |
title_full |
Miniaturized Membrane Sensors for the Determination of Orphenadrine Citrate |
title_fullStr |
Miniaturized Membrane Sensors for the Determination of Orphenadrine Citrate |
title_full_unstemmed |
Miniaturized Membrane Sensors for the Determination of Orphenadrine Citrate |
title_sort |
Miniaturized Membrane Sensors for the Determination of Orphenadrine Citrate |
author |
Nebsen,Marianne |
author_facet |
Nebsen,Marianne El-Rahman,Mohamed K. Abd El-Kosasy,Amira M. Salem,Maissa Y. El-Bardicy,Mohamed G. |
author_role |
author |
author2 |
El-Rahman,Mohamed K. Abd El-Kosasy,Amira M. Salem,Maissa Y. El-Bardicy,Mohamed G. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Nebsen,Marianne El-Rahman,Mohamed K. Abd El-Kosasy,Amira M. Salem,Maissa Y. El-Bardicy,Mohamed G. |
dc.subject.por.fl_str_mv |
orphenadrine citrate potentiometry stability indicating method tetrakis(4- chlorophenyl) borate plasma |
topic |
orphenadrine citrate potentiometry stability indicating method tetrakis(4- chlorophenyl) borate plasma |
description |
Novel miniaturized polyvinyl chloride (PVC) membrane sensors in all-solid state graphite and platinum wire supports were developed, electrochemically evaluated and used for the assay of orphenadrine citrate (ORP). The ORP sensors were based on the formation of an ion-association complex between the drug cation and tetrakis(4- chlorophenyl)borate (TpClPB) anionic exchanger as electroactive material dispersed in a PVC matrix. Linear responses of 10-2 - 10-5 M and 10-2-10-4 M with cationic slopes of 56.4 mV and 53.6 mV over the pH range 4-7 were obtained by using the ORP-coated graphite (sensor 1) and platinum wire (sensor 2) membrane sensors, respectively. The proposed methods displayed useful analytical characteristics for the determination of ORP in Norflex® tablets with average recoveries of 100.01±0.83, 100.09±0.90, and in plasma with average recoveries of 99.4±0.97 and 98.55±0.82, for sensor 1 and 2, respectively. The methods were also used to determine the intact drug in the presence of its degradate and thus could be used as stability indicating methods. The results obtained by the proposed procedures were statistically analyzed and compared with those obtained by using an official method. No significant difference for both accuracy and precision was observed. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042011000300003 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042011000300003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042011000300003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Electroquímica |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Electroquímica |
dc.source.none.fl_str_mv |
Portugaliae Electrochimica Acta v.29 n.3 2011 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137290434379776 |