Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis

Detalhes bibliográficos
Autor(a) principal: Duarte, T.
Data de Publicação: 2017
Outros Autores: Caldas, C., Santos, A., Silva-Gomes, S., Santos-Gonçalves, A., Martins, M., Porto, G., Lopes, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.16/2180
Resumo: In hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma. Most cases are ascribed to a common mutation in the HFE gene, but the extent of clinical expression is greatly influenced by the combined action of yet unidentified genetic and/or environmental modifying factors. In mice, transcription factor NRF2 is a critical determinant of hepatocyte viability during exposure to acute dietary iron overload. We evaluated if the genetic disruption of Nrf2 would prompt the development of liver damage in Hfe(-/-) mice (an established model of human HFE-hemochromatosis).
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spelling Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosisHepatocyteIronMacrophageOxidative stressSideronecrosisIn hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma. Most cases are ascribed to a common mutation in the HFE gene, but the extent of clinical expression is greatly influenced by the combined action of yet unidentified genetic and/or environmental modifying factors. In mice, transcription factor NRF2 is a critical determinant of hepatocyte viability during exposure to acute dietary iron overload. We evaluated if the genetic disruption of Nrf2 would prompt the development of liver damage in Hfe(-/-) mice (an established model of human HFE-hemochromatosis).This work was supported by National funds through Fundação para a Ciência e a Tecnologia/Ministério da Educação e Ciência (PTDC/SAU-FCF/101177/2008, PTDC/BIM-MET/0739/2012 and SFRH/BPD/108207/2015), by FEDER funds through the COMPETE – Operational Competitiveness Programme (FCOMP-01-0124-FEDER-011062 and FCOMP-01-0124-FEDER-028447) and Project Norte-01-0145-FEDER-000012, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (FEDER), and by Reitoria da Universidade do Porto/Santander through PP-IJUP2011-122.ElsevierRepositório Científico do Centro Hospitalar Universitário de Santo AntónioDuarte, T.Caldas, C.Santos, A.Silva-Gomes, S.Santos-Gonçalves, A.Martins, M.Porto, G.Lopes, J.2017-09-04T17:21:55Z2017-042017-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2180engRedox Biol. 2017 Apr;11:157-1692213-231710.1016/j.redox.2016.11.013info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-20T10:59:27Zoai:repositorio.chporto.pt:10400.16/2180Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:38:25.177292Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis
title Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis
spellingShingle Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis
Duarte, T.
Hepatocyte
Iron
Macrophage
Oxidative stress
Sideronecrosis
title_short Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis
title_full Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis
title_fullStr Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis
title_full_unstemmed Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis
title_sort Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis
author Duarte, T.
author_facet Duarte, T.
Caldas, C.
Santos, A.
Silva-Gomes, S.
Santos-Gonçalves, A.
Martins, M.
Porto, G.
Lopes, J.
author_role author
author2 Caldas, C.
Santos, A.
Silva-Gomes, S.
Santos-Gonçalves, A.
Martins, M.
Porto, G.
Lopes, J.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Centro Hospitalar Universitário de Santo António
dc.contributor.author.fl_str_mv Duarte, T.
Caldas, C.
Santos, A.
Silva-Gomes, S.
Santos-Gonçalves, A.
Martins, M.
Porto, G.
Lopes, J.
dc.subject.por.fl_str_mv Hepatocyte
Iron
Macrophage
Oxidative stress
Sideronecrosis
topic Hepatocyte
Iron
Macrophage
Oxidative stress
Sideronecrosis
description In hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma. Most cases are ascribed to a common mutation in the HFE gene, but the extent of clinical expression is greatly influenced by the combined action of yet unidentified genetic and/or environmental modifying factors. In mice, transcription factor NRF2 is a critical determinant of hepatocyte viability during exposure to acute dietary iron overload. We evaluated if the genetic disruption of Nrf2 would prompt the development of liver damage in Hfe(-/-) mice (an established model of human HFE-hemochromatosis).
publishDate 2017
dc.date.none.fl_str_mv 2017-09-04T17:21:55Z
2017-04
2017-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.16/2180
url http://hdl.handle.net/10400.16/2180
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Redox Biol. 2017 Apr;11:157-169
2213-2317
10.1016/j.redox.2016.11.013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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