Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response

Detalhes bibliográficos
Autor(a) principal: Mendes, B. B.
Data de Publicação: 2020
Outros Autores: Gomez-Florit, Manuel, Osório, H., Vilaça, A., Domingues, Rui Miguel Andrade, Reis, R. L., Gomes, Manuela E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/65446
Resumo: The surface chemistry of cellulose nanocrystals was engineered to show variable sulfation degrees, which was exploited to modulate platelet lysate-derived biomolecule sequestration and presentation. The protein coronas developed on CNC surfaces were characterized and it was demonstrated how they promote different signaling effects on human adipose-derived stem cell behavior.
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spelling Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell responseCellulose nanocrystalsPlatelet lysateprotein coronaThe surface chemistry of cellulose nanocrystals was engineered to show variable sulfation degrees, which was exploited to modulate platelet lysate-derived biomolecule sequestration and presentation. The protein coronas developed on CNC surfaces were characterized and it was demonstrated how they promote different signaling effects on human adipose-derived stem cell behavior.The research has received funding from PTDC/NAN-MAT/30595/2017, ERC Grant No. 772817; FCT/MCTES for PD/59/2013 - PD/BD/113807/2015, for ITI Research grant 1306_2018,ROTEIRO/0028/2013, and LISBOA-01-0145-FEDER-022125.Royal Society of ChemistryUniversidade do MinhoMendes, B. B.Gomez-Florit, ManuelOsório, H.Vilaça, A.Domingues, Rui Miguel AndradeReis, R. L.Gomes, Manuela E.2020-052020-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/65446engMendes B. B., Gómez-Florit M., Osório H., Vilaça A., Domingues R. M. A., Reis R. L., Gomes M. E. Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response, Chemical Communications, doi:10.1039/D0CC01850C, 20201473-760410.1039/D0CC01850C32435790https://pubs.rsc.org/en/content/articlelanding/2020/cc/d0cc01850c/unauth#!divAbstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:42:32Zoai:repositorium.sdum.uminho.pt:1822/65446Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:39:48.395790Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response
title Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response
spellingShingle Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response
Mendes, B. B.
Cellulose nanocrystals
Platelet lysate
protein corona
title_short Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response
title_full Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response
title_fullStr Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response
title_full_unstemmed Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response
title_sort Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response
author Mendes, B. B.
author_facet Mendes, B. B.
Gomez-Florit, Manuel
Osório, H.
Vilaça, A.
Domingues, Rui Miguel Andrade
Reis, R. L.
Gomes, Manuela E.
author_role author
author2 Gomez-Florit, Manuel
Osório, H.
Vilaça, A.
Domingues, Rui Miguel Andrade
Reis, R. L.
Gomes, Manuela E.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Mendes, B. B.
Gomez-Florit, Manuel
Osório, H.
Vilaça, A.
Domingues, Rui Miguel Andrade
Reis, R. L.
Gomes, Manuela E.
dc.subject.por.fl_str_mv Cellulose nanocrystals
Platelet lysate
protein corona
topic Cellulose nanocrystals
Platelet lysate
protein corona
description The surface chemistry of cellulose nanocrystals was engineered to show variable sulfation degrees, which was exploited to modulate platelet lysate-derived biomolecule sequestration and presentation. The protein coronas developed on CNC surfaces were characterized and it was demonstrated how they promote different signaling effects on human adipose-derived stem cell behavior.
publishDate 2020
dc.date.none.fl_str_mv 2020-05
2020-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/65446
url https://hdl.handle.net/1822/65446
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mendes B. B., Gómez-Florit M., Osório H., Vilaça A., Domingues R. M. A., Reis R. L., Gomes M. E. Cellulose nanocrystals of variable sulfation degrees can sequester specific platelet lysate-derived biomolecules to modulate stem cell response, Chemical Communications, doi:10.1039/D0CC01850C, 2020
1473-7604
10.1039/D0CC01850C
32435790
https://pubs.rsc.org/en/content/articlelanding/2020/cc/d0cc01850c/unauth#!divAbstract
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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