Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography

Detalhes bibliográficos
Autor(a) principal: Soares, M
Data de Publicação: 2017
Outros Autores: Neves, C, Marques, I, Pires, I, Schwartz, C, Costa, MÂ, Santos, T, Durbin, M, Cunha-Vaz, J
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.4/2059
Resumo: PURPOSE: To analyse and compare the classification of eyes with diabetic retinopathy using fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) performed either with AngioPlex or AngioVue. METHODS: This was an observational cross-sectional study of 50 eyes from 26 diabetic subjects. Two independent graders classified the FA angiograms, to assess the presence and severity of several characteristics according to the ETDRS Report 11, and a similar evaluation was performed for each 3×3 mm OCTA image from the superficial retinal layer and for the full retina slab. RESULTS: Percentages of non-gradable images for the outline of foveal avascular zone (FAZ) in the central subfield (CSF) were 29.0% for FA, 12.0% for AngioVue and 3.0% for AngioPlex. For capillary loss, percentages of non-gradable images in the CSF were 25.0% for FA, 11% for AngioVue and 0.0% for AngioPlex. For the inner ring (IR), percentages of non-gradable images were 12.5% for FA, 11.5% for AngioVue and 0.5% for AngioPlex. Agreement between graders was substantial for outline of FAZ. For capillary loss, the agreement was fair for the CSF, and moderate for the IR. CONCLUSIONS: The OCTA allows better discrimination of the CSF and parafoveal macular microvasculature than FA, especially for FAZ disruption and capillary dropout, without the need of an intravenous injection of fluorescein. In addition, FA had also a higher number of non-gradable images. The OCTA can replace with advantage the FA, as a non-invasive and more sensitive procedure for detailed morphological evaluation of central macular vascular changes. TRIAL REGISTRATION NUMBER: NCT02391558, Pre-results.
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spelling Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiographyRetinopatia DiabéticaAngiofluoresceinografiaTomografia de Coerência ÓpticaVasos RetinianosPURPOSE: To analyse and compare the classification of eyes with diabetic retinopathy using fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) performed either with AngioPlex or AngioVue. METHODS: This was an observational cross-sectional study of 50 eyes from 26 diabetic subjects. Two independent graders classified the FA angiograms, to assess the presence and severity of several characteristics according to the ETDRS Report 11, and a similar evaluation was performed for each 3×3 mm OCTA image from the superficial retinal layer and for the full retina slab. RESULTS: Percentages of non-gradable images for the outline of foveal avascular zone (FAZ) in the central subfield (CSF) were 29.0% for FA, 12.0% for AngioVue and 3.0% for AngioPlex. For capillary loss, percentages of non-gradable images in the CSF were 25.0% for FA, 11% for AngioVue and 0.0% for AngioPlex. For the inner ring (IR), percentages of non-gradable images were 12.5% for FA, 11.5% for AngioVue and 0.5% for AngioPlex. Agreement between graders was substantial for outline of FAZ. For capillary loss, the agreement was fair for the CSF, and moderate for the IR. CONCLUSIONS: The OCTA allows better discrimination of the CSF and parafoveal macular microvasculature than FA, especially for FAZ disruption and capillary dropout, without the need of an intravenous injection of fluorescein. In addition, FA had also a higher number of non-gradable images. The OCTA can replace with advantage the FA, as a non-invasive and more sensitive procedure for detailed morphological evaluation of central macular vascular changes. TRIAL REGISTRATION NUMBER: NCT02391558, Pre-results.RIHUCSoares, MNeves, CMarques, IPires, ISchwartz, CCosta, MÂSantos, TDurbin, MCunha-Vaz, J2017-08-23T11:36:28Z2017-012017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/2059engBr J Ophthalmol. 2017 Jan;101(1):62-68.10.1136/bjophthalmol-2016-309424info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:23:22Zoai:rihuc.huc.min-saude.pt:10400.4/2059Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:04:31.883786Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography
title Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography
spellingShingle Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography
Soares, M
Retinopatia Diabética
Angiofluoresceinografia
Tomografia de Coerência Óptica
Vasos Retinianos
title_short Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography
title_full Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography
title_fullStr Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography
title_full_unstemmed Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography
title_sort Comparison of diabetic retinopathy classification using fluorescein angiography and optical coherence tomography angiography
author Soares, M
author_facet Soares, M
Neves, C
Marques, I
Pires, I
Schwartz, C
Costa, MÂ
Santos, T
Durbin, M
Cunha-Vaz, J
author_role author
author2 Neves, C
Marques, I
Pires, I
Schwartz, C
Costa, MÂ
Santos, T
Durbin, M
Cunha-Vaz, J
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv RIHUC
dc.contributor.author.fl_str_mv Soares, M
Neves, C
Marques, I
Pires, I
Schwartz, C
Costa, MÂ
Santos, T
Durbin, M
Cunha-Vaz, J
dc.subject.por.fl_str_mv Retinopatia Diabética
Angiofluoresceinografia
Tomografia de Coerência Óptica
Vasos Retinianos
topic Retinopatia Diabética
Angiofluoresceinografia
Tomografia de Coerência Óptica
Vasos Retinianos
description PURPOSE: To analyse and compare the classification of eyes with diabetic retinopathy using fluorescein angiography (FA) and optical coherence tomography angiography (OCTA) performed either with AngioPlex or AngioVue. METHODS: This was an observational cross-sectional study of 50 eyes from 26 diabetic subjects. Two independent graders classified the FA angiograms, to assess the presence and severity of several characteristics according to the ETDRS Report 11, and a similar evaluation was performed for each 3×3 mm OCTA image from the superficial retinal layer and for the full retina slab. RESULTS: Percentages of non-gradable images for the outline of foveal avascular zone (FAZ) in the central subfield (CSF) were 29.0% for FA, 12.0% for AngioVue and 3.0% for AngioPlex. For capillary loss, percentages of non-gradable images in the CSF were 25.0% for FA, 11% for AngioVue and 0.0% for AngioPlex. For the inner ring (IR), percentages of non-gradable images were 12.5% for FA, 11.5% for AngioVue and 0.5% for AngioPlex. Agreement between graders was substantial for outline of FAZ. For capillary loss, the agreement was fair for the CSF, and moderate for the IR. CONCLUSIONS: The OCTA allows better discrimination of the CSF and parafoveal macular microvasculature than FA, especially for FAZ disruption and capillary dropout, without the need of an intravenous injection of fluorescein. In addition, FA had also a higher number of non-gradable images. The OCTA can replace with advantage the FA, as a non-invasive and more sensitive procedure for detailed morphological evaluation of central macular vascular changes. TRIAL REGISTRATION NUMBER: NCT02391558, Pre-results.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-23T11:36:28Z
2017-01
2017-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Br J Ophthalmol. 2017 Jan;101(1):62-68.
10.1136/bjophthalmol-2016-309424
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