Profiling Persistent Asthma Phenotypes in Adolescents

Amaral, Rita; Jácome, Cristina; Almeida, Rute; Pereira, Ana Margarida; Alves-Correia, Magna; Mendes, Sandra; Rodrigues, José Carlos Cidrais; Carvalho, Joana; Araújo, Luís; Costa, Alberto; Silva, Armandina; Teixeira, Maria Fernanda; Ferreira-Magalhães, Manuel; Alves, Rodrigo Rodrigues; Moreira, Ana Sofia; Fernandes, Ricardo M; Ferreira, Rosário; Pinto, Paula Leiria; Neuparth, N; Bordalo, Diana; Bom, Ana Todo; Cálix, Maria José; Ferreira, Tânia; Gomes, Joana; Vidal, Carmen; Mendes, Ana; Vasconcelos, Maria João; Silva, Pedro Morais; Ferraz, José; Morête, Ana; Pinto, Claúdia Sofia; Santos, Natacha; Loureiro, Claúdia Chaves; Arrobas, Ana; Marques, Maria Luís; Lozoya, Carlos; Lopes, Cristina; Cardia, Francisca; Loureiro, Carla Chaves; Câmara, Raquel; Vieira, Inês; Silva, Sofia da; Silva, Eurico; Rodrigues, Natalina; Fonseca, João A

Profiling Persistent Asthma Phenotypes in Adolescents

Detalhes bibliográficos
Autor(a) principal:	Amaral, Rita
Data de Publicação:	2021
Outros Autores:	Jácome, Cristina, Almeida, Rute, Pereira, Ana Margarida, Alves-Correia, Magna, Mendes, Sandra, Rodrigues, José Carlos Cidrais, Carvalho, Joana, Araújo, Luís, Costa, Alberto, Silva, Armandina, Teixeira, Maria Fernanda, Ferreira-Magalhães, Manuel, Alves, Rodrigo Rodrigues, Moreira, Ana Sofia, Fernandes, Ricardo M, Ferreira, Rosário, Pinto, Paula Leiria, Neuparth, N, Bordalo, Diana, Bom, Ana Todo, Cálix, Maria José, Ferreira, Tânia, Gomes, Joana, Vidal, Carmen, Mendes, Ana, Vasconcelos, Maria João, Silva, Pedro Morais, Ferraz, José, Morête, Ana, Pinto, Claúdia Sofia, Santos, Natacha, Loureiro, Claúdia Chaves, Arrobas, Ana, Marques, Maria Luís, Lozoya, Carlos, Lopes, Cristina, Cardia, Francisca, Loureiro, Carla Chaves, Câmara, Raquel, Vieira, Inês, Silva, Sofia da, Silva, Eurico, Rodrigues, Natalina, Fonseca, João A
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo:	http://hdl.handle.net/10362/111251
Resumo:	Funding: This research was funded by ERDF (European Regional Development Fund) through the operations: POCI-01-0145-36 FEDER-029130 (“mINSPIRE—mHealth to measure and improve adherence to medication in chronic respiratory diseases—generalisation and evaluation of gamification, peer support and advanced image processing technologies”) cofunded by the COMPETE2020 (Programa Operacional Competitividade e Internacionalização), Portugal 2020 and by Portuguese Funds through FCT (Fundação para a Ciência e a Tecnologia).

Metadados do item

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oai_identifier_str	oai:run.unl.pt:10362/111251
network_acronym_str	RCAP
network_name_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str	7160
spelling	Profiling Persistent Asthma Phenotypes in AdolescentsA Longitudinal Diagnostic Evaluation from the INSPIRERS Studiesasthmaadolescentsphenotypesclusteringlongitudinal studieslatent class analysisSDG 3 - Good Health and Well-beingFunding: This research was funded by ERDF (European Regional Development Fund) through the operations: POCI-01-0145-36 FEDER-029130 (“mINSPIRE—mHealth to measure and improve adherence to medication in chronic respiratory diseases—generalisation and evaluation of gamification, peer support and advanced image processing technologies”) cofunded by the COMPETE2020 (Programa Operacional Competitividade e Internacionalização), Portugal 2020 and by Portuguese Funds through FCT (Fundação para a Ciência e a Tecnologia).We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.NOVA Medical School\|Faculdade de Ciências Médicas (NMS\|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNAmaral, RitaJácome, CristinaAlmeida, RutePereira, Ana MargaridaAlves-Correia, MagnaMendes, SandraRodrigues, José Carlos CidraisCarvalho, JoanaAraújo, LuísCosta, AlbertoSilva, ArmandinaTeixeira, Maria FernandaFerreira-Magalhães, ManuelAlves, Rodrigo RodriguesMoreira, Ana SofiaFernandes, Ricardo MFerreira, RosárioPinto, Paula LeiriaNeuparth, NBordalo, DianaBom, Ana TodoCálix, Maria JoséFerreira, TâniaGomes, JoanaVidal, CarmenMendes, AnaVasconcelos, Maria JoãoSilva, Pedro MoraisFerraz, JoséMorête, AnaPinto, Claúdia SofiaSantos, NatachaLoureiro, Claúdia ChavesArrobas, AnaMarques, Maria LuísLozoya, CarlosLopes, CristinaCardia, FranciscaLoureiro, Carla ChavesCâmara, RaquelVieira, InêsSilva, Sofia daSilva, EuricoRodrigues, NatalinaFonseca, João A2021-02-03T23:21:12Z2021-01-242021-01-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/111251eng1660-4601PURE: 27855565https://doi.org/10.3390/ijerph18031015info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:55:04Zoai:run.unl.pt:10362/111251Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:41:51.024702Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv	Profiling Persistent Asthma Phenotypes in Adolescents A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies
title	Profiling Persistent Asthma Phenotypes in Adolescents
spellingShingle	Profiling Persistent Asthma Phenotypes in Adolescents Amaral, Rita asthma adolescents phenotypes clustering longitudinal studies latent class analysis SDG 3 - Good Health and Well-being
title_short	Profiling Persistent Asthma Phenotypes in Adolescents
title_full	Profiling Persistent Asthma Phenotypes in Adolescents
title_fullStr	Profiling Persistent Asthma Phenotypes in Adolescents
title_full_unstemmed	Profiling Persistent Asthma Phenotypes in Adolescents
title_sort	Profiling Persistent Asthma Phenotypes in Adolescents
author	Amaral, Rita
author_facet	Amaral, Rita Jácome, Cristina Almeida, Rute Pereira, Ana Margarida Alves-Correia, Magna Mendes, Sandra Rodrigues, José Carlos Cidrais Carvalho, Joana Araújo, Luís Costa, Alberto Silva, Armandina Teixeira, Maria Fernanda Ferreira-Magalhães, Manuel Alves, Rodrigo Rodrigues Moreira, Ana Sofia Fernandes, Ricardo M Ferreira, Rosário Pinto, Paula Leiria Neuparth, N Bordalo, Diana Bom, Ana Todo Cálix, Maria José Ferreira, Tânia Gomes, Joana Vidal, Carmen Mendes, Ana Vasconcelos, Maria João Silva, Pedro Morais Ferraz, José Morête, Ana Pinto, Claúdia Sofia Santos, Natacha Loureiro, Claúdia Chaves Arrobas, Ana Marques, Maria Luís Lozoya, Carlos Lopes, Cristina Cardia, Francisca Loureiro, Carla Chaves Câmara, Raquel Vieira, Inês Silva, Sofia da Silva, Eurico Rodrigues, Natalina Fonseca, João A
author_role	author
author2	Jácome, Cristina Almeida, Rute Pereira, Ana Margarida Alves-Correia, Magna Mendes, Sandra Rodrigues, José Carlos Cidrais Carvalho, Joana Araújo, Luís Costa, Alberto Silva, Armandina Teixeira, Maria Fernanda Ferreira-Magalhães, Manuel Alves, Rodrigo Rodrigues Moreira, Ana Sofia Fernandes, Ricardo M Ferreira, Rosário Pinto, Paula Leiria Neuparth, N Bordalo, Diana Bom, Ana Todo Cálix, Maria José Ferreira, Tânia Gomes, Joana Vidal, Carmen Mendes, Ana Vasconcelos, Maria João Silva, Pedro Morais Ferraz, José Morête, Ana Pinto, Claúdia Sofia Santos, Natacha Loureiro, Claúdia Chaves Arrobas, Ana Marques, Maria Luís Lozoya, Carlos Lopes, Cristina Cardia, Francisca Loureiro, Carla Chaves Câmara, Raquel Vieira, Inês Silva, Sofia da Silva, Eurico Rodrigues, Natalina Fonseca, João A
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	NOVA Medical School\|Faculdade de Ciências Médicas (NMS\|FCM) Centro de Estudos de Doenças Crónicas (CEDOC) Comprehensive Health Research Centre (CHRC) - pólo NMS RUN
dc.contributor.author.fl_str_mv	Amaral, Rita Jácome, Cristina Almeida, Rute Pereira, Ana Margarida Alves-Correia, Magna Mendes, Sandra Rodrigues, José Carlos Cidrais Carvalho, Joana Araújo, Luís Costa, Alberto Silva, Armandina Teixeira, Maria Fernanda Ferreira-Magalhães, Manuel Alves, Rodrigo Rodrigues Moreira, Ana Sofia Fernandes, Ricardo M Ferreira, Rosário Pinto, Paula Leiria Neuparth, N Bordalo, Diana Bom, Ana Todo Cálix, Maria José Ferreira, Tânia Gomes, Joana Vidal, Carmen Mendes, Ana Vasconcelos, Maria João Silva, Pedro Morais Ferraz, José Morête, Ana Pinto, Claúdia Sofia Santos, Natacha Loureiro, Claúdia Chaves Arrobas, Ana Marques, Maria Luís Lozoya, Carlos Lopes, Cristina Cardia, Francisca Loureiro, Carla Chaves Câmara, Raquel Vieira, Inês Silva, Sofia da Silva, Eurico Rodrigues, Natalina Fonseca, João A
dc.subject.por.fl_str_mv	asthma adolescents phenotypes clustering longitudinal studies latent class analysis SDG 3 - Good Health and Well-being
topic	asthma adolescents phenotypes clustering longitudinal studies latent class analysis SDG 3 - Good Health and Well-being
description	Funding: This research was funded by ERDF (European Regional Development Fund) through the operations: POCI-01-0145-36 FEDER-029130 (“mINSPIRE—mHealth to measure and improve adherence to medication in chronic respiratory diseases—generalisation and evaluation of gamification, peer support and advanced image processing technologies”) cofunded by the COMPETE2020 (Programa Operacional Competitividade e Internacionalização), Portugal 2020 and by Portuguese Funds through FCT (Fundação para a Ciência e a Tecnologia).
publishDate	2021
dc.date.none.fl_str_mv	2021-02-03T23:21:12Z 2021-01-24 2021-01-24T00:00:00Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://hdl.handle.net/10362/111251
url	http://hdl.handle.net/10362/111251
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	1660-4601 PURE: 27855565 https://doi.org/10.3390/ijerph18031015
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP
instname_str	Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str	RCAAP
institution	RCAAP
reponame_str	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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Profiling Persistent Asthma Phenotypes in Adolescents

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