Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries

Detalhes bibliográficos
Autor(a) principal: Perdigão, João
Data de Publicação: 2019
Outros Autores: Silva, Carla, Diniz, Jaciara, Pereira, Catarina, Machado, Diana, Ramos, Jorge, Silva, Hugo, Abilleira, Fernanda, Brum, Clarice, Reis, Ana J., Macedo, Maíra, Scaini, João L., Silva, Ana B., Esteves, Leonardo, Macedo, Rita, Maltez, Fernando, Clemente, Sofia, Coelho, Elizabeth, Portugal, Isabel Portugal
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/30477
Resumo: This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
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spelling Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countriesDrug resistanceLAMMIRU-VNTRMigrationMycobacteriaSpoligotypingTuberculosisThis is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).Tuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. To address this, we have assembled and analysed the largest CPLP M. tuberculosis molecular and drug susceptibility dataset, comprised by a total of 1447 clinical isolates, including 423 multidrug-resistant isolates, from five CPLP countries. The data herein presented reinforces Latin American and Mediterranean (LAM) strains as the hallmark of M. tuberculosis populational structure in the CPLP coupled with country-specific differential prevalence of minor clades. Moreover, using high-resolution typing by 24-loci MIRU-VNTR, six cross-border genetic clusters were detected, thus supporting recent clonal expansion across the Lusophone space. To make this data available to the scientific community and public health authorities we developed CPLP-TB (available at http://cplp-tb.ff.ulisboa.pt), an online database coupled with web-based tools for exploratory data analysis. As a public health tool, it is expected to contribute to improved knowledge on the M. tuberculosis population structure and strain circulation within the CPLP, thus supporting the risk assessment of strain-specific trends.ElsevierRepositório ComumPerdigão, JoãoSilva, CarlaDiniz, JaciaraPereira, CatarinaMachado, DianaRamos, JorgeSilva, HugoAbilleira, FernandaBrum, ClariceReis, Ana J.Macedo, MaíraScaini, João L.Silva, Ana B.Esteves, LeonardoMacedo, RitaMaltez, FernandoClemente, SofiaCoelho, ElizabethPortugal, Isabel Portugal2019-12-13T12:59:07Z2019-08-01T00:00:00Z2019-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/30477engInfect Genet Evol. 2019 Aug;72:44-58. doi: 10.1016/j.meegid.2018.03.0111567-134810.1016/j.meegid.2018.03.011info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:52Zoai:comum.rcaap.pt:10400.26/30477Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:38.347067Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries
title Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries
spellingShingle Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries
Perdigão, João
Drug resistance
LAM
MIRU-VNTR
Migration
Mycobacteria
Spoligotyping
Tuberculosis
title_short Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries
title_full Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries
title_fullStr Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries
title_full_unstemmed Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries
title_sort Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries
author Perdigão, João
author_facet Perdigão, João
Silva, Carla
Diniz, Jaciara
Pereira, Catarina
Machado, Diana
Ramos, Jorge
Silva, Hugo
Abilleira, Fernanda
Brum, Clarice
Reis, Ana J.
Macedo, Maíra
Scaini, João L.
Silva, Ana B.
Esteves, Leonardo
Macedo, Rita
Maltez, Fernando
Clemente, Sofia
Coelho, Elizabeth
Portugal, Isabel Portugal
author_role author
author2 Silva, Carla
Diniz, Jaciara
Pereira, Catarina
Machado, Diana
Ramos, Jorge
Silva, Hugo
Abilleira, Fernanda
Brum, Clarice
Reis, Ana J.
Macedo, Maíra
Scaini, João L.
Silva, Ana B.
Esteves, Leonardo
Macedo, Rita
Maltez, Fernando
Clemente, Sofia
Coelho, Elizabeth
Portugal, Isabel Portugal
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Perdigão, João
Silva, Carla
Diniz, Jaciara
Pereira, Catarina
Machado, Diana
Ramos, Jorge
Silva, Hugo
Abilleira, Fernanda
Brum, Clarice
Reis, Ana J.
Macedo, Maíra
Scaini, João L.
Silva, Ana B.
Esteves, Leonardo
Macedo, Rita
Maltez, Fernando
Clemente, Sofia
Coelho, Elizabeth
Portugal, Isabel Portugal
dc.subject.por.fl_str_mv Drug resistance
LAM
MIRU-VNTR
Migration
Mycobacteria
Spoligotyping
Tuberculosis
topic Drug resistance
LAM
MIRU-VNTR
Migration
Mycobacteria
Spoligotyping
Tuberculosis
description This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
publishDate 2019
dc.date.none.fl_str_mv 2019-12-13T12:59:07Z
2019-08-01T00:00:00Z
2019-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/30477
url http://hdl.handle.net/10400.26/30477
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Infect Genet Evol. 2019 Aug;72:44-58. doi: 10.1016/j.meegid.2018.03.011
1567-1348
10.1016/j.meegid.2018.03.011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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