Oral Contraceptives Interact with Adiposity-Associated Markers in Patients with Multiple Sclerosis

Detalhes bibliográficos
Autor(a) principal: Ferret-Sena, Véronique
Data de Publicação: 2024
Outros Autores: Ramos, Catarina, Cascais, Maria João, Capela, Carlos, Sena, Armando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/163791
Resumo: Funding Information: CiiEM has provided support through Project 10.54499/UIDB/04585/2020, funded by FCT. Publisher Copyright: © 2024 by the authors.
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spelling Oral Contraceptives Interact with Adiposity-Associated Markers in Patients with Multiple Sclerosisadiponectinadiposityageingmultiple sclerosisoral contraceptivesMedicine(all)Funding Information: CiiEM has provided support through Project 10.54499/UIDB/04585/2020, funded by FCT. Publisher Copyright: © 2024 by the authors.Growing evidence suggests the involvement of adipose tissue in modulating the clinical course of relapsing–remitting multiple sclerosis (RRMS). This study aimed to investigate whether the intake of combined oral contraceptives (COCs) affects body weight and leptin and adiponectin (APN) blood levels in these patients. Clinical data from 62 women (M = 33.23 year) were recorded prior to the initiation of disease-modifying therapy. Patients who were taking COCs at the time of experiencing the first symptoms of disease (COC user) were compared with those who never used these formulations or stopped taking them before disease onset (COC non-user). Bivariate Pearson’s correlations and hierarchical multiple linear regressions analysis were conducted. Normalized APN levels were lower in the COC-using patients (p = 0.013). Negative correlations between waist circumference and normalized APN (p = 0.001) were observed only in the COC non-user patients. A longer duration of COC intake was associated with increased body mass index and waist circumference (p = 0.003). Normalized APN predicted the MS Severity Score (MSSS) (p = 0.020), but this correlation was lost in the COC user patients. After adjusting for confounders, only age (p = 0.027) and, later, disease onset (p = 0.014) were correlated with the MSSS. Larger and prospective studies are needed to investigate the interactions of sex steroids with adipose metabolism in modulating disease progression.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFerret-Sena, VéroniqueRamos, CatarinaCascais, Maria JoãoCapela, CarlosSena, Armando2024-02-19T23:44:12Z2024-012024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/163791eng2077-0383PURE: 82798644https://doi.org/10.3390/jcm13020464info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:48:43Zoai:run.unl.pt:10362/163791Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:51.253774Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Oral Contraceptives Interact with Adiposity-Associated Markers in Patients with Multiple Sclerosis
title Oral Contraceptives Interact with Adiposity-Associated Markers in Patients with Multiple Sclerosis
spellingShingle Oral Contraceptives Interact with Adiposity-Associated Markers in Patients with Multiple Sclerosis
Ferret-Sena, Véronique
adiponectin
adiposity
ageing
multiple sclerosis
oral contraceptives
Medicine(all)
title_short Oral Contraceptives Interact with Adiposity-Associated Markers in Patients with Multiple Sclerosis
title_full Oral Contraceptives Interact with Adiposity-Associated Markers in Patients with Multiple Sclerosis
title_fullStr Oral Contraceptives Interact with Adiposity-Associated Markers in Patients with Multiple Sclerosis
title_full_unstemmed Oral Contraceptives Interact with Adiposity-Associated Markers in Patients with Multiple Sclerosis
title_sort Oral Contraceptives Interact with Adiposity-Associated Markers in Patients with Multiple Sclerosis
author Ferret-Sena, Véronique
author_facet Ferret-Sena, Véronique
Ramos, Catarina
Cascais, Maria João
Capela, Carlos
Sena, Armando
author_role author
author2 Ramos, Catarina
Cascais, Maria João
Capela, Carlos
Sena, Armando
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Ferret-Sena, Véronique
Ramos, Catarina
Cascais, Maria João
Capela, Carlos
Sena, Armando
dc.subject.por.fl_str_mv adiponectin
adiposity
ageing
multiple sclerosis
oral contraceptives
Medicine(all)
topic adiponectin
adiposity
ageing
multiple sclerosis
oral contraceptives
Medicine(all)
description Funding Information: CiiEM has provided support through Project 10.54499/UIDB/04585/2020, funded by FCT. Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-19T23:44:12Z
2024-01
2024-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/163791
url http://hdl.handle.net/10362/163791
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2077-0383
PURE: 82798644
https://doi.org/10.3390/jcm13020464
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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