Carboxyhemoglobin (COHb)

Detalhes bibliográficos
Autor(a) principal: Carrola, André
Data de Publicação: 2023
Outros Autores: Romão, Carlos C., Vieira, Helena L. A.
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/158007
Resumo: Publisher Copyright: © 2023 by the authors.
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spelling Carboxyhemoglobin (COHb)Unavoidable Bystander or Protective Player?carbon monoxidecarboxyhemoglobincytoprotectionhemoglobinoxidative stressFood SciencePhysiologyBiochemistryMolecular BiologyClinical BiochemistryCell BiologyPublisher Copyright: © 2023 by the authors.Carbon monoxide (CO) is a cytoprotective endogenous gas that is ubiquitously produced by the stress response enzyme heme-oxygenase. Being a gas, CO rapidly diffuses through tissues and binds to hemoglobin (Hb) increasing carboxyhemoglobin (COHb) levels. COHb can be formed in erythrocytes or in plasma from cell-free Hb. Herein, it is discussed as to whether endogenous COHb is an innocuous and inevitable metabolic waste product or not, and it is hypothesized that COHb has a biological role. In the present review, literature data are presented to support this hypothesis based on two main premises: (i) there is no direct correlation between COHb levels and CO toxicity, and (ii) COHb seems to have a direct cytoprotective and antioxidant role in erythrocytes and in hemorrhagic models in vivo. Moreover, CO is also an antioxidant by generating COHb, which protects against the pro-oxidant damaging effects of cell-free Hb. Up to now, COHb has been considered as a sink for both exogenous and endogenous CO generated during CO intoxication or heme metabolism, respectively. Hallmarking COHb as an important molecule with a biological (and eventually beneficial) role is a turning point in CO biology research, namely in CO intoxication and CO cytoprotection.DQ - Departamento de QuímicaUCIBIO - Applied Molecular Biosciences UnitInstituto de Tecnologia Química e Biológica António Xavier (ITQB)RUNCarrola, AndréRomão, Carlos C.Vieira, Helena L. A.2023-09-19T22:15:51Z2023-05-312023-05-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other15application/pdfhttp://hdl.handle.net/10362/158007eng2076-3921PURE: 71916564https://doi.org/10.3390/antiox12061198info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:14:29Zoai:run.unl.pt:10362/158007Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:14:29Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Carboxyhemoglobin (COHb)
Unavoidable Bystander or Protective Player?
title Carboxyhemoglobin (COHb)
spellingShingle Carboxyhemoglobin (COHb)
Carrola, André
carbon monoxide
carboxyhemoglobin
cytoprotection
hemoglobin
oxidative stress
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
title_short Carboxyhemoglobin (COHb)
title_full Carboxyhemoglobin (COHb)
title_fullStr Carboxyhemoglobin (COHb)
title_full_unstemmed Carboxyhemoglobin (COHb)
title_sort Carboxyhemoglobin (COHb)
author Carrola, André
author_facet Carrola, André
Romão, Carlos C.
Vieira, Helena L. A.
author_role author
author2 Romão, Carlos C.
Vieira, Helena L. A.
author2_role author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
UCIBIO - Applied Molecular Biosciences Unit
Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
RUN
dc.contributor.author.fl_str_mv Carrola, André
Romão, Carlos C.
Vieira, Helena L. A.
dc.subject.por.fl_str_mv carbon monoxide
carboxyhemoglobin
cytoprotection
hemoglobin
oxidative stress
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
topic carbon monoxide
carboxyhemoglobin
cytoprotection
hemoglobin
oxidative stress
Food Science
Physiology
Biochemistry
Molecular Biology
Clinical Biochemistry
Cell Biology
description Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-19T22:15:51Z
2023-05-31
2023-05-31T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/158007
url http://hdl.handle.net/10362/158007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2076-3921
PURE: 71916564
https://doi.org/10.3390/antiox12061198
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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