Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042009000400004 |
Resumo: | Three polyvinylchloride (PVC) membrane sensors for the determination of moexipril hydrochloride were prepared and characterized. The sensors are based on the use of the ion association complexes of moexipril cation with either ammonium reineckate (sensor 1) or tetraphenyl borate (sensor 2) or phosphotungistic acid (sensor 3) counter anions as ion exchange sites in the PVC matrix. The performance characteristics of these sensors were evaluated according to IUPAC recommendations, which reveal a fast, stable and linear response for moexipril over the concentration range of 10-6 to 10-2 M for the three sensors with cationic slopes of 29.1, 30.1 and 30.2 mV per concentration decade for the three sensors, respectively. The direct potentiometric determination of moexipril hydrochloride using the proposed sensors gave recoveries % of 99.64 ± 0.34, 99.34 ± 0.56 and 99.68 ± 0.42 for the three sensors, respectively. The sensors were used for determination of moexipril hydrochloride in pharmaceutical formulations and in plasma. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of moexipril hydrochloride. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method. |
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Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluidsmoexipril hydrochlorideion selective electrodesPVC membranesammonium reneickatetetraphenyl boratephosphotungistic acidThree polyvinylchloride (PVC) membrane sensors for the determination of moexipril hydrochloride were prepared and characterized. The sensors are based on the use of the ion association complexes of moexipril cation with either ammonium reineckate (sensor 1) or tetraphenyl borate (sensor 2) or phosphotungistic acid (sensor 3) counter anions as ion exchange sites in the PVC matrix. The performance characteristics of these sensors were evaluated according to IUPAC recommendations, which reveal a fast, stable and linear response for moexipril over the concentration range of 10-6 to 10-2 M for the three sensors with cationic slopes of 29.1, 30.1 and 30.2 mV per concentration decade for the three sensors, respectively. The direct potentiometric determination of moexipril hydrochloride using the proposed sensors gave recoveries % of 99.64 ± 0.34, 99.34 ± 0.56 and 99.68 ± 0.42 for the three sensors, respectively. The sensors were used for determination of moexipril hydrochloride in pharmaceutical formulations and in plasma. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of moexipril hydrochloride. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method.Sociedade Portuguesa de Electroquímica2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articletext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042009000400004Portugaliae Electrochimica Acta v.27 n.4 2009reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042009000400004Belal,F.Metwaly,F. H.Younes,K. M.Amer,S. M.info:eu-repo/semantics/openAccess2024-02-06T17:07:00Zoai:scielo:S0872-19042009000400004Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:20:07.114129Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids |
title |
Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids |
spellingShingle |
Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids Belal,F. moexipril hydrochloride ion selective electrodes PVC membranes ammonium reneickate tetraphenyl borate phosphotungistic acid |
title_short |
Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids |
title_full |
Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids |
title_fullStr |
Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids |
title_full_unstemmed |
Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids |
title_sort |
Development of Membrane Electrodes for the Specific Determination of Moexipril Hydrochloride in Dosage Forms and Biological Fluids |
author |
Belal,F. |
author_facet |
Belal,F. Metwaly,F. H. Younes,K. M. Amer,S. M. |
author_role |
author |
author2 |
Metwaly,F. H. Younes,K. M. Amer,S. M. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Belal,F. Metwaly,F. H. Younes,K. M. Amer,S. M. |
dc.subject.por.fl_str_mv |
moexipril hydrochloride ion selective electrodes PVC membranes ammonium reneickate tetraphenyl borate phosphotungistic acid |
topic |
moexipril hydrochloride ion selective electrodes PVC membranes ammonium reneickate tetraphenyl borate phosphotungistic acid |
description |
Three polyvinylchloride (PVC) membrane sensors for the determination of moexipril hydrochloride were prepared and characterized. The sensors are based on the use of the ion association complexes of moexipril cation with either ammonium reineckate (sensor 1) or tetraphenyl borate (sensor 2) or phosphotungistic acid (sensor 3) counter anions as ion exchange sites in the PVC matrix. The performance characteristics of these sensors were evaluated according to IUPAC recommendations, which reveal a fast, stable and linear response for moexipril over the concentration range of 10-6 to 10-2 M for the three sensors with cationic slopes of 29.1, 30.1 and 30.2 mV per concentration decade for the three sensors, respectively. The direct potentiometric determination of moexipril hydrochloride using the proposed sensors gave recoveries % of 99.64 ± 0.34, 99.34 ± 0.56 and 99.68 ± 0.42 for the three sensors, respectively. The sensors were used for determination of moexipril hydrochloride in pharmaceutical formulations and in plasma. Validation of the method shows suitability of the proposed sensors for use in quality control assessment of moexipril hydrochloride. The obtained results were in a good agreement with those obtained using the reported spectrophotometric method. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042009000400004 |
url |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042009000400004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-19042009000400004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Electroquímica |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Electroquímica |
dc.source.none.fl_str_mv |
Portugaliae Electrochimica Acta v.27 n.4 2009 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799137290325327872 |