New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/26597 |
Resumo: | Three new hydrophilic 3-hydroxy-4-pyridinone chelators containing ether-derived substituents were prepared by a more sustainable synthetic protocol that involves the use of microwave heating and commercially available amines, allowing the successful production of highly water soluble chelators with improved reaction yields and reaction times. Compared with parent 3-hydroxy-4-pyridinone ligands, the new compounds were obtained faster and in higher amounts, facilitating the scale up of the synthesis, which is crucial to produce these ligands and their respective iron(III) complexes for many biological, analytical and agricultural applications. Ligands were fully characterized by 1H and 13C Nuclear Magnetic Resonance, High Resolution Mass Spectrometry and Single Crystal X-Ray Diffraction and their performance in the analytical determination of iron(III) in water samples was evaluated by sequential injection methods. The results obtained are scientifically relevant, pointing out the potential of the new and straightforwardly synthesized ligands as analytical reagents for determination of iron(III). |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters3-hydroxy-4-pyridinoneIron chelatorWater solubilityMicrowave assisted synthesisX-ray diffractionSequential injectionThree new hydrophilic 3-hydroxy-4-pyridinone chelators containing ether-derived substituents were prepared by a more sustainable synthetic protocol that involves the use of microwave heating and commercially available amines, allowing the successful production of highly water soluble chelators with improved reaction yields and reaction times. Compared with parent 3-hydroxy-4-pyridinone ligands, the new compounds were obtained faster and in higher amounts, facilitating the scale up of the synthesis, which is crucial to produce these ligands and their respective iron(III) complexes for many biological, analytical and agricultural applications. Ligands were fully characterized by 1H and 13C Nuclear Magnetic Resonance, High Resolution Mass Spectrometry and Single Crystal X-Ray Diffraction and their performance in the analytical determination of iron(III) in water samples was evaluated by sequential injection methods. The results obtained are scientifically relevant, pointing out the potential of the new and straightforwardly synthesized ligands as analytical reagents for determination of iron(III).ElsevierVeritati - Repositório Institucional da Universidade Católica PortuguesaMoniz, TâniaCunha-Silva, LuísMesquita, Raquel B.R.Miranda, Joana L.A.Silva, André M.N.Silva, Ana M.G.Rangel, António O.S.S.Castro, Baltazar deRangel, Maria2021-03-01T01:30:09Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/26597engMoniz, T., Cunha-Silva, L., Mesquita, R. B., Miranda, J. L., Silva, A. M., Silva, A. M., ... & Rangel, M. (2019). New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters. Polyhedron, 160, 145-1560277-538710.1016/j.poly.2018.12.00585059627781000459518800020info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-10T01:39:20Zoai:repositorio.ucp.pt:10400.14/26597Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:21:14.073057Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters |
title |
New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters |
spellingShingle |
New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters Moniz, Tânia 3-hydroxy-4-pyridinone Iron chelator Water solubility Microwave assisted synthesis X-ray diffraction Sequential injection |
title_short |
New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters |
title_full |
New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters |
title_fullStr |
New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters |
title_full_unstemmed |
New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters |
title_sort |
New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters |
author |
Moniz, Tânia |
author_facet |
Moniz, Tânia Cunha-Silva, Luís Mesquita, Raquel B.R. Miranda, Joana L.A. Silva, André M.N. Silva, Ana M.G. Rangel, António O.S.S. Castro, Baltazar de Rangel, Maria |
author_role |
author |
author2 |
Cunha-Silva, Luís Mesquita, Raquel B.R. Miranda, Joana L.A. Silva, André M.N. Silva, Ana M.G. Rangel, António O.S.S. Castro, Baltazar de Rangel, Maria |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Moniz, Tânia Cunha-Silva, Luís Mesquita, Raquel B.R. Miranda, Joana L.A. Silva, André M.N. Silva, Ana M.G. Rangel, António O.S.S. Castro, Baltazar de Rangel, Maria |
dc.subject.por.fl_str_mv |
3-hydroxy-4-pyridinone Iron chelator Water solubility Microwave assisted synthesis X-ray diffraction Sequential injection |
topic |
3-hydroxy-4-pyridinone Iron chelator Water solubility Microwave assisted synthesis X-ray diffraction Sequential injection |
description |
Three new hydrophilic 3-hydroxy-4-pyridinone chelators containing ether-derived substituents were prepared by a more sustainable synthetic protocol that involves the use of microwave heating and commercially available amines, allowing the successful production of highly water soluble chelators with improved reaction yields and reaction times. Compared with parent 3-hydroxy-4-pyridinone ligands, the new compounds were obtained faster and in higher amounts, facilitating the scale up of the synthesis, which is crucial to produce these ligands and their respective iron(III) complexes for many biological, analytical and agricultural applications. Ligands were fully characterized by 1H and 13C Nuclear Magnetic Resonance, High Resolution Mass Spectrometry and Single Crystal X-Ray Diffraction and their performance in the analytical determination of iron(III) in water samples was evaluated by sequential injection methods. The results obtained are scientifically relevant, pointing out the potential of the new and straightforwardly synthesized ligands as analytical reagents for determination of iron(III). |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2021-03-01T01:30:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/26597 |
url |
http://hdl.handle.net/10400.14/26597 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Moniz, T., Cunha-Silva, L., Mesquita, R. B., Miranda, J. L., Silva, A. M., Silva, A. M., ... & Rangel, M. (2019). New hydrophilic 3-hydroxy-4-pyridinone chelators with ether-derived substituents: synthesis and evaluation of analytical performance in the determination of iron in waters. Polyhedron, 160, 145-156 0277-5387 10.1016/j.poly.2018.12.005 85059627781 000459518800020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799131912764129280 |