Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin : a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responses

Detalhes bibliográficos
Autor(a) principal: Filipe, Paulo
Data de Publicação: 2013
Outros Autores: Morlière, Patrice, Silva, João N., Mazière, Jean-Claude, Patterson, Larry K., Freitas, João P., Santus, R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/45697
Resumo: Copyright © 2013 Paulo Filipe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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spelling Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin : a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responsesCopyright © 2013 Paulo Filipe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.There are numerous studies concerning the effect of UVB light on skin cells but fewer on other skin components such as the interstitial fluid. This review highlights high-density lipoprotein (HDL) and low-density lipoprotein (LDL) as important targets of UVB in interstitial fluid. Tryptophan residues are the sole apolipoprotein residues absorbing solar UVB. The UVB-induced one-electron oxidation of Trp produces (•)Trp and (•)O2 (-) radicals which trigger lipid peroxidation. Immunoblots from buffered solutions or suction blister fluid reveal that propagation of photooxidative damage to other residues such as Tyr or disulfide bonds produces intra- and intermolecular bonds in apolipoproteins A-I, A-II, and B100. Partial repair of phenoxyl tyrosyl radicals (TyrO(•)) by α -tocopherol is observed with LDL and HDL on millisecond or second time scales, whereas limited repair of α -tocopherol by carotenoids occurs in only HDL. More effective repair of Tyr and α -tocopherol is observed with the flavonoid, quercetin, bound to serum albumin, but quercetin is less potent than new synthetic polyphenols in inhibiting LDL lipid peroxidation or restoring α -tocopherol. The systemic consequences of HDL and LDL oxidation and the activation and/or inhibition of signalling pathways by oxidized LDL and their ability to enhance transcription factor DNA binding activity are also reviewed.HindawiRepositório da Universidade de LisboaFilipe, PauloMorlière, PatriceSilva, João N.Mazière, Jean-ClaudePatterson, Larry K.Freitas, João P.Santus, R.2021-01-07T17:51:38Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/45697engOxid Med Cell Longev. 2013; 2013: 2858251942-090010.1155/2013/2858251942-0994info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:47:40Zoai:repositorio.ul.pt:10451/45697Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:03.395978Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin : a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responses
title Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin : a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responses
spellingShingle Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin : a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responses
Filipe, Paulo
title_short Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin : a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responses
title_full Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin : a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responses
title_fullStr Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin : a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responses
title_full_unstemmed Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin : a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responses
title_sort Plasma lipoproteins as mediators of the oxidative stress induced by UV light in human skin : a review of biochemical and biophysical studies on mechanisms of apolipoprotein alteration, lipid peroxidation, and associated skin cell responses
author Filipe, Paulo
author_facet Filipe, Paulo
Morlière, Patrice
Silva, João N.
Mazière, Jean-Claude
Patterson, Larry K.
Freitas, João P.
Santus, R.
author_role author
author2 Morlière, Patrice
Silva, João N.
Mazière, Jean-Claude
Patterson, Larry K.
Freitas, João P.
Santus, R.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Filipe, Paulo
Morlière, Patrice
Silva, João N.
Mazière, Jean-Claude
Patterson, Larry K.
Freitas, João P.
Santus, R.
description Copyright © 2013 Paulo Filipe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
publishDate 2013
dc.date.none.fl_str_mv 2013
2013-01-01T00:00:00Z
2021-01-07T17:51:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/45697
url http://hdl.handle.net/10451/45697
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Oxid Med Cell Longev. 2013; 2013: 285825
1942-0900
10.1155/2013/285825
1942-0994
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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