Immunogenicity of Reduced-Dose Monovalent Type 2 Oral Poliovirus Vaccine in Mocuba, Mozambique
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/147866 |
Resumo: | Funding Information: This work was supported by Rotary International, through a grant from the World Health Organization (grant 2019/889177-2). Publisher Copyright: © The Author(s) 2020. |
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Immunogenicity of Reduced-Dose Monovalent Type 2 Oral Poliovirus Vaccine in Mocuba, Mozambique1-dropimmunogenicitymonovalent type 2 oral poliovirus vaccine (mOPV2)MozambiqueRZ Other systems of medicineQR355 VirologyImmunology and AllergyInfectious DiseasesVirologySDG 3 - Good Health and Well-beingSDG 9 - Industry, Innovation, and InfrastructureSDG 10 - Reduced InequalitiesFunding Information: This work was supported by Rotary International, through a grant from the World Health Organization (grant 2019/889177-2). Publisher Copyright: © The Author(s) 2020.Background. The monovalent type 2 oral poliovirus vaccine (mOPV2) stockpile is low. One potential strategy to stretch the existing mOPV2 supply is to administer a reduced dose: 1 drop instead of 2. Methods. We conducted a randomized, controlled, open-label, noninferiority trial (10% margin) to compared immunogenicity after administration of 1 versus 2 drops of mOPV2. We enrolled 9–22-month-old infants from Mocuba district of Mozambique. Poliovirus neutralizing antibodies were measured in serum samples collected before and 1 month after mOPV2 administration. Immune response was defined as seroconversion from seronegative (<1:8) at baseline to seropositive (≥1:8) after vaccination or boosting titers by ≥4-fold for those with titers between 1:8 and 1:362 at baseline. The trial was registered at anzctr.org.au (no. ACTRN12619000184178p). Results. We enrolled 378 children, and 262 (69%) completed per-protocol requirements. The immune response of mOPV2 was 53.6% (95% confidence interval, 44.9%–62.1%) and 60.6% (52.2%–68.4%) in 1-drop and 2-drop recipients, respectively. The noninferiority margin of the 10% was not reached (difference, 7.0%; 95% confidence interval, −5.0% to 19.0%). Conclusion. A small loss of immunogenicity of reduced mOPV2 was observed. Although the noninferiority target was not achieved, the Strategic Advisory Group of Experts on Immunization recommended the 1-drop strategy as a dose-sparing measure if mOPV2 supplies deteriorate further.Instituto de Higiene e Medicina Tropical (IHMT)RUNde Deus, NilsaUbisse Capitine, Igor PauloLoforte Bauhofer, Adilson FernandoMarques, SelmaCassocera, MartaChissaque, AssucênioBero, Diocreciano MatiasLanga, José PauloPadama, Fernando ManuelJeyaseelan, VisalakshiSteven Oberste, M.Estivariz, Concepcion F.Verma, HarishJani, IleshMach, OndrejSutter, Roland W.2023-01-19T22:19:26Z2022-07-152022-07-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://hdl.handle.net/10362/147866eng0022-1899PURE: 50816858https://doi.org/10.1093/infdis/jiaa704info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:29:07Zoai:run.unl.pt:10362/147866Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:06.921466Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Immunogenicity of Reduced-Dose Monovalent Type 2 Oral Poliovirus Vaccine in Mocuba, Mozambique |
| title |
Immunogenicity of Reduced-Dose Monovalent Type 2 Oral Poliovirus Vaccine in Mocuba, Mozambique |
| spellingShingle |
Immunogenicity of Reduced-Dose Monovalent Type 2 Oral Poliovirus Vaccine in Mocuba, Mozambique de Deus, Nilsa 1-drop immunogenicity monovalent type 2 oral poliovirus vaccine (mOPV2) Mozambique RZ Other systems of medicine QR355 Virology Immunology and Allergy Infectious Diseases Virology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure SDG 10 - Reduced Inequalities |
| title_short |
Immunogenicity of Reduced-Dose Monovalent Type 2 Oral Poliovirus Vaccine in Mocuba, Mozambique |
| title_full |
Immunogenicity of Reduced-Dose Monovalent Type 2 Oral Poliovirus Vaccine in Mocuba, Mozambique |
| title_fullStr |
Immunogenicity of Reduced-Dose Monovalent Type 2 Oral Poliovirus Vaccine in Mocuba, Mozambique |
| title_full_unstemmed |
Immunogenicity of Reduced-Dose Monovalent Type 2 Oral Poliovirus Vaccine in Mocuba, Mozambique |
| title_sort |
Immunogenicity of Reduced-Dose Monovalent Type 2 Oral Poliovirus Vaccine in Mocuba, Mozambique |
| author |
de Deus, Nilsa |
| author_facet |
de Deus, Nilsa Ubisse Capitine, Igor Paulo Loforte Bauhofer, Adilson Fernando Marques, Selma Cassocera, Marta Chissaque, Assucênio Bero, Diocreciano Matias Langa, José Paulo Padama, Fernando Manuel Jeyaseelan, Visalakshi Steven Oberste, M. Estivariz, Concepcion F. Verma, Harish Jani, Ilesh Mach, Ondrej Sutter, Roland W. |
| author_role |
author |
| author2 |
Ubisse Capitine, Igor Paulo Loforte Bauhofer, Adilson Fernando Marques, Selma Cassocera, Marta Chissaque, Assucênio Bero, Diocreciano Matias Langa, José Paulo Padama, Fernando Manuel Jeyaseelan, Visalakshi Steven Oberste, M. Estivariz, Concepcion F. Verma, Harish Jani, Ilesh Mach, Ondrej Sutter, Roland W. |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) RUN |
| dc.contributor.author.fl_str_mv |
de Deus, Nilsa Ubisse Capitine, Igor Paulo Loforte Bauhofer, Adilson Fernando Marques, Selma Cassocera, Marta Chissaque, Assucênio Bero, Diocreciano Matias Langa, José Paulo Padama, Fernando Manuel Jeyaseelan, Visalakshi Steven Oberste, M. Estivariz, Concepcion F. Verma, Harish Jani, Ilesh Mach, Ondrej Sutter, Roland W. |
| dc.subject.por.fl_str_mv |
1-drop immunogenicity monovalent type 2 oral poliovirus vaccine (mOPV2) Mozambique RZ Other systems of medicine QR355 Virology Immunology and Allergy Infectious Diseases Virology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure SDG 10 - Reduced Inequalities |
| topic |
1-drop immunogenicity monovalent type 2 oral poliovirus vaccine (mOPV2) Mozambique RZ Other systems of medicine QR355 Virology Immunology and Allergy Infectious Diseases Virology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure SDG 10 - Reduced Inequalities |
| description |
Funding Information: This work was supported by Rotary International, through a grant from the World Health Organization (grant 2019/889177-2). Publisher Copyright: © The Author(s) 2020. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-07-15 2022-07-15T00:00:00Z 2023-01-19T22:19:26Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/147866 |
| url |
http://hdl.handle.net/10362/147866 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0022-1899 PURE: 50816858 https://doi.org/10.1093/infdis/jiaa704 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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7 application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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