Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks

Detalhes bibliográficos
Autor(a) principal: Rodríguez Mallon, A.
Data de Publicação: 2023
Outros Autores: Encinosa Guzmán, P.E., Bello, Y., Domingos, A., Antunes, S., Kopacek, P., Santos, A.S., Velez, R., Perner, J., Ledesma Bravo, F.L., Frantova, H., Erhart, J., Rodríguez, R., Fuentes, A., Diago, D., Joglar, M., Méndez, L., Estrada, M.P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8986
Resumo: (This article belongs to the Collection Advances in Tick Research)
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spelling Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus TicksTicksP0 ProteinAnti-tick VaccineTick ControlVaccinationInfecções Sistémicas e Zoonoses(This article belongs to the Collection Advances in Tick Research)The control of ticks through vaccination offers a sustainable alternative to the use of chemicals that cause contamination and the selection of resistant tick strains. However, only a limited number of anti-tick vaccines have reached commercial realization. In this sense, an antigen effective against different tick species is a desirable target for developing such vaccines. A peptide derived from the tick P0 protein (pP0) conjugated to a carrier protein has been demonstrated to be effective against the Rhipicephalus microplus, Rhipicephalus sanguineus, and Amblyomma mixtum tick species. The aim of this work was to assess the efficacy of this peptide when conjugated to the Bm86 protein against Dermacentor nitens and Ixodes ricinus ticks. An RNAi experiment using P0 dsRNA from I. ricinus showed a dramatic reduction in the feeding of injected female ticks on guinea pigs. In the follow-up vaccination experiments, rabbits were immunized with the pP0-Bm86 conjugate and challenged simultaneously with larvae, nymphs, and the adults of I. ricinus ticks. In the same way, horses were immunized with the pP0-Bm86 conjugate and challenged with D. nitens larva. The pP0-Bm86 conjugate showed efficacies of 63% and 55% against I. ricinus and D. nitens ticks, respectively. These results, combined with previous reports of efficacy for this conjugate, show the promising potential for its development as a broad-spectrum anti-tick vaccine.This research was funded by the Center for Genetic Engineering and Biotechnology, Havana, Cuba, the Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Portugal, and the Czech Science Foundation grant no. 20-05736S. Mobility was supported by the CYTED Network INCOGARR 110RT0541.MDPIRepositório Científico do Instituto Nacional de SaúdeRodríguez Mallon, A.Encinosa Guzmán, P.E.Bello, Y.Domingos, A.Antunes, S.Kopacek, P.Santos, A.S.Velez, R.Perner, J.Ledesma Bravo, F.L.Frantova, H.Erhart, J.Rodríguez, R.Fuentes, A.Diago, D.Joglar, M.Méndez, L.Estrada, M.P.2024-01-29T14:06:42Z2023-11-172023-11-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8986engPathogens. 2023 Nov 17;12(11):1365. doi: 10.3390/pathogens12111365.2076-0817doi.org/ 10.3390/pathogens12111365info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-03T01:32:04Zoai:repositorio.insa.pt:10400.18/8986Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:07:37.133970Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks
title Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks
spellingShingle Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks
Rodríguez Mallon, A.
Ticks
P0 Protein
Anti-tick Vaccine
Tick Control
Vaccination
Infecções Sistémicas e Zoonoses
title_short Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks
title_full Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks
title_fullStr Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks
title_full_unstemmed Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks
title_sort Efficacy of the Vaccine Candidate Based on the P0 Peptide against Dermacentor nitens and Ixodes ricinus Ticks
author Rodríguez Mallon, A.
author_facet Rodríguez Mallon, A.
Encinosa Guzmán, P.E.
Bello, Y.
Domingos, A.
Antunes, S.
Kopacek, P.
Santos, A.S.
Velez, R.
Perner, J.
Ledesma Bravo, F.L.
Frantova, H.
Erhart, J.
Rodríguez, R.
Fuentes, A.
Diago, D.
Joglar, M.
Méndez, L.
Estrada, M.P.
author_role author
author2 Encinosa Guzmán, P.E.
Bello, Y.
Domingos, A.
Antunes, S.
Kopacek, P.
Santos, A.S.
Velez, R.
Perner, J.
Ledesma Bravo, F.L.
Frantova, H.
Erhart, J.
Rodríguez, R.
Fuentes, A.
Diago, D.
Joglar, M.
Méndez, L.
Estrada, M.P.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Rodríguez Mallon, A.
Encinosa Guzmán, P.E.
Bello, Y.
Domingos, A.
Antunes, S.
Kopacek, P.
Santos, A.S.
Velez, R.
Perner, J.
Ledesma Bravo, F.L.
Frantova, H.
Erhart, J.
Rodríguez, R.
Fuentes, A.
Diago, D.
Joglar, M.
Méndez, L.
Estrada, M.P.
dc.subject.por.fl_str_mv Ticks
P0 Protein
Anti-tick Vaccine
Tick Control
Vaccination
Infecções Sistémicas e Zoonoses
topic Ticks
P0 Protein
Anti-tick Vaccine
Tick Control
Vaccination
Infecções Sistémicas e Zoonoses
description (This article belongs to the Collection Advances in Tick Research)
publishDate 2023
dc.date.none.fl_str_mv 2023-11-17
2023-11-17T00:00:00Z
2024-01-29T14:06:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8986
url http://hdl.handle.net/10400.18/8986
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pathogens. 2023 Nov 17;12(11):1365. doi: 10.3390/pathogens12111365.
2076-0817
doi.org/ 10.3390/pathogens12111365
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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