European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/37962 |
Resumo: | Background: A previous European Headache Federation (EHF) guideline addressed the use of monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway to prevent migraine. Since then, randomized controlled trials (RCTs) and real-world evidence have expanded the evidence and knowledge for those treatments. Therefore, the EHF panel decided to provide an updated guideline on the use of those treatments. Methods: The guideline was developed following the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach. The working group identified relevant questions, performed a systematic review and an analysis of the literature, assessed the quality of the available evidence, and wrote recommendations. Where the GRADE approach was not applicable, expert opinion was provided. Results: We found moderate to high quality of evidence to recommend eptinezumab, erenumab, fremanezumab, and galcanezumab in individuals with episodic and chronic migraine. For several important clinical questions, we found not enough evidence to provide evidence-based recommendations and guidance relied on experts’ opinion. Nevertheless, we provided updated suggestions regarding the long-term management of those treatments and their place with respect to the other migraine preventatives. Conclusion: Monoclonal antibodies targeting the CGRP pathway are recommended for migraine prevention as they are effective and safe also in the long-term. |
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European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 updateCalcitonin gene-related pathwayGuidelineMigraineMonoclonal antibodiesPreventionBackground: A previous European Headache Federation (EHF) guideline addressed the use of monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway to prevent migraine. Since then, randomized controlled trials (RCTs) and real-world evidence have expanded the evidence and knowledge for those treatments. Therefore, the EHF panel decided to provide an updated guideline on the use of those treatments. Methods: The guideline was developed following the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach. The working group identified relevant questions, performed a systematic review and an analysis of the literature, assessed the quality of the available evidence, and wrote recommendations. Where the GRADE approach was not applicable, expert opinion was provided. Results: We found moderate to high quality of evidence to recommend eptinezumab, erenumab, fremanezumab, and galcanezumab in individuals with episodic and chronic migraine. For several important clinical questions, we found not enough evidence to provide evidence-based recommendations and guidance relied on experts’ opinion. Nevertheless, we provided updated suggestions regarding the long-term management of those treatments and their place with respect to the other migraine preventatives. Conclusion: Monoclonal antibodies targeting the CGRP pathway are recommended for migraine prevention as they are effective and safe also in the long-term.Veritati - Repositório Institucional da Universidade Católica PortuguesaSacco, SimonaAmin, Faisal MohammadAshina, MessoudBendtsen, LarsDeligianni, Christina I.Gil-Gouveia, RaquelKatsarava, ZazaMaassenVanDenBrink, AntoinetteMartelletti, PaoloMitsikostas, Dimos DimitriosOrnello, RaffaeleReuter, UweSanchez-del-Rio, MargaritaSinclair, Alexandra J.Terwindt, GiselaUluduz, DeryaVersijpt, JanLampl, Christian2022-06-24T08:23:35Z2022-06-112022-06-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/37962eng1129-236910.1186/s10194-022-01431-x85131902488PMC918816235690723000809558400001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-09T01:36:08Zoai:repositorio.ucp.pt:10400.14/37962Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:30:56.133582Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update |
title |
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update |
spellingShingle |
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update Sacco, Simona Calcitonin gene-related pathway Guideline Migraine Monoclonal antibodies Prevention |
title_short |
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update |
title_full |
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update |
title_fullStr |
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update |
title_full_unstemmed |
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update |
title_sort |
European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention – 2022 update |
author |
Sacco, Simona |
author_facet |
Sacco, Simona Amin, Faisal Mohammad Ashina, Messoud Bendtsen, Lars Deligianni, Christina I. Gil-Gouveia, Raquel Katsarava, Zaza MaassenVanDenBrink, Antoinette Martelletti, Paolo Mitsikostas, Dimos Dimitrios Ornello, Raffaele Reuter, Uwe Sanchez-del-Rio, Margarita Sinclair, Alexandra J. Terwindt, Gisela Uluduz, Derya Versijpt, Jan Lampl, Christian |
author_role |
author |
author2 |
Amin, Faisal Mohammad Ashina, Messoud Bendtsen, Lars Deligianni, Christina I. Gil-Gouveia, Raquel Katsarava, Zaza MaassenVanDenBrink, Antoinette Martelletti, Paolo Mitsikostas, Dimos Dimitrios Ornello, Raffaele Reuter, Uwe Sanchez-del-Rio, Margarita Sinclair, Alexandra J. Terwindt, Gisela Uluduz, Derya Versijpt, Jan Lampl, Christian |
author2_role |
author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Sacco, Simona Amin, Faisal Mohammad Ashina, Messoud Bendtsen, Lars Deligianni, Christina I. Gil-Gouveia, Raquel Katsarava, Zaza MaassenVanDenBrink, Antoinette Martelletti, Paolo Mitsikostas, Dimos Dimitrios Ornello, Raffaele Reuter, Uwe Sanchez-del-Rio, Margarita Sinclair, Alexandra J. Terwindt, Gisela Uluduz, Derya Versijpt, Jan Lampl, Christian |
dc.subject.por.fl_str_mv |
Calcitonin gene-related pathway Guideline Migraine Monoclonal antibodies Prevention |
topic |
Calcitonin gene-related pathway Guideline Migraine Monoclonal antibodies Prevention |
description |
Background: A previous European Headache Federation (EHF) guideline addressed the use of monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway to prevent migraine. Since then, randomized controlled trials (RCTs) and real-world evidence have expanded the evidence and knowledge for those treatments. Therefore, the EHF panel decided to provide an updated guideline on the use of those treatments. Methods: The guideline was developed following the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) approach. The working group identified relevant questions, performed a systematic review and an analysis of the literature, assessed the quality of the available evidence, and wrote recommendations. Where the GRADE approach was not applicable, expert opinion was provided. Results: We found moderate to high quality of evidence to recommend eptinezumab, erenumab, fremanezumab, and galcanezumab in individuals with episodic and chronic migraine. For several important clinical questions, we found not enough evidence to provide evidence-based recommendations and guidance relied on experts’ opinion. Nevertheless, we provided updated suggestions regarding the long-term management of those treatments and their place with respect to the other migraine preventatives. Conclusion: Monoclonal antibodies targeting the CGRP pathway are recommended for migraine prevention as they are effective and safe also in the long-term. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-24T08:23:35Z 2022-06-11 2022-06-11T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/37962 |
url |
http://hdl.handle.net/10400.14/37962 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1129-2369 10.1186/s10194-022-01431-x 85131902488 PMC9188162 35690723 000809558400001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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