Glioblastoma Multiforme Mimicking Limbic Encephalitis
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/268 |
Resumo: | Selective and bilateral involvement of the limbic system by gliomas is rarely reported. The authors report the case of a 58 years-male complaining of short-term memory loss in the preceding three weeks. The initial MRI revealed areas of hyperintensity on T2 and FLAIR sequences involving both hippocampus, amygdala, parahippocampus gyrus and the fornix, with contrast enhancement in the right mesial temporal region. Limbic encephalitis diagnosis was assumed and steroid therapy was applied. All other evaluation work-up was negative and follow-up imaging was compatible with tumor. The neuropathologic study of the right temporal lesion revealed glioblastoma multiforme. Glioblastoma can crossover through the commissural white matter to the opposite cerebral hemisphere, most often through the corpus callosum. However, selective and bilateral invasion of the limbic system is rare and when it occurs it may mimic limbic encephalitis. |
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Glioblastoma Multiforme Mimicking Limbic EncephalitisGlioblastoma Multiforme Mimetizando Encefalite LímbicaSelective and bilateral involvement of the limbic system by gliomas is rarely reported. The authors report the case of a 58 years-male complaining of short-term memory loss in the preceding three weeks. The initial MRI revealed areas of hyperintensity on T2 and FLAIR sequences involving both hippocampus, amygdala, parahippocampus gyrus and the fornix, with contrast enhancement in the right mesial temporal region. Limbic encephalitis diagnosis was assumed and steroid therapy was applied. All other evaluation work-up was negative and follow-up imaging was compatible with tumor. The neuropathologic study of the right temporal lesion revealed glioblastoma multiforme. Glioblastoma can crossover through the commissural white matter to the opposite cerebral hemisphere, most often through the corpus callosum. However, selective and bilateral invasion of the limbic system is rare and when it occurs it may mimic limbic encephalitis.Gliomas envolvendo o sistema límbico de forma selectiva e bilateral são raramente descritos. Os autores apresentam o caso clínico de um doente de 58 anos com queixas mnésicas com três semanas de evolução, cuja ressonância magnética (RM) inicial revelou áreas de hipersinal em T2 e FLAIR envolvendo ambos os hipocampos, as amígdalas, as circunvoluções parahipocâmpicas e o fórnix, com realce na região temporal mesial direita. Colocou-se a hipótese diagnóstica de encefalite límbica e instituiu-se corticoterapia. Todo o restante estudo complementar foi negativo e a evolução imagiológica foi compatível com lesão tumoral. O estudo anatomo-patológico da lesão temporal direita revelou glioblastoma multiforme. O glioblastoma pode difundir através das comissuras da substância branca para o hemisfério cerebral oposto, mais frequentemente através do corpo caloso. Contudo, é rara a invasão bilateral e selectiva do sistema límbico e quando ocorre pode mimetizar encefalite límbica.Ordem dos Médicos2012-11-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/x-pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/268oai:ojs.www.actamedicaportuguesa.com:article/268Acta Médica Portuguesa; Vol. 25 (2012): Supplement 1; 48-51Acta Médica Portuguesa; Vol. 25 (2012): Suplemento 1; 48-511646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/268https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/268/72Nunes, JoanaCarvalho, SílviaGouveia, PaulaShamasna, MotasemCosta, BrunoAlves, José LuisRocha, ArmandoPais, Rui Pedroinfo:eu-repo/semantics/openAccess2022-12-20T10:55:56Zoai:ojs.www.actamedicaportuguesa.com:article/268Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:16:24.603593Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Glioblastoma Multiforme Mimicking Limbic Encephalitis Glioblastoma Multiforme Mimetizando Encefalite Límbica |
title |
Glioblastoma Multiforme Mimicking Limbic Encephalitis |
spellingShingle |
Glioblastoma Multiforme Mimicking Limbic Encephalitis Nunes, Joana |
title_short |
Glioblastoma Multiforme Mimicking Limbic Encephalitis |
title_full |
Glioblastoma Multiforme Mimicking Limbic Encephalitis |
title_fullStr |
Glioblastoma Multiforme Mimicking Limbic Encephalitis |
title_full_unstemmed |
Glioblastoma Multiforme Mimicking Limbic Encephalitis |
title_sort |
Glioblastoma Multiforme Mimicking Limbic Encephalitis |
author |
Nunes, Joana |
author_facet |
Nunes, Joana Carvalho, Sílvia Gouveia, Paula Shamasna, Motasem Costa, Bruno Alves, José Luis Rocha, Armando Pais, Rui Pedro |
author_role |
author |
author2 |
Carvalho, Sílvia Gouveia, Paula Shamasna, Motasem Costa, Bruno Alves, José Luis Rocha, Armando Pais, Rui Pedro |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Nunes, Joana Carvalho, Sílvia Gouveia, Paula Shamasna, Motasem Costa, Bruno Alves, José Luis Rocha, Armando Pais, Rui Pedro |
description |
Selective and bilateral involvement of the limbic system by gliomas is rarely reported. The authors report the case of a 58 years-male complaining of short-term memory loss in the preceding three weeks. The initial MRI revealed areas of hyperintensity on T2 and FLAIR sequences involving both hippocampus, amygdala, parahippocampus gyrus and the fornix, with contrast enhancement in the right mesial temporal region. Limbic encephalitis diagnosis was assumed and steroid therapy was applied. All other evaluation work-up was negative and follow-up imaging was compatible with tumor. The neuropathologic study of the right temporal lesion revealed glioblastoma multiforme. Glioblastoma can crossover through the commissural white matter to the opposite cerebral hemisphere, most often through the corpus callosum. However, selective and bilateral invasion of the limbic system is rare and when it occurs it may mimic limbic encephalitis. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-11-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/268 oai:ojs.www.actamedicaportuguesa.com:article/268 |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/268 |
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oai:ojs.www.actamedicaportuguesa.com:article/268 |
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por |
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por |
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/268 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/268/72 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/x-pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 25 (2012): Supplement 1; 48-51 Acta Médica Portuguesa; Vol. 25 (2012): Suplemento 1; 48-51 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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