Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.16/2847 |
Resumo: | Nephrotic syndrome may trigger the onset of hypothyroidism, promoting massive urinary protein losses including thyroxine (T4) and triiodothyronine (T3) along with their binding proteins. At an early stage, a clinical and biochemical euthyroid state is expected. However, in patients with prolonged and severe proteinuria, especially with concomitant low thyroid reserve, urinary losses of free and protein-bound thyroid hormones are sufficiently pronounced to induce a subclinical or overt hypothyroidism. Despite its high prevalence in clinical practice, the literature lacks case reports of newly diagnosed clinical hypothyroidism due to NS in adults, making this condition under-recognized. We report a case of a 23-year-old man with previous normal thyroid function who developed overt hypothyroidism due to a severe nephrotic syndrome, requiring supplementation with levothyroxine (LT). After the patient had undergone bilateral nephrectomy, treatment with LT was discontinued and thyroid function normalized. |
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Nephrotic Syndrome as a Cause of Transient Clinical HypothyroidismNephrotic syndrome may trigger the onset of hypothyroidism, promoting massive urinary protein losses including thyroxine (T4) and triiodothyronine (T3) along with their binding proteins. At an early stage, a clinical and biochemical euthyroid state is expected. However, in patients with prolonged and severe proteinuria, especially with concomitant low thyroid reserve, urinary losses of free and protein-bound thyroid hormones are sufficiently pronounced to induce a subclinical or overt hypothyroidism. Despite its high prevalence in clinical practice, the literature lacks case reports of newly diagnosed clinical hypothyroidism due to NS in adults, making this condition under-recognized. We report a case of a 23-year-old man with previous normal thyroid function who developed overt hypothyroidism due to a severe nephrotic syndrome, requiring supplementation with levothyroxine (LT). After the patient had undergone bilateral nephrectomy, treatment with LT was discontinued and thyroid function normalized.Hindawi Pub. CorpRepositório Científico do Centro Hospitalar Universitário de Santo AntónioBenido Silva, VâniaPereira, Maria TeresaLeal Moreira, CarlaSantos Monteiro, SílviaInácio, IsabelCardoso, Helena2023-10-24T11:21:18Z2021-082021-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.16/2847engBenido Silva V, Pereira MT, Moreira CL, Santos Monteiro S, Inácio I, Cardoso MH. Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism. Case Rep Endocrinol. 2021;2021:5523929. doi:10.1155/2021/55239292090-651X10.1155/2021/5523929info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-26T05:19:19Zoai:repositorio.chporto.pt:10400.16/2847Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:39:39.190498Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism |
title |
Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism |
spellingShingle |
Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism Benido Silva, Vânia |
title_short |
Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism |
title_full |
Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism |
title_fullStr |
Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism |
title_full_unstemmed |
Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism |
title_sort |
Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism |
author |
Benido Silva, Vânia |
author_facet |
Benido Silva, Vânia Pereira, Maria Teresa Leal Moreira, Carla Santos Monteiro, Sílvia Inácio, Isabel Cardoso, Helena |
author_role |
author |
author2 |
Pereira, Maria Teresa Leal Moreira, Carla Santos Monteiro, Sílvia Inácio, Isabel Cardoso, Helena |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Centro Hospitalar Universitário de Santo António |
dc.contributor.author.fl_str_mv |
Benido Silva, Vânia Pereira, Maria Teresa Leal Moreira, Carla Santos Monteiro, Sílvia Inácio, Isabel Cardoso, Helena |
description |
Nephrotic syndrome may trigger the onset of hypothyroidism, promoting massive urinary protein losses including thyroxine (T4) and triiodothyronine (T3) along with their binding proteins. At an early stage, a clinical and biochemical euthyroid state is expected. However, in patients with prolonged and severe proteinuria, especially with concomitant low thyroid reserve, urinary losses of free and protein-bound thyroid hormones are sufficiently pronounced to induce a subclinical or overt hypothyroidism. Despite its high prevalence in clinical practice, the literature lacks case reports of newly diagnosed clinical hypothyroidism due to NS in adults, making this condition under-recognized. We report a case of a 23-year-old man with previous normal thyroid function who developed overt hypothyroidism due to a severe nephrotic syndrome, requiring supplementation with levothyroxine (LT). After the patient had undergone bilateral nephrectomy, treatment with LT was discontinued and thyroid function normalized. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08 2021-08-01T00:00:00Z 2023-10-24T11:21:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.16/2847 |
url |
http://hdl.handle.net/10400.16/2847 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Benido Silva V, Pereira MT, Moreira CL, Santos Monteiro S, Inácio I, Cardoso MH. Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism. Case Rep Endocrinol. 2021;2021:5523929. doi:10.1155/2021/5523929 2090-651X 10.1155/2021/5523929 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Pub. Corp |
publisher.none.fl_str_mv |
Hindawi Pub. Corp |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133657993052160 |